New pill aims to cut Parkinson's 'OFF' time in major trial

NCT ID NCT06553027

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 25 times

Summary

This Phase 3 study tests an experimental oral drug, CVN424, in 330 people with Parkinson's disease who experience motor complications (fluctuations between 'ON' and 'OFF' periods). Participants take either a low or high dose of CVN424 or a placebo daily for 12 weeks. The main goal is to see if the drug reduces daily 'OFF' time (when symptoms return) and increases 'ON' time without troublesome involuntary movements.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PARKINSON DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • Atlanta Neuroscience Institute

    Atlanta, Georgia, 30327, United States

  • Axon Clinical s.r.o.

    Prague, Prague, 150 06, Czechia

  • Azienda Ospedale Università di Padova

    Padova, Padua, 35128, Italy

  • Barrow Neurological Institute

    Phoenix, Arizona, 85013, United States

  • Boro Neurology

    Hopewell, New Jersey, 08525, United States

  • Boston Clinical Trials

    Boston, Massachusetts, 02131, United States

  • CenExel Rocky Mountain Clinical Research

    Englewood, Colorado, 80113, United States

  • Central Texas Neurology Consultants

    Round Rock, Texas, 78681, United States

  • Centrum Zdrowia i Urody MAXXMED

    Lublin, Lublin Voivodeship, 20-080, Poland

  • David and Rhoda Chase Family Movement Disorders Center - Vernon

    Vernon, Connecticut, 06066, United States

  • Duke Neurology Morreene Road Clinic

    Durham, North Carolina, 27705, United States

  • ETG Neuroscience Sp. z o. o

    Warsaw, Masovian Voivodeship, 02-677, Poland

  • EvergreenHealth Research Department

    Kirkland, Washington, 98034, United States

  • Fakultní Nemocnice u sv. Anny v Brně

    Brno, South Moravian, 656 91, Czechia

  • Gill Neuroscience

    Houston, Texas, 77065, United States

  • Global Neurosciences Institute at Pennington

    Pennington, New Jersey, 08534, United States

  • Henrico Doctors Neurology Associates, LLC

    Richmond, Virginia, 23229, United States

  • Horizon Clinical Research Group

    Cypress, Texas, 77429, United States

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Universitari General de Catalunya

    Sant Cugat del Vallès, Barcelona, 08190, Spain

  • Hospital Universitari i Politècnic La Fe

    Valencia, Valenciana, Comunidad, 46026, Spain

  • Hospital Universitario Cruces

    Barakaldo, Biscay, 48903, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, Andalusia, 41013, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Houston Methodist Neurological Institute

    Houston, Texas, 77030, United States

  • Hôpital Gui de Chauliac

    Montpellier, Hérault, 34295, France

  • Hôpital Pierre Wertheimer

    Bron, Auvergne-Rhône-Alpes, 69500, France

  • Hôpital Pierre-Paul Riquet

    Toulouse, Haute-Garonne, 31059, France

  • Hôpital Roger Salengro

    Lille, Nord, 59037, France

  • Hôpitaux Universitaires Henri Mondor

    Créteil, Val-De-Marne, 94010, France

  • Inland Northwest Research

    Spokane, Washington, 99202, United States

  • Inova Fairfax Medical Campus

    Falls Church, Virginia, 22042, United States

  • Inova Neurology - Fairfax

    Fairfax, Virginia, 22031, United States

  • Inova Parkinson's and Movement Disorders Center - Alexandria

    Alexandria, Virginia, 22311, United States

  • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - San Raffaele Pisana

    Rome, 00163, Italy

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • King's College Hospital NHS Foundation Trust

    London, SE5 9RS, United Kingdom

  • Medical College of Wisconsin-Department of Neurology

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Monash Health

    Cheltenham, Victoria, VIC 3192, Australia

  • Muhammad Ali Parkinson Center

    Phoenix, Arizona, 85013, United States

  • N1 Research LLc

    Orlando, Florida, 32825, United States

  • Nemocnice Pardubického kraje, a.s. - Pardubická nemocnice

    Pardubičky, Pardubice, 530 03, Czechia

  • Neuro-Care Centrum Medyczne

    Katowice, Silesian Voivodeship, 40-001, Poland

  • Neurologia Śląska Centrum Medyczne

    Katowice, Silesian Voivodeship, 40-123, Poland

  • Neurologie Taláb Radomír Doc. MUDr., CSc

    Hradec Králové, 500 03, Czechia

  • Newcastle Upon Tyne Hospitals NHS Foundation Trust

    Newcastle upon Tyne, England, NE4 5PL, United Kingdom

  • Northern Care Alliance NHS Foundation Trust

    Bury, BL9 7TD, United Kingdom

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Parkinson's Disease Center of SWFL

