PARKINSON DISEASE

This study tests whether a low dose of lithium (20 mg/day) can slow disease-related changes in the brain and blood of people with early-stage Parkinson's disease. Twenty participants will receive either lithium or a placebo for a period, and researchers will use MRI scans and blo…

This trial will test whether deep brain stimulation (DBS) surgery improves movement, balance, and daily function in 40 people with Parkinson's disease. Participants will have their walking speed, balance, muscle strength, and activity levels measured before and after surgery. The…

This study tests an experimental drug called BIIB122 in 50 people who have a specific genetic form of Parkinson's disease (LRRK2-PD). The main goal is to check the drug's safety and how it affects certain markers in the blood and urine over 12 weeks. Participants are randomly ass…

This early-stage trial tests whether implanting a person's own lab-grown dopamine cells into their brain is safe for Parkinson disease. Nine participants aged 40-75 with Parkinson for at least 4 years will receive the injection. The goal is to see if the cells can replace lost do…

This study tests a procedure called focused ultrasound (Exablate) that uses sound waves to target a small area in the brain involved in Parkinson's disease. It involves 67 people with early-stage Parkinson's who will either receive the ultrasound treatment or continue with standa…

This early-phase study tests a new type of deep brain stimulation that adapts in real time to a person's movements, aiming to improve walking and motor skills in Parkinson's disease. Ten patients already scheduled for standard DBS surgery will receive this adaptive stimulation an…

This Phase 3 study tests an experimental drug called CVN424 in 330 people with Parkinson's disease who experience motor complications. Participants take either 75 mg, 150 mg, or a placebo pill once daily for 12 weeks. The main goal is to see if CVN424 can reduce the daily hours o…

This study tests a non-invasive treatment using focused ultrasound to target a small area in the brain that controls movement. It is for people with advanced Parkinson's disease whose medication no longer controls their involuntary movements or motor fluctuations. The goal is to …

This study tests a new gene therapy called LY3884961 in 32 people with moderate to severe Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as a single injection into the fluid around the brain and spinal cord. The main goal is to chec…

This study aimed to see if a special nutritional supplement (AMS2434) could help people with Parkinson's disease build stronger muscles and improve brain function. It was designed for adults aged 55 and older with mild to moderate Parkinson's. However, the study was withdrawn bef…

This study tests a new medicine called exidavnemab in people with mild to moderate Parkinson's disease or multiple system atrophy. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers …

This study tests a precise, non-invasive radiation treatment (frameless virtual cone radiosurgery) to reduce severe tremors in people with essential tremor or Parkinson's disease who cannot have deep brain stimulation. About 40 participants will receive a single focused dose of r…

This study tests a new approach to deep brain stimulation (DBS) for people with Parkinson's disease. Instead of the usual single electrode, researchers are placing electrodes in two brain areas and using a system that adjusts stimulation based on real-time brain signals. The goal…

This study tests a smart wearable airbag that detects when someone is falling and inflates to cushion the impact. It is designed for people at high risk of falling, such as those with stroke, Parkinson's disease, or a leg amputation. The goal is to see if the device can reduce fa…

This first-in-human trial tests a stem cell therapy called STEM-PD for Parkinson's disease. Eight participants with moderate Parkinson's will have dopamine-producing cells transplanted into a brain region affected by the disease. The main goal is to check safety over 12 months, w…

This study tests whether a daily dose of tocotrienols (a type of vitamin E) can slow the worsening of motor symptoms in Parkinson's disease. One hundred adults with Parkinson's will take either the supplement or a placebo for two years. Researchers will track movement, thinking, …

This study tests a vaccine called ACI-7104.056 in 150 people with early-stage Parkinson's disease. The goal is to see if it is safe and helps the body fight a protein linked to Parkinson's. Participants must already be on stable low-dose levodopa. This is not a cure, but may help…

This study is testing whether low-dose lithium aspartate, a dietary supplement, can slow the progression of Parkinson's disease. It involves 35 people who have already completed a lithium trial, and they will take lithium for another 24 weeks. Researchers will use brain scans and…

This program gave 10 people with Parkinson's disease, aged 76 to 95, multiple infusions of their own stored stem cells to check if it is safe. The treatment used 200 million cells given through an IV over 18 weeks, followed by 6 weeks of monitoring. The goal was safety, not a cur…

