Parkinson's research gets a boost: 4,500 volunteers help map disease progression

NCT ID NCT04477785

Recruiting now Knowledge-focused Sponsor: Michael J. Fox Foundation for Parkinson's Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This observational study, led by the Michael J. Fox Foundation, aims to understand how Parkinson's disease progresses over time. It will follow 4,500 people, including those with Parkinson's, those at risk, and healthy volunteers, collecting clinical, imaging, and genetic data. The goal is to identify markers of progression that can be used in future trials to test treatments that might slow or stop the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify reliable markers of Parkinson's progression, enabling more effective clinical trials for treatments that slow the disease.
What could go wrong: This is an observational study, not a treatment trial, so no direct benefit to participants. Results depend on long-term follow-up and may not translate into immediate therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Anosmia neurodegenerative disease Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

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Locations

Banner Research Institute
RECRUITING

Sun City, Arizona, 85351, United States
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Beth Israel Medical Center
RECRUITING

New York, New York, 10003, United States
Boston University
RECRUITING

Boston, Massachusetts, 02118, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Lou Ruvo Center for Brain Health
RECRUITING

Las Vegas, Nevada, 89106, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30329, United States
Foundation for Biomedical Research of the Academy of Athens
RECRUITING

Athens, Athens, 11523, Greece
Hospital Clinic de Barcelona
RECRUITING

Barcelona, Barcelona, 08036, Spain
Hospital Donostia
RECRUITING

Donostia / San Sebastian, San Sebastian, 20014, Spain
Imperial College London
RECRUITING

London, W12 0NN, United Kingdom
Innsbruck Medical University
RECRUITING

Innsbruck, 6020, Austria
Institute For Neurodegenerative Disorders
RECRUITING

New Haven, Connecticut, 06510, United States
John Radcliffe Hospital Oxford and Oxford University
RECRUITING

Oxford, Oxford, OX3 9DU, United Kingdom
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Keck School of Medicine of USC
RECRUITING

Los Angeles, California, 90033, United States
Lagos College of Medicine, University of Lagos
RECRUITING

Lagos, Lagos, 121010, Nigeria
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02446, United States
Mayo Foundation for Medical Education and Research
RECRUITING

Scottsdale, Arizona, 85259, United States
McGill University
RECRUITING

Montreal, Quebec, H3A2B4, Canada
NYU Langone Health
RECRUITING

New York, New York, 10017, United States
Newcastle University
RECRUITING

Newcastle upon Tyne, Tyne and Wear, NE45PL, United Kingdom
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Oregon Health &Science University
RECRUITING

Portland, Oregon, 97239, United States
Paracelsus-Elena Klinik
RECRUITING

Kassel, 34128, Germany
Parkinson Research Clinic
RECRUITING

Luxembourg, L-1257, Luxembourg
Parkinson's Disease& Movement Disorder Center of Boca Raton
RECRUITING

Boca Raton, Florida, 33486, United States
Philipps-University of Marburg
RECRUITING

Hessen, 35043, Germany
Queen Mary University of London
RECRUITING

London, Britain, EC1M 6BQ, United Kingdom
Radboud University
RECRUITING

Nijmegen, Gelderland, 6525 GC, Netherlands

Contact Email: •••••@•••••
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, Tel Aviv, 64239, Israel
The Ottawa Hospital - Civic Campus
RECRUITING

Ottawa, Ontario, K1Y 4E9, Canada
Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada
Univ of Washington and VA Puget Sound Health Care System
RECRUITING

Seattle, Washington, 98104, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California San Diego
RECRUITING

La Jolla, California, 92093-0948, United States

Contact Email: •••••@•••••
University of California, San Francisco
RECRUITING

San Francisco, California, 94115, United States
University of Cincinnati/Cincinnati Children's Hospital
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Florida
RECRUITING

Gainesville, Florida, 32608, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Luebeck
RECRUITING

Lübeck, 23562, Germany
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester
RECRUITING

Rochester, New York, 14620, United States
University of Salerno
RECRUITING

Salerno, Salerno, 84131, Italy
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
University of Tuebingen
RECRUITING

Tübingen, 72076, Germany

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