Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can new brain stimulation patterns quiet stubborn tremors?

NCT ID NCT03811405

Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study tests whether changing the way deep brain stimulation is delivered can improve tremor control in people with essential tremor who don't get enough relief from their current settings. Researchers will use computer models and brain scans to see how the new stimulation patterns affect nerve fibers, and they will measure tremor severity with a standard rating scale. The goal is to find a way to help the roughly 20% of patients whose tremors worsen over time despite treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deep brain stimulation with active biphasic pulse settings
What this could lead to
If successful, this could offer a way to improve tremor control for essential tremor patients who don't respond well to standard deep brain stimulation.
What could go wrong
This is a small early-stage study, so results may not apply to everyone. The new stimulation patterns might not work better than current settings or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Apr 2021

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Existing unilateral or bilateral VIN DBS for ET, non-demented (MMSE\>24), and must have a documented suboptimal tremor suppression on two successive visits (compared to the baseline post-operative improvement at 6 months following ET DBS surgery). For bilateral cases, the most affected tremor side will be studied. Exclusion Criteria: * No diagnosis of Essential Tremor

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Dystonia are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Dystonia dystonic disorder essential tremor Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dystonia Essential tremor Parkinson disease

Contacts and locations

Locations

  • McKnight Brain Institute--Fixel Center for Neurological Diseases

    Gainesville, Florida, 32611, United States

  • UF Health at the University of Florida

    Gainesville, Florida, 32610, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.