This expanded access program provides multiple intravenous infusions of a patient's own stem cells (HB-adMSCs) to up to 11 people with Parkinson's disease who were eligible for but not randomized into a related Phase 2 trial. The goal is to evaluate safety and effectiveness in co…

This study looks at whether adding physiotherapy to deep brain stimulation (DBS) can improve how people with Parkinson's disease move around their community. DBS helps with stiffness and tremors, but past studies found it didn't improve mobility and even increased falls. The tria…

This study tests a brain-computer interface that records brain activity and delivers stimulation to stop freezing of gait in people with Parkinson's disease. Ten participants who are already scheduled for deep brain stimulation surgery will have an additional electrode placed on …

This early-stage trial tests whether transplanting dopamine neurons made from a patient's own stem cells into the brain is safe for Parkinson's disease. Six people aged 55 to 80 with Parkinson's for at least 5 years will receive the cells in a single surgery. The main goal is to …

This study explores whether altering gut bacteria with an antibiotic (rifaximin) can improve motor symptoms and medication response in people with Parkinson's disease. Researchers will first analyze how gut bacteria relate to symptoms, then give some participants rifaximin and ot…

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can impr…

This study is looking for better ways to diagnose Parkinson's disease using samples that are easy to collect, like blood, skin, and nasal swabs. Researchers will compare these samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. The goal…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study tests whether alternating between high and low frequencies of deep brain stimulation (DBS) can improve walking and balance in people with Parkinson's disease. Twelve participants who already have DBS implants will try different stimulation patterns while their gait and…

This study tests a new functional drink made with chicory inulin, B-vitamins, and vitamin D to see if it can improve constipation and overall well-being in people with Parkinson's disease. About 56 participants will drink either the active supplement or a placebo twice daily for …

This study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…

This study tests a remote speech therapy program for 32 Korean-speaking people with Parkinson's disease and their families. The therapy includes 16 sessions over four weeks, plus daily home practice, to improve speech clarity. The goal is to see if this culturally adapted approac…

This study tests whether a 'social prescription' program can reduce loneliness in people with Parkinson's disease who already attend group exercise classes. About 40 participants who feel lonely will work with an occupational therapist to choose from 11 social activities, like sp…

This study tests whether adding motor imagery—mentally practicing movements without actually moving—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. Forty-two participants will be randomly assigned to receive either …

This study tests whether an 8-week aquatic high-intensity interval training (HIIT) program can improve balance, physical function, and muscle health in people with Parkinson's disease. Fifty-six participants with mild to moderate Parkinson's will do Tabata-style exercises in a po…

This study tests whether adaptive deep brain stimulation (DBS) can reduce or prevent freezing of gait in 20 people with Parkinson's disease. Participants already have DBS implants, and the device will adjust stimulation in real time based on brain signals. Freezing episodes will …

This study tests a wearable device that delivers gentle vibrations to the skin to improve motor function in people with Parkinson's disease. The treatment can be used alongside regular medication and aims to delay the need for higher doses. Thirty participants with moderate-stage…

This study tests a device called NervioX-2400 that uses weak electrical currents to stimulate specific brain areas without surgery. Researchers want to see if it can improve movement problems like tremors and stiffness in 100 people with early-to-mid stage Parkinson's disease. Ea…

This study tests whether a dietary fiber called resistant maltodextrin is safe and tolerable for people with Parkinson's disease. Half of the 30 participants will take the fiber, and the other half will take a control substance. Researchers will check for side effects and see if …

This study tests whether a personalized lifestyle program focusing on stress, exercise, nutrition, sleep, and self-management can improve quality of life for people with Parkinson's disease. 256 participants will be randomly assigned to either work on their goals independently or…

This study tests whether a 4-week telerehabilitation program can improve balance and quality of life in 36 people with multiple sclerosis or Parkinson's disease. Participants do balance exercises at home while monitored by a hospital physiotherapist. The results are compared to s…

This study tests two types of memory training in 120 people with Parkinson's disease and mild cognitive impairment. Participants complete 8 weekly sessions of either process or strategy training. The goal is to see if these exercises improve remembering to do tasks in daily life,…

