Could a common sleep aid ease Parkinson's symptoms?
NCT ID NCT07375693
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether taking 10 mg of melatonin daily for 12 weeks can reduce oxidative stress and improve symptoms in 70 people with mild-to-moderate Parkinson's disease who are already on levodopa. Participants will be randomly assigned to receive melatonin or a placebo, and researchers will measure blood markers of oxidative stress and inflammation, as well as symptom scores. The goal is to see if this widely available sleep supplement offers additional benefits beyond standard treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
melatonin
What this could lead to
If it works, this could point toward a simple, low-cost way to ease Parkinson's symptoms and slow disease progression by reducing oxidative stress.
What could go wrong
This is a small, early-phase trial with only 70 participants over 12 weeks. Melatonin is generally safe, but it may not provide meaningful symptom improvement or affect long-term disease course.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bangladesh medical university
Dhaka, Dhaka Division, 1212, Bangladesh