PARKINSON DISEASE

This early-stage trial tests the safety of a new treatment called ANPD001 for people with Parkinson's disease. The treatment uses a patient's own skin cells to create new dopamine-producing cells, which are then injected into the brain. The study involves 9 participants and aims …

This study tests a non-invasive procedure called focused ultrasound to treat severe movement problems in people with advanced Parkinson's disease. About 92 participants will receive a one-time treatment that uses sound waves to target a small area in the brain. The goal is to red…

This study tests an experimental drug called BIIB122 in 650 people with early-stage Parkinson's disease. The goal is to see if the drug can slow down the worsening of symptoms like movement and daily living tasks. Participants take a daily tablet for up to 3 years, and researcher…

This early-stage trial tests whether transplanting lab-grown dopamine-producing cells into the brain is safe for people with Parkinson's disease. Eight participants with moderate Parkinson's will receive a single dose of these stem cells. The study focuses on safety and looks for…

This early-stage trial tests the safety of transplanting dopamine neurons made from a patient's own stem cells into the brain to treat Parkinson's disease. Six people with Parkinson's will receive the transplant and be monitored for side effects and motor function changes. The go…

This study tests a smart wearable airbag that inflates when it senses a fall, cushioning the impact to prevent injury. Researchers are enrolling 200 people at high risk of falling, including those with stroke, Parkinson's, or leg amputation. The goal is to see if the device works…

This study is testing whether low-dose lithium can slow the progression of Parkinson's disease. It involves 35 people who have already completed a previous lithium trial. Over 24 weeks, researchers will use brain scans and blood tests to look for changes in disease markers. The g…

This program offers multiple intravenous infusions of a patient's own stem cells (HB-adMSCs) to up to 11 people with Parkinson's disease who were not chosen for a related Phase 2 study. The goal is to see if the treatment is safe and can help control symptoms. It is not a cure, b…

This study looks at how deep brain stimulation (DBS) surgery helps people with Parkinson's disease move better and feel more independent. Researchers will measure walking speed, balance, muscle strength, and fear of falling in 40 adults before and after surgery. The goal is to se…

This early-stage study tests a gene therapy called LY3884961 in 32 people with moderate to severe Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as a single injection into the fluid around the brain and spinal cord. The main goals a…

This study tested the safety of giving stem cells through an IV to 10 people aged 76-95 with Parkinson's disease. The treatment involved multiple infusions over 18 weeks, using the patients' own stored stem cells. The goal was to see if this approach is safe, not to cure the dise…

This Phase 3 study tests an experimental oral drug, CVN424, in 330 people with Parkinson's disease who experience motor complications (fluctuations between 'ON' and 'OFF' periods). Participants take either a low or high dose of CVN424 or a placebo daily for 12 weeks. The main goa…

This study aimed to test a nutritional supplement called AMS2434, made from essential amino acids, in people with Parkinson's disease. The goal was to see if it could improve muscle protein building, brain chemical balance, and mood or thinking. The study was withdrawn before any…

This study tests a new medicine called exidavnemab in people with mild to moderate Parkinson's disease or multiple system atrophy (MSA). The main goal is to check if the drug is safe and tolerable. Participants will receive either the drug or a placebo, and researchers will monit…

This study tests an experimental vaccine called ACI-7104.056 in 150 people with early-stage Parkinson's disease. The vaccine aims to train the immune system to target a protein linked to Parkinson's. The main goals are to check safety and see if the vaccine produces the desired i…

This study tests a precise, non-invasive radiation treatment called frameless virtual cone radiosurgery for people with severe tremor from essential tremor or Parkinson's disease who cannot have deep brain stimulation. The goal is to reduce tremor and improve daily activities. Fo…

This early-phase study tests whether using alternating-frequency deep brain stimulation (DBS) can improve walking and balance problems in people with Parkinson disease. The study involves 12 participants who already have DBS implants. Researchers will measure changes in gait stab…

This study is for people with Parkinson's disease who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to see if placing electrodes in two different brain areas (instead of one) can better control symptoms. They also aim to develop a smart DBS syst…

This study explores whether altering the gut microbiome can improve how people with Parkinson's disease respond to their medication. Researchers will first analyze gut bacteria in 86 participants, then give some antibiotics to reset the microbiome. The goal is to reduce 'OFF' tim…

