Could a vibrating wristband quiet your shaky hands?
NCT ID NCT07078422
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a wristband that delivers gentle, personalized vibrations to the wrist to help reduce hand tremors in people with essential tremor or Parkinson's disease. About 80 participants will use the device at home over several weeks. The goal is to see if the device is easy to use and if it can improve daily activities like eating or writing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Encora Pulse wristband (mechanical vibration device)
- What this could lead to
- If successful, this could offer a non-invasive, drug-free option to help people with essential tremor or Parkinson's disease control hand tremors during daily activities.
- What could go wrong
- This is an early-stage, small study focused on usability and design, not yet proven to work. The device may not reduce tremors for everyone, and long-term benefits are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria - Alpha and Beta Phase B1 * Age 18 years or older, able to comply with all study procedures and capable of providing informed consent. * Mentally competent to understand and able to perform written, informed consent to participate in the study * A diagnosis of either ET or PD as determined by clinical history * Moderate to severe upper limb tremor Exclusion Criteria - Alpha and Beta Phase B1 * Pregnant women * Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site * History of psoriasis, eczema or atopic dermatitis at the stimulation site * History of peripheral neuropathy in the upper limbs, including carpal tunnel syndrome and diabetic neuropathy * Participant unable to communicate with sponsor/investigator and staff * Any other medical conditions or physical or mental impairments that in the sponsor/investigator's opinion would render the subject unsuitable as a candidate for the study. Inclusion Criteria - Beta Phase B2 * Age 18 years or older, able to comply with all study procedures and capable of providing informed consent * Mentally competent to understand and able to perform written, informed consent to participate in the study * For ET subjects, a diagnosis of essential tremor defined as definite or probable ET based on TRIG criteria * For PD subjects, a diagnosis of Parkinson's disease by a Movement Disorder Specialist * For ET subjects, at least one hand exhibiting tremor \> 2 as assessed by the Essential Tremor Rating Assessment Scale (TETRAS) finger to nose task, duck wing task, OR Archimedes Spiral completed during the Screening visit * For PD subjects, a score \> 2 on at least one of MDS-UPDRS items 3.15, 3.16 or 3.17 At the Screening Visit, a score of \> 3 on one of the following subject-assessed items of the Bain \& Findley Activities of Daily Living Scale (BF-ADL): Use a spoon to drink soup, Hold a cup of tea, Do up buttons, Do up a zipper, Write a letter * Stable medications for at least 30 days prior to enrollment and the ability to maintain tremor medications throughout the duration of study participation * For PD subjects, able to participate in visits in a practically defined OFF state (withdrawal from all tremor medication for 12 hours prior to study visits) * A wrist circumference of 6.0 - 8.1 inches Exclusion Criteria - Beta Phase B2 * Pregnant women * Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site * History of psoriasis, eczema or atopic dermatitis at the stimulation site * History of peripheral neuropathy in the upper limbs, including carpal tunnel syndrome and -diabetic neuropathy * Participant unable to communicate with sponsor/investigator and staff * Any other medical conditions or physical or mental impairments that in the sponsor/investigator's opinion would render the subject unsuitable as a candidate for the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Encora Therapeutics
RECRUITINGCambridge, Massachusetts, 02142, United States
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