Could a nasal spray help Parkinson's? new trial tests insulin and glutathione combo

NCT ID NCT05266417

Recruiting now Disease control Sponsor: Gateway Institute for Brain Research Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This phase 2 trial is testing whether a nasal spray containing insulin and glutathione can safely improve symptoms in people with Parkinson's disease. About 56 participants will receive either the active spray or a placebo, added to their usual medications. The study focuses on changes in thinking (verbal fluency) and movement (timed walking, UPDRS scores).

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intranasal insulin and glutathione
What this could lead to: If it works, this could point toward a new add-on treatment to help manage Parkinson's symptoms, potentially improving thinking and movement.
What could go wrong: This is a small, early-phase trial (56 people) testing safety and effectiveness. The treatment may not work better than placebo, and results may not apply to all Parkinson's patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

Charter Research
RECRUITING

The Villages, Florida, 32162, United States
Institute for Neuroimmune Medicine
RECRUITING

Davie, Florida, 33314, United States
Las Mercedes Medical Research
RECRUITING

Hialeah, Florida, 33012, United States
NextGen Research Group
RECRUITING

Miami, Florida, 33165, United States

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