PARKINSON DISEASE

This study tested a device that uses focused ultrasound to create a small burn in a brain area linked to tremors. It included 26 people with Parkinson's disease whose tremors did not improve with medication. The goal was to see if the procedure is safe and reduces shaking.

This pilot study explores whether the timing and amount of protein in meals can help preserve muscle health and improve sleep in people with Parkinson disease. Participants follow either a protein redistribution diet (low protein during the day, high protein at dinner) or a prote…

This phase 2 trial tested whether infusions of stem cells (HB-adMSCs) from healthy donors could help people with Parkinson's disease. 60 participants received either the stem cells or a placebo (salt water) to see if the treatment improved movement and daily living. The study is …

This Phase 2 study tested whether low doses of nilotinib, a drug already approved for leukemia, are safe and affect brain markers in 75 people with Parkinson's disease. Participants took either a placebo or one of two low doses of nilotinib daily for 12 months. The goal was to se…

This study tested a drug called BIIB122 in 650 people with early-stage Parkinson's disease. The goal was to see if the drug could slow down the worsening of symptoms like movement problems and daily living tasks. Participants took either BIIB122 or a placebo daily for up to 3 yea…

This study tested a drug called lenrispodun in 79 people with Parkinson's disease who experience 'wearing off' symptoms and involuntary movements. Participants took the drug or a placebo once daily alongside their usual treatment. The goal was to see if lenrispodun could improve …

This study tested a new drug called vutiglabridin in 99 people with early Parkinson's disease. Participants took either the drug or a placebo daily for 24 weeks. The goal was to see if the drug is safe and can help control symptoms like movement problems. The study is complete, b…

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain via a pump for years. The goal is to monitor safety during long-term use and manage a gradual, individualized dose reduction until the treatment stops, switching to an alternative…

This early study tested a new approach for people with advanced Parkinson's disease who have severe motor fluctuations despite optimized oral medication. A pump placed in the abdomen delivered a special form of dopamine (A-dopamine) directly into the brain's fluid spaces, aiming …

This phase 2 study tested whether a person's own stem cells (called HB-adMSCs) could help control Parkinson's disease symptoms. Twenty-four adults with early to moderate Parkinson's received either stem cell infusions or a placebo over 32 weeks, and were followed for safety. The …

This study tested whether giving amantadine early in Parkinson's disease, before patients develop involuntary movements from their main medication (L-DOPA), could prevent or delay those movements. Researchers enrolled 210 people with early-stage Parkinson's who had been on L-DOPA…

This study tested a device called ExAblate that uses focused ultrasound to create a tiny lesion in the brain area causing Parkinson's motor problems. 36 participants were randomly assigned to receive the real treatment or a sham (fake) procedure. The goal was to see if the treatm…

This small study tested whether a device that uses focused ultrasound (sound waves) can safely improve movement problems in people with Parkinson's disease. Six participants who already had one side treated received the second side. The goal was to check safety and see if symptom…

This pilot study tested whether a focused ultrasound device could temporarily open the blood-brain barrier to deliver the drug Cerezyme into the brains of 4 people with Parkinson's disease. The main goal was to see if the procedure was safe and could successfully get the drug int…

This study tested whether taking citalopram for 26 months could slow the buildup of harmful amyloid plaques in the brain area responsible for visual thinking in people with Parkinson's disease. Fifty-eight participants aged 65 and older were randomly assigned to receive either ci…

This early-stage trial tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The vaccine is designed to train the immune system to attack abnormal clumps of a protein called alpha-synuclein, which are linked to these brain disorders. The …

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling, shopping, or eating. 117 people with Parkinson's and moderate-to-severe impulse control problems took either pimavanse…

This phase 2 trial tested whether metformin, a widely used diabetes medication, could improve symptoms in people with Parkinson's disease. Sixty participants who were already taking levodopa received either metformin or a placebo. Researchers measured changes in movement and dail…

This early-stage trial tested a drug called allopregnanolone in 10 people with Parkinson's disease. The goal was to see if a larger study is possible and if the drug is safe. Participants received weekly infusions for 12 weeks, and researchers looked for signs of improvement on b…

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow down Parkinson's disease. 372 adults with early Parkinson's took either the drug or a placebo for 9 months. The goal was to see if the drug could reduce both movement and non-m…