This study tests whether a daily supplement called tocotrienol (a form of vitamin E) can slow the worsening of movement problems in people with Parkinson's disease. One hundred adults with Parkinson's will take either the supplement or a placebo for two years. Researchers will tr…

This study looks at whether online palliative care training for doctors and telemedicine support can improve quality of life for people with Parkinson's disease, Lewy body dementia, and similar conditions, as well as their caregivers. About 632 patients and their care partners ar…

This study tests whether a daily 1-hour session of gamma flickering light is safe and tolerable for people with Parkinson's disease who experience freezing of gait — a feeling that their feet are glued to the floor. The study involves 24 participants aged 50-80 who will use a lig…

This study tests a new type of deep brain stimulation that adapts in real time to prevent freezing of gait in people with Parkinson's disease. Twenty participants will use wearable devices at home to track their walking. The goal is to see if this smart stimulation can reduce or …

This study tests whether a non-invasive brain stimulation technique (tDCS plus ultrasound) combined with physical therapy can help improve balance problems in people with Parkinson's disease. Forty adults with Parkinson's who have trouble with balance will receive either real or …

This study tests whether an 8-week aquatic high-intensity interval training (HIIT) program can improve balance, physical function, and muscle health in people with Parkinson's disease. Fifty-six participants with mild to moderate Parkinson's will do water-based Tabata-style exerc…

This study tests whether doing physical therapy sessions at home through video calls can improve balance and quality of life for people with multiple sclerosis or Parkinson's disease. Thirty-six participants will complete 20 balance-training sessions either via telerehabilitation…

This small pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease who have memory or thinking problems. Ten participants will work one-on-one with a coach in nine virtual sessions, lear…

This pilot study tests whether a high-intensity interval training (HIIT) program can improve cognitive function and quality of life in 30 people with Parkinson's disease. Participants will exercise regularly for 3 to 6 months, and researchers will measure changes in memory, atten…

This study tests a new functional drink designed to help with constipation, a common problem for people with Parkinson's disease. The drink contains extra fiber (inulin) and key vitamins like B-vitamins and vitamin D. Over 12 weeks, 56 participants will drink it and researchers w…

This study looks at whether manual therapy (a type of hands-on treatment) can improve both movement and non-movement symptoms in people with Parkinson's disease. Sixty adults aged 40 to 75 will receive up to two therapy sessions per week for at least six weeks, in addition to the…

This study tests a new drug, KDT-3594, in 150 people with advanced Parkinson's disease who already take levodopa. The goal is to see if the drug can improve movement and daily living skills over 17 weeks. Participants receive either the study drug or a placebo, and researchers me…

This study compares two different motor-cognitive rehabilitation programs for people with Parkinson's disease who have balance and walking difficulties. Eighty participants will be assigned to either a dual-task training combined with action observation and motor imagery, or dual…

This study tests a special exercise program called TURN-IT designed to improve how people with Parkinson's disease turn, which is a common cause of falls. About 55 participants with Parkinson's and a history of falls will either do the 6-week program or continue as usual. The goa…

This study tests if a gentle nerve stimulation device, timed with your breathing, can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty adults with stable medication will try three different stimulation patterns over three 2-week cycles. The…

This study tests whether advanced brain imaging can help doctors fine-tune deep brain stimulation (DBS) in people with Parkinson's disease who already have DBS implants. The goal is to better control tremors while avoiding unwanted movements (dyskinesia). Twenty participants will…

This small study tests whether using inflatable cuffs on the legs (blood flow restriction) during low-intensity stepping exercise can improve mobility and quality of life in people with advanced Parkinson's disease. Four participants will exercise twice a week for 8 weeks on a Nu…

This study tests a brain-machine interface that records and stimulates brain activity to reduce freezing of gait in people with Parkinson's disease. Ten participants already scheduled for deep brain stimulation surgery will receive an additional brain implant. The goal is to dete…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants will use the light therapy at home while continuing their regular medications. The goal is to see if adding light therapy h…

This study tests whether taking melatonin (10 mg at bedtime) for 12 weeks can improve symptoms and reduce oxidative stress in people with mild-to-moderate Parkinson's disease who are already taking levodopa. 70 participants will be randomly assigned to receive melatonin or a plac…