    Port Charlotte, Florida, 33980, United States

  • Parkinson's Disease and Movement Disorders Center of Boca Raton

    Boca Raton, Florida, 33486, United States

  • Parkinson's Research Centers of America - Long Island

    Commack, New York, 11725, United States

  • Parkinson's Research Centers of America - Orange County

    Newport Beach, California, 92663, United States

  • Parkinson's Research Centers of America - Orange county

    Aliso Viejo, California, 92656, United States

  • Parkinson's Research Centers of America - Palo Alto

    Palo Alto, California, 94301, United States

  • Perron Institute for Neurological and Translational Science

    Nedlands, Western Australia, WA 6009, Australia

  • Policlínica Gipuzkoa

    San Sebastián, Gipuzkoa, 20014, Spain

  • Praglandia s.r.o.

    Prague, Prague, 150 00, Czechia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, QLD 4102, Australia

  • Quest Research Institute

    Farmington Hills, Michigan, 48334, United States

  • Raleigh Neurology Associates

    Raleigh, North Carolina, 27607, United States

  • Renstar Medical Research

    Ocala, Florida, 34471, United States

  • Riverhills Healthcare, Inc dba Riverhills Neuroscience

    Cincinnati, Ohio, 45212, United States

  • SFM Clinical Research, LLC

    Boca Raton, Florida, 33487, United States

  • San Raffaele Cassino

    Cassino, Frosinone, 03043, Italy

  • Southern Neurology

    Kogarah, New South Wales, NSW 2217, Australia

  • St Vincent's Hospital Sydney

    Darlinghurst, New South Wales, NSW 2010, Australia

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona, 85013, United States

  • Texas Movement Disorder Specialists, PLLC

    Georgetown, Texas, 78628, United States

  • The Alfred

    Melbourne, Victoria, VIC 3004, Australia

  • The Alliance Hispanic Alliance for Clinical and Translational Research

    Rio Piedras, 00935, Puerto Rico

  • The Kirklin Clinic of UAB Hospital

    Birmingham, Alabama, 35233, United States

  • The Movement Disorder Clinic of Oklahoma

    Tulsa, Oklahoma, 74136, United States

  • The Neurological Institute

    Charlotte, North Carolina, 28204, United States

  • The Ohio State University - Martha Morehouse Medical Plaza

    Columbus, Ohio, 43221, United States

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • USF Parkinson's Disease and Movement Disorders Center

    Tampa, Florida, 33613, United States

  • Universidad de Puerto Rico Recinto de Ciencias Médicas

    San Juan, 00936-5067, Puerto Rico

  • University Clinical Research-DeLand, LLC d/b/a Accel Research Sites - Brain & Spine Institute

    Port Orange, Florida, 32127, United States

  • University Hospitals Plymouth NHS Trust

    Plymouth, PL6 8BU, United Kingdom

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of Alabama at Birmingham ALS Clinic

    Birmingham, Alabama, 35294, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Kentucky, Dept of Neurology Kentucky Neuroscience Institute Research

    Lexington, Kentucky, 40536, United States

  • University of Michigan Dept. of Neurology

    Ann Arbor, Michigan, 48109, United States

  • University of Michigan Hospital - Michigan Clinical Research Unit (MCRU)

    Ann Arbor, Michigan, 48109, United States

  • Velocity Clinical Research

    Raleigh, North Carolina, 27607, United States

  • Veracity Neuroscience LLC

    Memphis, Tennessee, 38157, United States

  • Vseobecna Fakultni Nemocnice v Praze

    Prague, Prague, 128 08, Czechia

  • Vseobecna Fakultni Nemocnice v Praze

    Prague, 120 00, Czechia

  • Weill Cornell Medical College

    New York, New York, 10021, United States

  • Westmead Hospital-Department of Neurology

    Sydney, New South Wales, NSW 2145, Australia

  • Wielospecjalistyczna Poradnia Lekarska Synapsis

    Katowice, Silesian Voivodeship, 40-123, Poland

Conditions

Explore the condition pages connected to this study.