PARKINSON DISEASE

This study aims to improve deep brain stimulation (DBS) for Parkinson's disease by using detailed maps of the brain's wiring. Researchers will test if targeting specific brain pathways can better control tremor while avoiding side effects like involuntary movements. The study inv…

This expanded access program allowed up to 11 patients with early to moderate Parkinson's disease to receive their own banked stem cells intravenously. The trial aimed to evaluate whether these stem cells could help control Parkinson's symptoms and slow disease progression. Parti…

This study explores whether changing the gut bacteria in people with Parkinson's disease can improve their symptoms and make their medication work better. Researchers will first examine how gut bacteria relate to symptoms, then test if using antibiotics to reset gut bacteria help…

This study is testing a new type of deep brain stimulation (DBS) system for people with severe Parkinson's disease. The research has two main goals: to compare the effects of stimulating two different areas of the brain, and to develop a 'closed-loop' system that can automaticall…

This study is testing whether a natural form of vitamin E called tocotrienols can help slow the progression of Parkinson's disease. Over two years, 100 Parkinson's patients will take either the supplement or a placebo pill daily. Researchers will measure changes in movement, thin…

This study is testing an experimental vaccine called ACI-7104.056 in people with early Parkinson's disease. The main goals are to check if the vaccine is safe and to see if it triggers an immune response against a harmful brain protein linked to Parkinson's. About 150 participant…

This study aimed to test a nutritional supplement called AMS2434, designed to help build muscle and support brain chemistry in people with Parkinson's disease. It planned to measure if the supplement could boost muscle growth and improve mood and thinking in older participants. H…

This study is testing a non-surgical procedure that uses focused sound waves to create a small, precise lesion in a part of the brain involved in Parkinson's movement problems. It aims to help people with advanced Parkinson's whose involuntary movements (dyskinesia) or motor fluc…

This is an early-stage study testing a new gene therapy called LY3884961 for people with moderate to severe Parkinson's disease who have a specific genetic mutation (GBA1). The therapy is delivered via a single injection into the fluid around the brain and spinal cord. The main g…

This study is testing whether an experimental drug called BIIB122 can slow down the worsening of Parkinson's disease symptoms. Researchers are enrolling 650 adults with early-stage Parkinson's (diagnosed within 2 years) to take either the drug or a placebo pill daily for 1 to 3 y…

This study continues testing if low-dose lithium can slow Parkinson's disease progression. It enrolls 35 patients who have already finished a prior 24-week lithium trial. Researchers will adjust each person's lithium dose to reach a specific target level in the blood for another …

This trial is testing a new daily medicine called KDT-3594 for people with advanced Parkinson's disease who are already taking levodopa. The main goal is to see if it can better control movement symptoms and reduce the amount of time when medication wears off ('off' time). About …

This study is testing whether adding melatonin, a common sleep supplement, to standard Parkinson's medication (levodopa) can help control the disease better. Researchers will give 70 patients with mild to moderate Parkinson's either melatonin or a placebo pill nightly for 12 week…

This study is testing the safety and how the body processes a new drug called exidavnemab in people with mild to moderate Parkinson's disease or multiple system atrophy. About 38 participants will receive either the drug or a placebo to see how well it is tolerated. The main goal…

This study is testing if adding physical therapy to a common Parkinson's brain surgery helps people move around their community more safely and independently. Researchers are comparing 60 people who get the surgery plus physical therapy to those who get the surgery alone. The goa…

This early-stage study is testing a new treatment for Parkinson's disease. Researchers will take a small blood sample from each patient, grow new dopamine brain cells from it in a lab, and then transplant those cells back into the patient's brain. The main goal is to see if this …

This program tested the safety of using a patient's own stem cells to treat Parkinson's disease. It was for 10 older patients (ages 76-95) who had already banked their cells with the research sponsor. The main goal was to see if giving multiple IV infusions of these cells over 18…

This study is testing a brain-machine interface to help people with Parkinson's disease who experience 'freezing of gait'—sudden, temporary inability to move their feet while walking. Researchers will implant electrodes on the brain's surface to detect the abnormal brain activity…

This is the first-ever study in people to test a new stem cell therapy for Parkinson's disease. The goal is to see if transplanting lab-grown cells that can produce dopamine—a brain chemical lost in Parkinson's—directly into the brain is safe. Eight participants with moderate Par…

This study is testing a new computer software tool that analyzes brain scans to help doctors tell the difference between Parkinson's disease and similar movement disorders. Researchers at 21 medical centers are comparing the tool's accuracy against diagnoses made by expert neurol…

This study is testing a smart wearable airbag system designed to prevent injuries from falls. The device uses sensors and computer algorithms to detect when someone is falling and quickly inflates an airbag to cushion the impact, aiming to reduce hip fractures. Researchers are te…

