PARKINSON DISEASE

This study tests a single injection of AB-1005 gene therapy directly into the brain for Japanese adults with moderate Parkinson's disease. The goal is to see if it is safe and can improve daily movement. Eight participants will be followed for 18 months.

This pilot study will test whether a virtual reality (VR) rehab program done at home can help people recover movement and thinking skills after a stroke or with Parkinson's disease. Sixty participants will either use a VR headset for daily exercises or receive standard rehab. The…

This study tests whether an 8-week plant-based diet, rich in fiber and low in processed foods, can improve gut bacteria and reduce inflammation in people with Parkinson's disease. Researchers will track 75 participants to see if the diet leads to healthier gut microbes and better…

This study tests whether lecanemab, a drug that clears amyloid plaques in Alzheimer's disease, can also help people with Parkinson's disease who have amyloid buildup in their brains. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecanema…

This early-stage trial will test the safety and tolerability of a new oral drug called Lu AF28996 in 10 Chinese adults with Parkinson's disease. Participants will take the drug and be monitored for side effects and how the body processes it. The study is not yet recruiting and do…

This study tests a new way to use deep brain stimulation (DBS) in people with early-stage Parkinson's disease. The goal is to see if targeting a specific brain area can safely slow or stop worsening of motor symptoms. About 40 participants will receive DBS plus standard medicatio…

This early-stage trial tests a single injection of lab-grown dopamine-producing cells into the brains of 12 people with advanced Parkinson's disease. The goal is to see if the procedure is safe and if it can improve motor function and quality of life. Participants must be between…

This study tests an oral drug called GT-02287 in 111 people with early Parkinson's disease. Participants will receive either a low dose, high dose, or placebo for 48 weeks. The goal is to see if the drug improves daily movement and motor symptoms, and to check its safety and effe…

This phase 2 trial is testing whether FHL-301 (gemfibrozil, a drug usually used for cholesterol) can help control motor symptoms in people with early-stage Parkinson's disease. Thirty-two adults aged 40 to 75 will receive either the drug or a placebo for up to 48 weeks. The main …

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study will test a new intelligent diagnostic system for orthostatic hypotension (a sudden drop in blood pressure when standing up). The system continuously monitors blood pressure, brain blood flow, and heart signals to classify the condition more precisely. Researchers plan…

This study tests whether a smartphone app, called ICD-Shield, can help doctors adjust Parkinson's medications to prevent impulse control disorders (like compulsive gambling or shopping). About 528 people with early-stage Parkinson's will be randomly assigned to use the app or rec…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study will test whether a special exercise program called LSVT BIG, done via video calls at home, works as well as the same program done in a clinic. Forty people with mild-to-moderate Parkinson's disease will be randomly assigned to either remote or in-person therapy for 4 …

This study will test a comfortable, soft elbow brace that helps bend and straighten the arm, along with a vibrating forearm bracelet that gives touch cues. About 45 people with stroke or Parkinson's disease will try these devices during arm exercises. The goal is to see if the de…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This pilot study tests whether a special shoe that vibrates can safely help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Twenty participants will wear the smartshoes and researchers will measure how well th…

This study tests whether immersive virtual reality (VR) therapy can improve balance, reduce fall risk, and boost cardiorespiratory fitness in people with Parkinson's disease. Fifty participants aged 55–75 with mild to moderate Parkinson's will be randomly assigned to either VR-ba…

This study will test a special moving platform combined with virtual reality to help people with neurological disorders like Parkinson's disease, stroke, ALS, or mild cognitive impairment improve their balance and movement. The platform moves in three directions and adapts exerci…

This study tests two treatments—mirabegron (a drug) and exercise-based behavioral therapy—for overactive bladder in people with Parkinson's disease. Researchers want to see if combining treatments helps those who don't respond to one alone. The trial will involve 146 participants…

This early study will test whether low-intensity focused ultrasound (LIFU) can safely stimulate a brain region in people with Parkinson's disease. Fifteen participants will receive a single session of LIFU. The main goal is to check for side effects, with a secondary look at whet…