This study tests a non-invasive device that delivers gentle vibrations to the skin to improve motor function in 30 people with Parkinson's disease. The treatment can be used alongside medication and aims to reduce the need for higher doses. It offers a flexible alternative to dee…

This study tests a non-invasive brain stimulation method called tTIS in 100 people with early to mid-stage Parkinson's disease. It compares the immediate effects of stimulating two different brain areas (STN and GPi) on movement symptoms like tremor and stiffness when medication …

This study tests whether a gentle brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake tDCS for 30 minutes over 10 sessions. The goal is to see if the…

This study tests whether a 12-month program focusing on stress, exercise, nutrition, sleep, and self-management can improve quality of life for people with Parkinson's disease. 256 participants will either work on their goals independently or with a lifestyle coach. The main outc…

This study tests two types of memory training for people with Parkinson's disease and mild memory problems. 120 participants will complete 8 training sessions over 8 weeks and be followed for a year. The goal is to see if these programs improve everyday memory and help people rea…

This study looks at whether adding physiotherapy to deep brain stimulation (DBS) helps people with Parkinson's disease move around more safely and independently in their communities. DBS is a brain surgery that improves stiffness, slowness, and tremors, but it hasn't been shown t…

This study tests whether a dietary fiber called resistant maltodextrin is safe and tolerable for people with Parkinson's disease. It also looks at whether the fiber can change gut bacteria and possibly improve movement and non-movement symptoms. Half of the 30 participants get th…

This study is testing a set of virtual reality games (exergames) in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. The games include cooking together, solvi…

This study collects movement data from 250 people with stroke, Parkinson's, or leg amputations using wearable sensors and video. The goal is to create a database that researchers can use to better understand movement and rehabilitation. Participants range from newborns to 99 year…

This study looks at how certain cues, like visual or auditory signals, help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to …

This study was designed to learn how the brain controls speech in people with Parkinson's disease who are getting deep brain stimulation (DBS). Researchers planned to record brain signals during DBS surgery while participants performed speech tasks. The study was withdrawn before…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test various stimulation patterns to find which ones work best for…

This early-stage study tests a new type of brain stimulation that adapts in real-time to improve walking in people with Parkinson's disease. Ten participants will have their brain activity recorded during walking tasks to find the best way to deliver stimulation. The goal is to d…

This study is testing how well wearable devices like mobile EEG headsets and smartwatches can measure sleep problems and symptoms in people with Parkinson's disease. Researchers want to see if these tools are easy to use and if they can help discover new biological markers. About…

This study aims to find genetic, biochemical, and clinical factors that affect how severe Gaucher disease and other lysosomal storage disorders become. Up to 1,000 participants, including patients, carriers, and healthy volunteers, will be evaluated yearly. The goal is to better …

This study follows 96 people with moderate Parkinson's disease to see how their symptoms change over 3 to 24 months. Participants continue their usual medications, and doctors may adjust them for better symptom control. The study does not test a new treatment but aims to better u…

This study aims to understand how the brain controls actions like stopping or switching tasks in people with Parkinson's disease. Researchers will record brain activity during deep brain stimulation (DBS) surgery while patients perform simple tasks. The goal is to learn more abou…

This study explores whether combining physical and mental tasks (like walking while solving a puzzle) can improve rehabilitation for people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will test these strategies in small groups to see if they a…

This study follows 200 people with Parkinson's disease or multiple sclerosis for one year. Participants use a smartphone app to track their daily steps and exercise. The goal is to learn how physical activity and confidence in exercising change over time, without providing any tr…

This study asks 1,000 people with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, to share their experiences using a head device called MemorEM. The goal is to learn how to make the device better and easier to use in future studies. No treatment is gi…

This study looks at how things like social support, income, and habits affect mental health and brain diseases. About 1,310 adults in Europe, including those with depression, schizophrenia, bipolar disorder, Alzheimer's, Parkinson's, or dementia, will answer surveys and have brai…

This study looks at brain activity during Deep Brain Stimulation (DBS) surgery in 160 people with Parkinson's disease. The goal is to find brain signals that show when thinking or memory problems might happen. By understanding these signals, doctors hope to place the electrodes b…

