PARKINSON DISEASE

This early-stage trial tests whether injecting lab-grown dopamine-producing cells into the brain is safe and can improve motor function in 12 people with advanced Parkinson's disease. Participants must be 55-75 years old, have had Parkinson's for over 5 years, and experience sign…

This study tests a new way to use deep brain stimulation (DBS) in people with early-stage Parkinson's disease. The goal is to see if targeting a specific brain area can safely control symptoms and possibly slow down the disease. About 40 participants will receive DBS and be monit…

This study tests whether lecanemab, an FDA-approved Alzheimer's drug, can clear amyloid plaques in the brains of people with Parkinson's disease who also have early Alzheimer's changes. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecan…

This study tests an experimental oral drug, GT-02287, in 111 people with early Parkinson's disease. Participants will receive one of two doses or a placebo for 48 weeks. The goal is to see if the drug can improve daily function and movement, and to check its safety and effects on…

This study tests a single injection of AB-1005 gene therapy directly into the brain for Japanese adults with moderate Parkinson's disease. The goal is to see if it is safe and can improve motor function and reduce daily symptoms. Eight participants will be followed for 18 months …

This study tests whether a smartphone app can help doctors personalize Parkinson's medication to prevent impulse control disorders—like compulsive gambling or shopping—that affect up to half of patients. About 528 adults with early Parkinson's will be randomly assigned to standar…

This study tests a new, high-dose brain stimulation method to help people with Parkinson's disease who have trouble walking, including freezing and falls. Researchers will use a non-invasive technique called repetitive transcranial magnetic stimulation (rTMS) on 20 participants. …

This study tests if simple eye exercises can improve walking, balance, and reduce fear of falling in people with Parkinson's disease. About 34 adults with mild to moderate Parkinson's will do supervised eye-movement training. The goal is to see if this easy, drug-free approach ca…

This study looks at treatments for overactive bladder in people with Parkinson's disease. It will test if starting with behavioral therapy or medication works best, and if combining both helps those who don't improve with one treatment alone. About 146 adults with Parkinson's and…

This study tests whether combining virtual reality games with a type of stretching called proprioceptive neuromuscular facilitation can improve arm movement and reduce tremors in people with Parkinson's disease. About 28 adults aged 50-80 with mild to moderate Parkinson's will pa…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve motor function in people with Parkinson's disease. Thirty adults with moderate-stage Parkinson's will receive repeated sessions over a week. The goal is to see if this safe, portable treat…

This study tests whether a virtual reality (VR) rehab program done at home can help people with stroke or Parkinson's disease improve their movement and thinking skills. Sixty adults will either use a VR headset for guided exercises or receive standard rehab. The goal is to see i…

This early-stage study will test a new drug called Lu AF28996 in 10 Chinese adults with Parkinson's disease. The main goal is to check if the drug is safe and how the body processes it. This is a first step to see if the drug might help control Parkinson's symptoms in the future.

This study tests whether virtual reality (VR) physiotherapy can improve balance, lower fall risk, and boost heart and lung fitness in people with Parkinson's disease. Fifty participants aged 55 to 75 with mild to moderate Parkinson's will be randomly assigned to either VR-based o…

This study tests whether adding game-like features (points, challenges) to a step-tracking program helps veterans with Parkinson's disease become more active. About 110 veterans will either use the gamified program or a standard activity tracker. The goal is to see if more moveme…

This study tests whether a 10-week balance-focused exercise program can improve how the soleus muscle activates when starting to walk in people with Parkinson's disease. Researchers will enroll 80 participants in Kuwait who can walk independently. The goal is to see if these exer…

This study tests an experimental drug called FHL-301 in 32 adults with early-stage Parkinson's disease. Half will get the drug and half a placebo, and researchers will measure changes in movement symptoms over about a year. The goal is to see if the drug is safe and can help cont…

This early study is testing a new virtual reality (VR) game system designed to help with Parkinson's disease rehabilitation. Researchers want to see if healthy adults aged 50 to 70 find the system safe, easy to use, and acceptable. Participants will use either a head-mounted disp…

This study tests a robot-guided exercise program for people with mild to moderate Parkinson's disease. Participants will exercise three times a week for three weeks, either in person or remotely. The goal is to see if the program is safe, doable, and helps improve mobility and st…

This pilot study tests whether special shoes that vibrate can safely help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Researchers will enroll 20 participants to see if the vibration feedback is tolerable a…

This study tests whether a special 40 Hz flickering light can improve sleep in people with Parkinson's disease who have trouble sleeping. Thirty participants will use either the flickering light or a regular light for 30 minutes each night for a week. The goal is to see if the li…

This study tests a new, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) to see if it can safely improve movement problems in people with Parkinson's disease. The trial will enroll 20 adults with stable Parkinson's who will rece…

This study will test if a gentle form of ultrasound, called low-intensity focused ultrasound (LIFU), can safely change brain activity in people with Parkinson's disease. Fifteen adults aged 45 to 80 will receive the treatment, and researchers will watch for side effects and measu…

This study compares two exercise programs—vestibular rehabilitation (balance exercises) and dual-task training (combining thinking and movement)—to see which better improves balance, thinking, and movement in people with Parkinson's disease. 45 participants aged 40-75 with mild t…

This study looks at how people with Parkinson's disease imagine movements, sense their body, and fear moving, and how these factors relate to their symptoms and physical frailty. Researchers will observe 100 adults aged 40-85 with mild to moderate Parkinson's. The goal is to bett…

This study brings together 30 Italian experts to agree on the best ways to use deep brain stimulation (DBS) for Parkinson's disease. DBS uses a device to send electrical pulses to specific brain areas, helping control symptoms like tremors and stiffness. The goal is to create cle…

This study checks if a Turkish version of the Cognitive Self-Efficacy Questionnaire is a reliable and accurate tool for people with Parkinson's disease. About 100 adults aged 40-85 with Parkinson's and normal thinking skills will fill out the questionnaire twice. The goal is to h…

This pilot study will test a flexible, home-based care pathway for 100 people newly diagnosed with Parkinson's disease and their caregivers. The program includes a booklet and website to provide information and support right after diagnosis. The goal is to see if this approach he…

This study looks at how sleep quality relates to thinking abilities and disease severity in 75 people with Parkinson's disease. Participants will complete one session of tests measuring sleep, memory, attention, and motor symptoms. The goal is to better understand these connectio…

This study will test whether an artificial intelligence system can accurately rate Parkinson's disease motor symptoms from smartphone video recordings. Researchers will enroll 500 adults with Parkinson's to perform standard movement tasks while being filmed. The AI's ratings will…