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Personalized brain maps could make Parkinson's stimulation more precise

NCT ID NCT06618157

Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study tests whether using advanced brain imaging to guide deep brain stimulation (DBS) can better control tremor in people with Parkinson's disease while avoiding side effects like involuntary movements. Twenty adults who already have DBS implants will have their stimulation settings optimized based on individual brain pathways. The goal is to see if this personalized approach improves tremor control compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep brain stimulation (DBS) device
What this could lead to
If it works, this could lead to more precise DBS settings that better control tremor and avoid worsening involuntary movements in Parkinson's patients.
What could go wrong
This is a small, early-stage study with only 20 participants, so results may not apply to everyone. The approach is still experimental and may not improve symptoms for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 or older * Diagnosed with Parkinson's disease and has previously been implanted with bilateral subthalamic nucleus deep brain stimulation (DBS) * Received DBS at least three months prior to the time of the study to allow for optimization of usual clinical care * With at least mild tremor on a pre-operatory MDS-UPDRS clinical scale as defined by at least 2 out of 4 resting tremor grading on MDS-UPDRS on at least one extremity Exclusion Criteria: * Not having a post-operative head CT with 1mm or smaller axial slices at least 1 week after initial lead implantation. * Patients who received DBS less than three months prior to the start of the study

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Conditions

The condition(s) this trial relates to.

Dyskinesias Parkinson disease Tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dyskinesias Parkinson disease Tremor

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Duke Health Center at Morreene Road

    Durham, North Carolina, 27705, United States

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