Brain pacemaker that learns: new trial aims to personalize Parkinson's treatment
NCT ID NCT03815656
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new approach to deep brain stimulation (DBS) for people with Parkinson's disease. Instead of the usual single electrode, researchers are placing electrodes in two brain areas and using a system that adjusts stimulation based on real-time brain signals. The goal is to see if this 'adaptive' DBS can better control symptoms like tremors and stiffness. The trial involves 46 participants who are already scheduled for DBS surgery and will be followed for up to 6 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- deep brain stimulation (DBS) device
- What this could lead to
- If successful, this could lead to more effective, personalized DBS therapy that adapts in real time to brain signals, potentially improving symptom control for Parkinson's patients.
- What could go wrong
- This is an early-stage study with only 46 participants, and adaptive DBS is still experimental. It may not work better than standard DBS, and there are surgical risks from electrode implantation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Other studies related to the condition(s) this trial covers.
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