Skin test could reveal Parkinson's progression

NCT ID NCT06621602

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses a small skin sample to measure levels of a protein linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 participants for 18 months to see if changes in the protein match disease progression. The goal is to develop a simple biomarker test to track the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to a simple skin test to monitor Parkinson's disease progression and help develop new treatments.

What could go wrong

This is an early observational study with only 100 participants, so results may not apply to everyone. The protein levels in skin may not reliably reflect brain changes.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Parkinson disease REM sleep behavior disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Atlanta NeuroScience Institute ANI

    Atlanta, Georgia, 30327, United States

  • Aventura Neurologic Associates, LLC

    Aventura, Florida, 33180, United States

  • Boston Neuro Research Center

    Boston, Massachusetts, 02747, United States

  • CND Life Sciences

    Scottsdale, Arizona, 85258, United States

  • Cedars Sinai

    Los Angeles, California, 90048, United States

  • MedStar Montgomery Medical Center

    Olney, Maryland, 20832, United States

  • Movement Disorders Center of Arizona

    Scottsdale, Arizona, 85258, United States

  • Neurology Multidisciplinary Clinic at Norton Healthcare

    Louisville, Kentucky, 40241, United States

  • Parkinson's Disease and Movement Disorders Center - Boca Raton

    Boca Raton, Florida, 33486, United States

  • Parkinson's Disease and Movement Disorders Center at KUMC

    Kansas City, Kansas, 66160, United States

  • Parkinson's Research Centers of America - Long Island

    Commack, New York, 11725, United States

  • Parkinson's Research Centers of America - Orange County

    Aliso Viejo, California, 92656, United States

  • Parkinson's Research Centers of America - Palo Alto

    Palo Alto, California, 94301, United States

  • The Medical University of South Carolina

    Charleston, South Carolina, 29403, United States

  • UT Health San Antonio

    San Antonio, Texas, 78229, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Rochester

    Rochester, New York, 14618, United States

  • Veracity Neuroscience LLC

    Memphis, Tennessee, 38157, United States