This study tests whether manual therapy (specialized hands-on techniques by experienced physiotherapists) can improve both movement and non-movement symptoms in 60 people with Parkinson's disease. Participants receive up to two sessions per week for six weeks, alongside their usu…

This study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study tests whether combining two types of brain stimulation (tDCS and TUS) with physical therapy can improve balance in people with Parkinson's disease. Forty participants will receive either real or sham stimulation during therapy sessions over two weeks. The goal is to se…

This study tests an experimental drug called KDT-3594 in 150 people with advanced Parkinson's disease who already take levodopa. The goal is to see if the drug can improve movement and daily living skills during their 'on' times (when medication is working). Participants take esc…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake (sham) stimulation for 30 minutes over 10 sessions. The g…

This study explores whether wearing prismatic goggles that shift vision can improve emotional awareness (alexithymia) and visual-spatial abilities in people with Parkinson's disease. Researchers will also use brain scans and tear tests to understand how the brain adapts and to fi…

This study tests whether using advanced brain imaging to guide deep brain stimulation (DBS) can better control tremor in people with Parkinson's disease while avoiding side effects like involuntary movements. Twenty adults who already have DBS implants will have their stimulation…

This study tests whether a non-invasive brain stimulation technique called iTBS can reduce pain and other symptoms in people with Parkinson's disease. Researchers will compare two different stimulation patterns in 90 adults aged 40-80 who have had Parkinson's for at least 3 years…

This study is testing a device called MemorEM, which is a cap that sends low-level electromagnetic waves to the head. The goal is to get feedback from 1,000 patients with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, on how easy the device is to use…

This study tests whether a high-intensity interval training (HIIT) program can improve cognitive function and quality of life in people with Parkinson's disease. Researchers will enroll 30 participants aged 40 and older to exercise regularly for 3 to 6 months. The goal is to see …

This phase 2 trial tests whether taking 10 mg of melatonin daily for 12 weeks can reduce oxidative stress and improve symptoms in 70 people with mild-to-moderate Parkinson's disease who are already on levodopa. Participants will be randomly assigned to receive melatonin or a plac…

This study is testing whether a daily supplement made from baker's yeast can improve digestion and reduce gut symptoms in healthy adults aged 50 to 99. Participants take 15 grams of the supplement each day and report any changes in how their stomach feels. The goal is to see if t…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…

This study tests a special exercise program called TURN-IT for people with Parkinson's disease who have fallen in the past year. The program focuses on improving turning ability through targeted exercises. 55 participants will either do the program or continue usual care, and res…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on standard Parkinson's medication will use the light at home. The goal is to see if adding this light ther…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study tracks brain activity in 160 Parkinson's patients who have or will receive deep brain stimulation (DBS). Researchers record signals from the brain during memory tasks, with the stimulator on and off, to find patterns linked to cognitive side effects. The goal is to ide…

This study aims to identify genetic, biochemical, and clinical factors linked to disease severity in people with Gaucher disease and other lysosomal storage disorders. Researchers will evaluate up to 1,000 participants, including patients, carriers, and healthy controls, to bette…

This study tests a new type of brain implant that can both sense brain activity and deliver stimulation in real time. It involves 25 people with Parkinson's disease or dystonia who already need deep brain stimulation. The goal is to see if closed-loop stimulation (which adjusts a…

This study tracks the exercise habits of 288 people with Parkinson's disease over one year using activity trackers and a phone app. Researchers want to see if different types of exercise advice—like standard care, written guidance from a neurologist, or physical therapy—help peop…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This early-phase study tests whether a new type of PET scan can measure inflammation in the brains of people with Parkinson's disease. Researchers will compare scans from 11 participants (both with Parkinson's and healthy volunteers) to see if the imaging drug 18F-NOS can help di…

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…

This study looks at how things like social support, income, and health habits are linked to mental health and brain diseases such as depression, Alzheimer's, and Parkinson's. Researchers will collect surveys, blood samples, and optional brain scans from over 1,300 adults in Europ…

This study follows 200 people with Parkinson's disease or multiple sclerosis over one year to see how active they are. Participants use a smartphone app called Datos Health to track steps, workouts, and heart rate. A physical therapist sets personalized exercise goals. The goal i…