This study tested whether directional deep brain stimulation (DBS) can improve walking and balance problems in people with Parkinson's disease. Nineteen patients who already had DBS electrodes implanted took part. Researchers compared different stimulation settings to see which h…

This completed study tested whether two diabetes medications, sitagliptin and dapagliflozin, are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 participants took either a drug or a placebo daily for a short time. The goal w…

This early-phase study tested whether injecting human neural stem cells into specific brain areas is safe for people with Parkinson's disease. Twelve participants received the cell therapy at one of three dose levels. The main goal was to check for side effects, while also lookin…

This Phase 2 trial tested an experimental capsule called TJ0113 in 149 people with early-stage Parkinson's disease. Participants took either 200 mg, 400 mg, or a placebo daily for 12 weeks. The main goal was to see if the drug improved motor symptoms, measured by a standard ratin…

This study tested the safety and effectiveness of tavapadon, an experimental drug, in 992 people with Parkinson's disease over 58 weeks. Participants took flexible doses of the medication to see how well it controlled symptoms and what side effects occurred. The goal was to under…

This study tested a new way to place deep brain stimulation electrodes in people with Parkinson's disease. Instead of the usual method that requires patients to be awake for testing, the new approach uses MRI scans and a computer model to guide the surgery under general anesthesi…

This early-phase study tested whether a drug called Leukine (sargramostim) is safe for people with Parkinson's disease when taken for 36 months. Seven participants received a weight-based dose 5 days a week. Researchers monitored side effects, immune system changes, and motor sym…

This study tested two different brain areas for deep brain stimulation (like a pacemaker for the brain) in 27 people with tremor-dominant Parkinson's disease. The goal was to see which target—the posterior subthalamic area or the subthalamic nucleus—better reduces shaking. Each p…

This completed Phase 2 trial tested whether lixisenatide, a daily injection already used for diabetes, could slow the worsening of motor symptoms in 156 people with early Parkinson's disease. Participants received either the drug or a placebo for 12 months, alongside their usual …

This Phase 3 trial tested whether tavapadon, a daily pill, can improve movement and daily activities in people with early Parkinson's disease. Over 300 participants took either tavapadon or a placebo for 27 weeks. The study measured changes in motor function and daily living skil…

This study tested an experimental drug called IkT-148009 (risvodetinib) in 137 people with early, untreated Parkinson's disease. Participants took one of three doses or a placebo daily for 12 weeks. The goal was to check safety and see if the drug improves movement and daily livi…

This early-phase study tested the safety and tolerability of a new drug called PDM608 in 64 healthy adults. The goal was to see if the drug is safe enough to study further in people with Parkinson's disease. Participants received either PDM608 or a placebo, and researchers monito…

This study tested a new type of deep brain stimulation (DBS) that adapts in real time to help people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet. Standard DBS delivers constant stimulation, but this adaptive system uses brain sig…

This study tested whether rivastigmine, a drug already used for memory problems in Parkinson's, can reduce falls. 600 people with Parkinson's who had fallen in the past year took either the drug or a placebo patch for 12 months and recorded their falls. The goal was to see if the…

This completed Phase 3 trial tested whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can slow the progression of early Parkinson's disease. 410 people with early-stage Parkinson's took either the supplement or a placebo for 52 weeks. Researchers meas…

This study tested whether digital analysis of voice recordings can help doctors tell apart Parkinson's disease and multiple system atrophy, two brain disorders with similar early symptoms. Researchers recorded the voices of 28 people (patients with each condition and healthy cont…

This study tested whether artificial intelligence (AI) can help diagnose Parkinson's disease by analyzing brain scans called DaTSCAN SPECT. Researchers used machine learning to tell the difference between healthy people, those with Parkinson's, and those with similar conditions. …

This study developed and tested a self-questionnaire called the 3PDQ to help diagnose pain that is directly caused by Parkinson's disease, rather than from other causes. Researchers enrolled 227 Parkinson's patients with chronic pain and compared their questionnaire answers with …

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested a new blood test that uses a microfluidic chip to detect Alzheimer's disease. Researchers collected blood and urine samples from 150 people, including those with Alzheimer's, other brain diseases, and healthy volunteers. The goal was to see if the test could acc…