This small pilot study is testing whether a home-based coaching program originally developed for epilepsy can help people with Parkinson's disease. Participants attend nine virtual sessions with a coach to learn self-management strategies for memory and thinking problems. The mai…

This study tests whether rhythm-based training using music or singing can improve walking problems in people with Parkinson's disease. For 12 weeks, participants will practice walking to music or walking while singing to see which approach works better. Researchers will measure w…

This study is testing whether a specialized light therapy device can help improve daily life and movement symptoms for people with Parkinson's disease. Participants use a tablet-like light device at home for one hour each evening while doing normal activities. The research aims t…

This study is testing whether a non-invasive brain stimulation technique called temporal interference stimulation (tTIS) can improve movement symptoms in people with early to mid-stage Parkinson's disease. Researchers will compare stimulation of two different brain areas to see w…

This study is testing whether switching between two different frequencies of deep brain stimulation (DBS) can help improve walking, balance, and reduce falls in people with Parkinson's disease. Researchers are working with 12 participants who already have a specific type of DBS i…

This study is testing whether fun virtual reality games in a shared online world (the metaverse) can help people with brain injuries or diseases like stroke, MS, or Parkinson's. The games focus on cooking, puzzles, and social activities to improve memory, attention, and thinking …

This study is testing a non-surgical radiation treatment for people with severe, medication-resistant hand tremor from Parkinson's disease or Essential Tremor. It is for patients who are not good candidates for or do not want deep brain stimulation surgery. The treatment uses pre…

This study is testing whether a 'smart' deep brain stimulation system can reduce or prevent freezing of gait—a sudden, temporary inability to walk—in people with Parkinson's disease. Researchers will compare a new, personalized stimulation setting that adjusts in real-time to the…

This study is testing two different training methods to help people with Parkinson's disease who have mild memory problems. The goal is to improve their ability to remember to do everyday tasks, like taking medication or attending appointments. About 120 participants will complet…

This study is testing whether daily exposure to a special flickering light and sound, called gamma sensory flicker, is safe and can help reduce 'freezing of gait' in people with Parkinson's disease. Freezing of gait is when a person's feet feel stuck to the floor, which is a majo…

This study aims to find out which of two different rehabilitation programs works better to improve walking, balance, and thinking in people with Parkinson's disease who have these problems. Researchers will use brain scans and blood tests to try to predict which patients will res…

This study is testing whether online training for community neurologists and telemedicine support services can improve quality of life for people with Parkinson's disease, Lewy Body Dementia, and related conditions, and reduce the burden on their caregivers. It involves over 600 …

This study is testing a gentle, non-invasive stimulation device placed on the ear to see if it can help improve movement problems and other symptoms like low mood, tiredness, and poor sleep in people with Parkinson's disease. Researchers will compare three different patterns of s…

This small, early-stage study is testing a new exercise method for people with advanced Parkinson's disease. Four participants will do light leg-stepping exercises while wearing special cuffs on their thighs that gently reduce blood flow. Researchers want to see if this 8-week pr…

This study is testing whether a specific type of hands-on manual therapy can help improve symptoms for people with Parkinson's disease. Over 6 weeks, 60 participants will receive up to two therapy sessions per week in addition to their regular care. Researchers will measure chang…

This study is testing new rehabilitation exercises that combine physical and mental tasks, like walking while solving a puzzle, to help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. The goal is to see if these 'dual-task' exercises, often supported b…

This study is testing whether combining two types of non-invasive brain stimulation with standard physical therapy can better improve balance and stability in people with Parkinson's disease. Researchers are comparing the combined treatment to physical therapy alone in a small gr…

This study is testing a specially designed nutritional drink to see if it can help with constipation, a common and troublesome symptom for people with Parkinson's disease. Over 12 weeks, 56 participants will drink this supplement, which is enriched with a type of fiber and key vi…

This small pilot study is testing whether a high-intensity interval training (HIIT) exercise program can help improve thinking skills and quality of life for people with Parkinson's disease. Over 3 to 6 months, researchers will compare a group doing HIIT classes three times a wee…

This study is testing whether wearing special glasses that shift vision, or using a virtual reality version of them, can help people with Parkinson's disease better judge distances and recognize their own emotions. Researchers will measure brain activity during the tasks and also…

This study is testing a new 6-week exercise program called TURN-IT, designed to help people with Parkinson's disease turn more safely in daily life. It involves 55 participants with Parkinson's who have a history of falls, practicing specific exercises three times a week. The goa…

This study is testing whether a gentle, non-invasive brain stimulation technique can help ease depression and other non-motor symptoms in people with Parkinson's disease. Participants receive either real or sham stimulation for 30 minutes over 10 sessions. The main goal is to see…

This study is testing whether a wrist-worn movement tracker, called the Personal KinetiGraph (PKG), helps doctors make better decisions about Parkinson's disease treatment. About 230 people with Parkinson's are participating. Half of their doctors will use the tracker's data duri…