This early-phase study uses advanced MRI to visualize the brain's lymphatic system, which may help clear waste linked to Parkinson's and other brain diseases. Researchers will compare images from 140 people with and without Parkinson's to see if this system works differently in t…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test non-regular stimulation patterns to find ways to mak…

This study looks at whether small amounts of brain inflammation contribute to movement and thinking problems in people with Parkinson disease. Researchers will use a new radioactive tracer called [11C]-CS1P1 in PET scans to measure inflammation in the brain. The study includes 80…

This study aimed to collect brain signals related to speech from people with Parkinson's disease during deep brain stimulation (DBS) surgery. The goal was to better understand how the brain controls speech in these patients. However, the study was withdrawn before enrolling any p…

This study records brain activity from 125 Parkinson's patients during deep brain stimulation (DBS) surgery. Participants perform tasks that involve making decisions, stopping actions, or switching between actions. The goal is to understand how brain circuits control movement and…

This study follows 60 adults with Parkinson's disease who are scheduled for deep brain stimulation (DBS) surgery. Researchers will track their brain activity, movement, and thinking skills over time to learn how DBS affects the brain. The goal is to gather information, not to tes…

This study is testing whether adding action observation and motor imagery (watching and imagining exercises) to standard dual-task gait training can improve walking and balance in people with Parkinson's disease who have trouble with posture and walking. 80 participants will be r…

This study is analyzing blood samples from 1,799 people with Alzheimer's, dementia, depression, bipolar disorder, schizophrenia, or Parkinson's disease. Researchers want to see if certain substances in the blood can help doctors diagnose and manage these conditions more accuratel…

This study uses a small skin sample to measure levels of a protein linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 participants for 18 months to see if changes in the protein match disease progression. The goal is to develop a simple bio…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study looks at whether a device called GYKO can reliably measure balance in people with Parkinson's disease during walking tests. Twenty-five participants will perform two common balance tasks while wearing the device, and their results will be compared between two raters an…

This study looks at how certain cues (like visual or sound signals) help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to new…

This study will collect brain scans from over 10,000 healthy people in China to create standard brain charts. These charts will show what a normal brain looks like at different ages. Doctors can then compare a patient's brain scan to these charts to help diagnose diseases like mu…

This study follows 96 people with moderate Parkinson's disease for up to 24 months. Participants take their usual medications, and doctors may adjust them as needed. Researchers will track motor symptoms using standard rating scales to better understand how the disease progresses…

This study is testing whether rehabilitation that combines physical and mental exercises (called dual-task training) can help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will design and try out different dual-task strategies in small gr…

This study records brain activity in 40 Parkinson's patients during deep brain stimulation (DBS) surgery. While awake, patients perform movement tasks with sensory or motivational cues. The goal is to understand how the brain improves movement with these cues, which could guide f…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study aims to see if a special camera pill can safely take pictures of the esophagus in people with Parkinson's disease. Researchers want to find out if nerve changes in the gut can be seen and compared to healthy people. About 20 adults with Parkinson's will swallow a tiny …

This study tests whether two online educational sessions can help Parkinson's patients better understand deep brain stimulation (DBS) surgery. Sixty patients and their caregivers will attend virtual classes with expert talks and patient testimonials. The goal is to see if this im…

This study planned to use brain scans to measure how a meditation technique called OM affects dopamine and stress markers in people with Parkinson's disease. It was withdrawn before enrolling any participants, so no results are available. The goal was to better understand meditat…

This study explores whether low-intensity ultrasound can safely and precisely stimulate deep brain regions in people with Parkinson's disease or dystonia. Ten participants who already have deep brain stimulation (DBS) implants will receive ultrasound pulses while researchers reco…

This study is testing whether mobile EEG headsets, smartwatches, and other wearable devices can reliably measure sleep problems and disease progression in people with Parkinson's disease. About 82 participants will use these devices at home and complete tasks through a mobile app…

This study tests whether a wrist-worn movement recorder, called the Personal KinetiGraph (PKG), helps doctors make better treatment decisions for people with Parkinson's disease. About 231 participants will be split into two groups: one where the doctor sees the PKG data during t…