PARKINSON DISEASE

This early-stage study tests whether injecting lab-grown dopamine-producing brain cells is safe and might help control Parkinson's disease. Doctors will transplant these cells into the brains of 12 patients with advanced Parkinson's to see if they can restore some lost function. …

This study is testing whether a specific type of deep brain stimulation (DBS) can safely slow down the worsening of movement symptoms in people with early-stage Parkinson's disease. Researchers will implant a 'brain pacemaker' in 40 participants and compare two different stimulat…

This study is testing the safety and drug levels of HBI-002, a daily oral liquid containing a low dose of carbon monoxide (CO), in people with Parkinson's disease. Over 14 days, 36 participants will take either the drug or a placebo. The main goal is to see if the treatment is sa…

This study is testing whether adding the anti-inflammatory drug etoricoxib to standard Parkinson's treatment helps control symptoms better. Researchers will enroll 60 adults with Parkinson's who are already on conventional therapy. The goal is to see if reducing brain inflammatio…

This study is testing whether a new oral medication, GT-02287, can slow the progression of Parkinson's disease. It will involve about 111 people with early-stage Parkinson's, who will take either the drug or a placebo for 48 weeks. Researchers will measure changes in movement, da…

This study is testing an investigational drug called FHL-301 in adults with early-stage Parkinson's disease. It aims to see if the drug is safe, well-tolerated, and can help control the movement symptoms of the disease. Participants will be randomly assigned to receive either FHL…

This early study is testing whether low-intensity focused ultrasound is safe and tolerable for people with Parkinson's disease. It will enroll 15 participants to see if this non-invasive sound wave treatment can help regulate brain activity. The main goal is to check for any side…

This study aims to develop and test an artificial intelligence (AI) system that can assess the severity of Parkinson's disease motor symptoms. Researchers will record videos of 500 participants with Parkinson's performing standard movement tasks using a smartphone camera. The AI'…

This study is testing a new virtual reality (VR) training method to help people with Parkinson's disease move faster and more easily. Participants will watch 3D videos of themselves performing movements while wearing a VR headset, with the goal of improving their own movement spe…

This study is testing whether a special 40Hz flickering light can help improve sleep in people with Parkinson's disease. About 30 participants will use the light for 30 minutes at bedtime for 7 nights. Researchers will compare the flickering light to a regular light to see if it …

This study tests whether a new, intensive form of non-invasive brain stimulation can help improve walking difficulties, especially 'freezing of gait,' in people with Parkinson's disease. Researchers will use magnetic pulses targeted at specific brain networks to see if this appro…

This study is testing whether repeatedly applying gentle, non-invasive electrical stimulation to both sides of the brain can improve movement problems in people with Parkinson's disease. It will involve 30 participants with moderate Parkinson's to see if the treatment's benefits …

This study aims to see if a 10-week exercise program focused on balance can help people with Parkinson's disease start walking more easily. Researchers will measure how a specific leg muscle works during the first step. The trial will involve 80 participants in Kuwait who will be…

This study is testing whether using immersive virtual reality (VR) during physiotherapy is better than standard physiotherapy for improving balance, reducing the risk of falls, and increasing fitness in people with Parkinson's disease. Researchers will randomly assign 50 particip…

This study is testing whether a new, non-invasive brain stimulation technique can safely improve movement problems in people with Parkinson's disease. Twenty participants will be randomly assigned to receive either the real stimulation or a sham (fake) treatment. The goal is to s…

This study is testing if a phone-based game that rewards people for walking can help veterans with Parkinson's disease get more physical activity. Researchers want to see if increasing daily steps can improve movement problems like slowness and tremor, as well as other symptoms l…

This study is testing whether three new patterns of deep brain stimulation (DBS) are safe and comfortable for people with Parkinson's disease to use at home. The study involves 60 people who already have a stable DBS implant. Each participant will try one of the new stimulation p…

This study is testing whether combining two approaches works better for Parkinson's patients with overactive bladder symptoms when one treatment alone isn't enough. Researchers will give 146 veterans with Parkinson's either pelvic floor exercises or medication first, then add the…

This study is testing a robot-guided exercise system called ZEST-E to help people with Parkinson's disease improve their strength and range of motion. Participants will do robot-guided exercises three times a week for three weeks, with some sessions monitored in person and others…

This study aims to see which of two exercise programs works better for people with Parkinson's disease. One program focuses on balance training, while the other combines physical movement with mental tasks. About 45 participants will be assigned to one of the programs or a contro…

This study aims to see if a small, portable pump that delivers a Parkinson's medication under the skin can improve comfort for patients in the final stages of the disease. It will test if the pump reduces severe muscle stiffness, pain, and agitation, and makes care easier for fam…

This study aims to develop and test virtual reality game systems to help with Parkinson's disease rehabilitation. Researchers will have 30 healthy volunteers try two different VR setups to see if they are safe, easy to use, and acceptable as a potential therapy. The goal is to cr…

This study aims to see if virtual reality games or a specific hands-on physical therapy technique works better to improve arm movement, reduce tremors, and enhance coordination in people with Parkinson's disease. It will involve 28 participants who will try one of the two therapy…

This study aims to create national guidelines for using deep brain stimulation (DBS) to treat advanced Parkinson's disease. Italian medical experts will work together to agree on best practices for patient selection, surgical approaches, and long-term care. The goal is to standar…

This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa treatment, compared with a placebo. The study will la…