This study aims to check if a small wearable sensor called GYKO can reliably measure balance problems during walking tests in people with Parkinson's disease. Researchers will have 25 participants with mild to moderate Parkinson's perform simple walking and turning tests while we…

This study is looking at whether simple blood tests can help doctors diagnose brain diseases like Alzheimer's, dementia, depression, and schizophrenia more quickly and accurately. Researchers will analyze blood samples from about 1,800 people who already have these conditions, al…

This study aimed to understand how a specific meditation practice might affect brain chemistry and activity in people with Parkinson's disease. Researchers planned to use brain scans (PET and MRI) to measure dopamine function and markers of stress in the brain before and after me…

This study aims to understand how different cues—like visual targets, rhythmic sounds, or rewards—help Parkinson's patients move more easily. Researchers will use brain scans (MRI) and brain wave recordings (EEG) on 90 participants (60 with Parkinson's, 30 healthy) while they per…

This study is testing whether online educational sessions help Parkinson's disease patients better understand deep brain stimulation (DBS) surgery before their procedure. Researchers want to see if virtual group sessions with experts and patient stories improve knowledge and set …

This study aims to find biological markers, or 'fingerprints,' for Parkinson's disease using easy-to-collect samples like blood and nasal tissue. Researchers will analyze samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers, to see if spe…

This study aims to understand how the brain controls actions like stopping or switching movements, which is often impaired in Parkinson's disease. Researchers will record brain activity directly from 125 Parkinson's patients during their scheduled deep brain stimulation surgery w…

This study aims to understand why some Parkinson's patients experience memory problems after receiving Deep Brain Stimulation (DBS) therapy. Researchers will measure brain activity in 160 patients during and after their DBS surgery to identify specific signals linked to these cog…

This study is exploring whether a new, non-invasive technique using focused ultrasound can safely stimulate deep brain areas in people with Parkinson's disease and dystonia. Researchers are testing this on a small group of patients who already have surgically implanted brain stim…

This study aims to better understand Gaucher disease and related lysosomal storage disorders by observing how symptoms and genetics vary among 1,000 patients over many years. Researchers will track participants annually to identify factors linked to disease severity and explore t…

This study aims to learn more about how the brain works during speech and movement in people with Parkinson's disease who are undergoing deep brain stimulation (DBS) surgery. Researchers will record brain activity during the procedure to gather data. The goal is to use this infor…

This study aims to understand why certain cues, like sounds or visual prompts, can help people with Parkinson's disease move more easily. Researchers will record brain activity from 40 patients during their scheduled deep brain stimulation (DBS) surgery while they perform simple …

This study aims to collect detailed information from Parkinson's disease patients who are getting deep brain stimulation (DBS) surgery. Researchers will track 60 patients over time, gathering data on their brain function, movement, and thinking skills before surgery, during the p…

This study aims to gather feedback from patients with neurological diseases like Alzheimer's and Parkinson's about their experience using the MemorEM head device. About 1,000 patients and their caregivers will share their thoughts through monthly surveys to help improve the devic…

This study is testing whether a small skin biopsy can measure a protein linked to Parkinson's disease. Researchers will follow 100 people with Parkinson's or a related sleep disorder for 18 months, taking skin samples and tracking their symptoms. The goal is to see if changes in …

This study aims to understand if gut problems in Parkinson's disease are linked to visible changes in the nerves of the esophagus. Researchers will test a new, swallowable camera that takes microscopic pictures of the esophagus in 20 people with Parkinson's. The goal is to see if…

This large European study aims to understand how social and economic factors—like income, education, and social support—affect mental health and brain biology. Researchers will follow over 1,300 adults, including people with conditions like depression, schizophrenia, Alzheimer's,…

This study aims to better understand how various brain diseases progress over time. Researchers will follow about 500 adults with symptoms of conditions like Parkinson's disease or dementia for several years. Participants will have yearly check-ups that may include brain scans, m…

This study aims to understand how changes in specific brain chemicals over time relate to walking difficulties, balance problems, and cognitive changes in people with Parkinson's disease. Researchers will use special brain scans (PET imaging) at the start of the study and again t…

This study aims to observe how people with moderate Parkinson's disease fare over time while on their usual medications. It will follow 96 participants for up to 2 years, tracking their movement symptoms during 'off' periods when medication wears off. A key goal is to see if part…

This study aims to test how well wearable devices and a mobile app can track sleep and brain activity in people with Parkinson's disease over 12 months. It will involve 82 adults with early-stage Parkinson's to see if these tools are easy to use and can provide reliable data. The…

This study aims to understand if variations in a specific gene (AQP4), which helps the brain clear waste during sleep, are linked to how Parkinson's disease symptoms appear and progress. Researchers will collect blood samples and conduct clinical assessments from 800 people with …