This study tests a computer program that uses brain scans to tell apart Parkinson's disease from two similar conditions. About 315 people with these diagnoses will get an MRI and a checkup at one of 21 medical centers. The computer's diagnosis will be compared to the opinion of t…

This early-phase study tests whether a special PET scan using a tracer called 18F-NOS can measure inflammation in the brains of people with Parkinson's disease. Eleven participants, including both Parkinson's patients and healthy volunteers, will receive the scan to compare brain…

This study looks for biological markers of Parkinson's disease in blood, nasal mucus, and skin samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. Researchers aim to find patterns that could help diagnose the disease earlier and track i…

This study follows 60 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery. Researchers will collect detailed information on brain activity, thinking skills, and movement before, during, and after the procedure. The goal is to learn how DBS affe…

This study tested whether a special watch (Personal KinetiGraph) that records movement can help doctors make better treatment decisions for people with Parkinson's disease. About 231 participants were split into two groups: one where doctors saw the watch data, and one where they…

This study aims to learn more about symptoms of brain diseases like Parkinson's and frontotemporal dementia. Researchers will track 500 adults over time using brain scans and genetic analysis to see how the disease changes. The goal is to better understand these conditions, not t…

This early-phase study uses advanced MRI to measure how well the brain clears waste fluids in people with Parkinson's disease compared to healthy volunteers. The goal is to develop better imaging methods to understand the brain's lymphatic system, which may play a role in Parkins…

This study checks if a device called GYKO can reliably measure balance in 25 people with Parkinson's disease (stages 1-3). Participants will perform walking and turning tests while wearing the sensor, and the results will be compared between two raters and again one week later. T…

This study involves 40 people with Parkinson's disease who are already scheduled for deep brain stimulation (DBS) surgery. During the surgery, while they are awake, researchers will record brain activity as they perform movement tasks with different cues. The goal is to understan…

This study aimed to see if a special meditation technique called orgasmic meditation (OM) could change brain activity in people with Parkinson's disease. Researchers planned to use brain scans (PET and MRI) to measure dopamine and inflammation. The study was withdrawn before any …

This study aims to see if a special pill-sized camera can safely take pictures of the esophagus in people with Parkinson's disease. Researchers want to find out if the nerves in the gut look different in Parkinson's patients compared to healthy people. About 20 adults with Parkin…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to movement and attention. The goal is to understand why some patients develop w…

This study looks at how people with Parkinson's Disease exercise over a year. Researchers want to see if different types of guidance—like standard care, written advice from a neurologist, or physical therapy—can help people be more active. Participants will wear activity trackers…

This study is analyzing blood samples from 1,799 people with brain diseases (like Alzheimer's, dementia, depression, and schizophrenia) and healthy volunteers. Researchers want to see if certain substances in the blood can help doctors diagnose these conditions more accurately. T…

This study aims to measure inflammation in the brains of people with Parkinson disease using a new radioactive tracer called [11C]-CS1P1 during a PET scan. Researchers believe this inflammation may contribute to movement and thinking problems. The study will compare 80 participan…

This study explores whether low-intensity ultrasound can safely and effectively stimulate deep brain areas in people with Parkinson's disease or dystonia. Ten adults who already have implanted deep brain stimulation (DBS) leads will receive ultrasound pulses while researchers rec…

This study looks at whether a technique called prismatic adaptation (using special lenses that shift vision) can help people with Parkinson's disease improve their ability to recognize emotions and perform visual tasks. About 126 participants will try this method, and researchers…

This study looks at whether an online educational session can help people with Parkinson's disease who are considering deep brain stimulation (DBS) surgery. The goal is to help patients and their families set realistic expectations about the surgery's benefits and risks. Sixty pa…

This study looks at whether a small skin sample can measure a protein called phosphorylated alpha-synuclein, which is linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 adults aged 50 to 85 for 18 months to see if changes in this protein ma…

This study aimed to understand how blood pressure changes when standing up affect thinking skills and brain blood flow in people with Parkinson's disease. Researchers planned to compare those with and without orthostatic hypotension (low blood pressure upon standing) using cognit…

This study aims to understand if variations in a specific gene (AQP4), which helps the brain clear waste during sleep, are linked to how Parkinson's disease symptoms appear and progress. Researchers will collect blood samples and conduct clinical assessments from 800 people with …