This study tests whether repeated sessions of a gentle brain stimulation technique called tDCS can improve motor function in people with Parkinson's disease. Thirty adults with moderate-stage Parkinson's will receive stimulation over several days. The goal is to see if this safe,…

This study will test whether virtual reality therapy combined with proprioceptive neuromuscular facilitation (a type of hands-on exercise) can improve arm movement, reduce tremors, and enhance body awareness in people with Parkinson's disease. Twenty-eight participants will recei…

This study is testing whether virtual reality (VR) and augmented reality (AR) games can be a safe and easy-to-use tool for rehab in people with Parkinson's disease. Thirty healthy volunteers aged 50 to 70 will try the game system for four sessions over two weeks. Researchers will…

This study tests a new, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) to see if it can improve movement problems in people with Parkinson's disease. Twenty participants will be randomly assigned to receive either real TIS or …

This study tests a new type of cycling called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking ability, fatigue, and quality of life better than standard cycling. Sixty adults with MS who can walk independently …

This study tests whether a special 40 Hz flickering light, used for 30 minutes each night for a week, can improve insomnia in people with Parkinson's disease. Thirty participants will be randomly assigned to receive either the 40 Hz light or a control light. The main goal is to s…

This study tests whether a gamification program—using game-like rewards and challenges—can help veterans with Parkinson's disease become more physically active. About 110 veterans will either use the gamification program or continue their usual routine. The goal is to see if incr…

This study tests two types of exercise in people with Parkinson's disease: one focuses on balance exercises (vestibular rehab), the other combines thinking tasks with movement (dual-task training). Forty-five participants will do supervised exercises twice a week for eight weeks.…

This study tests whether a 10-week balance-focused exercise program can improve how the calf muscle activates when starting to walk in people with Parkinson's disease. Researchers in Kuwait will enroll 80 participants who can walk independently. The goal is to see if these exerci…

This study tests a new, high-dose form of non-invasive brain stimulation (called accelerated theta burst stimulation) to see if it can improve walking problems, like freezing, in people with Parkinson's disease. The study will enroll 20 adults with early-stage Parkinson's who hav…

This study looks at how a brain region called the subthalamic nucleus (STN) is involved in sleep and wakefulness in people with Parkinson's disease. Researchers will record brain activity during sleep using special electrodes already implanted for deep brain stimulation. The goal…

This study looks at how Parkinson's disease affects arm and hand skills, trunk control, and body awareness. Researchers will compare 118 people with Parkinson's (ages 50-80) to healthy adults using tests like pegboard, grip strength, and reaction time. The goal is to understand t…

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This pilot study will test a flexible, home-based care pathway for 100 people newly diagnosed with Parkinson's disease and their caregivers. The program includes questionnaires and educational tools to help patients and families better understand the disease and manage their care…

This study tests a driving simulator designed to help people with neurological conditions like stroke, Parkinson's, ALS, or mild cognitive impairment improve their motor and thinking skills. About 60 participants (including healthy volunteers) will use the simulator to see if it …

This study will check if a Turkish version of a questionnaire about thinking confidence (cognitive self-efficacy) works well for people with Parkinson's disease. Around 100 participants will fill out the questionnaire, and researchers will see if it is reliable and accurate. This…

This study looks at how people with Parkinson's disease imagine movements, sense their own bodies, and fear physical activity, and how these factors relate to their symptoms and frailty. Researchers will assess 100 participants using questionnaires and physical tests. The goal is…

This study will test an artificial intelligence system that uses smartphone video to rate motor symptoms in people with Parkinson's disease. Researchers aim to make assessments more objective and less time-consuming than current methods. The trial will enroll 500 participants in …

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study brings together 30 Italian experts to agree on the best ways to use deep brain stimulation (DBS) for Parkinson's disease. DBS uses electrical pulses to improve movement problems, but practices vary widely. Through a series of surveys, the experts will develop clear gui…