AI reads brain scans to spot Parkinson's lookalikes

NCT ID NCT05913687

Ongoing Diagnosis Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can improve diagnostic accuracy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: machine learning algorithm of imaging data
What this could lead to: If successful, this could provide doctors with a reliable, automated way to distinguish between Parkinson's disease and similar conditions using MRI scans.
What could go wrong: This is a diagnostic accuracy study, not a treatment trial. The tool may not outperform specialist diagnosis in real-world settings, and results may not apply to all patient populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy multiple system atrophy, parkinsonian type Parkinson disease progressive supranuclear palsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SYSTEM ATROPHY, PARKINSON VARIANT PARKINSON DISEASE PROGRESSIVE SUPRANUCLEAR PALSY

Contacts and locations

Locations

Albany Medical College

Albany, New York, 12020, United States
Augusta University

Augusta, Georgia, 30912, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Centre for Addiction and Mental Health

Toronto, M5T 2S8, Canada
Duke University Medical Center

Durham, North Carolina, 22705, United States
Johns Hopkins University

Lutherville, Maryland, 21093, United States
Massachusetts General Hospital

Charlestown, Massachusetts, 02129, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ottawa Hospital Research Institute

Ottawa, K1Y 4E9, Canada
Pennsylvania State University

Hershey, Pennsylvania, 17033, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California San Diego

La Jolla, California, 92037, United States
University of California San Francisco

San Francisco, California, 94158, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Florida

Gainesville, Florida, 32611, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Michigan

Ann Arbor, Michigan, 48106, United States
University of Minnesota

Minneapolis, Minnesota, 55414, United States
University of South Florida

Tampa, Florida, 33613, United States
Wake Forest University

Winston-Salem, North Carolina, 27157, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States

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