This study tested a new PET scan tracer, [18F] LBT-999, to see if it can distinguish Parkinson's disease from essential tremor as well as the current standard SPECT scan. Researchers compared the two imaging methods in 152 patients. If the PET scan works equally well, it could of…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether group drumming classes could improve quality of life and motor skills in people with Parkinson's or Huntington's disease. Eighteen participants took drum lessons twice a week for 12 weeks. Researchers measured changes in anxiety, depression, hand functio…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. It also looks at how exercise affects thinking skills and related biological markers. …

This study tested whether a software tool (Guide XT) can replace the long, exhausting process of choosing the best stimulation settings for Parkinson's patients with brain implants. Twenty-six patients took part. The goal was to see if the software was at least as good as the sta…

This study tested whether doing both physical and mental exercises together, delivered through remote sessions, can improve quality of life and balance in people with Parkinson's disease. Thirty participants completed the program, which focused on tasks like walking while solving…

This pilot study tested whether a specially adapted mindfulness program is feasible for people with Parkinson's disease. The program included shorter meditations, more movement, and extra breaks. Researchers enrolled 20 patients to see if they could complete the program and if it…

This pilot study tested a wrist-worn device called Felix that delivers gentle electrical stimulation to suppress hand tremors. The device uses artificial intelligence to adjust stimulation in real time based on each person's tremor. 38 adults with essential tremor or Parkinson's …

This study tested whether adding action observation therapy (watching videos of movements) to standard physical therapy could help people with Parkinson's disease who experience freezing of gait. 42 participants aged 50-80 completed the trial. The goal was to see if this approach…

This small pilot study tested whether using inflatable cuffs on the legs (blood flow restriction) during low-intensity stepping exercise could safely improve mobility and quality of life in people with advanced Parkinson's disease. Three participants exercised twice a week for 8 …

This study tested two types of deep brain stimulation in 20 people with Parkinson's disease: standard omnidirectional stimulation and a newer directional steering method. The goal was to see if steering the stimulation could better control motor symptoms like muscle rigidity. Par…

This study tested a spinal stimulation device to help people with advanced Parkinson's disease walk better and improve balance. Two participants received an implanted stimulator and underwent rehabilitation for 3 to 5 months. The goal was to see if the approach is safe and could …

This study looked at whether a structured 8-week mindfulness-based stress reduction (MBSR) program is practical for people with Parkinson's disease. Thirty-one participants were enrolled to see how many could complete the program, including weekly group sessions and a full medita…

This study tested a wearable system (a haptic module and insole device) designed to detect freezing of gait in people with Parkinson's disease and then trigger cues to help them start walking again. The study enrolled 31 participants and aimed to validate the device's performance…

This study tested whether doing fast bodyweight exercises at home, supervised remotely, can reduce bradykinesia (slowness of movement) in people with Parkinson's disease. Forty-six participants aged 50 and older were assigned to either high-speed or usual-speed exercises for 12 w…

This study tested a smartphone-based wearable system that gives real-time feedback to people with Parkinson's disease while they do balance exercises at home. Nine participants aged 50 to 75 with mild to moderate Parkinson's used the system or followed a paper-based routine. The …

This study tested whether training with rhythmic sounds (like a beat) could help people with Parkinson's disease move their arms better. 38 participants did arm exercises with or without the sounds for 21 days. Those who used rhythmic sounds showed lasting improvements in hand de…

This study tested whether people with Parkinson's disease can safely use a brain stimulation device (tDCS) at home. Six participants aged 40 to 70 used the device for 20 minutes daily over a week, with video call support. The goal was to see if it's practical and safe, and to che…

This pilot study tested a new way of using deep brain stimulation (DBS) to help Parkinson's disease patients who experience freezing of gait—a sudden inability to move their feet—even with standard DBS. Ten participants received stimulation at different frequencies in two brain a…

This study looked at vision problems in people with Parkinson's disease compared to healthy individuals. Researchers tested eye and visual skills, then had some Parkinson's patients do simple eye exercises. The goal was to see if these exercises could slow vision decline or reduc…

This study tested whether two drugs, oxycodone (a strong painkiller) and levodopa (a Parkinson's medication), can reduce nerve pain caused by Parkinson's disease. 67 adults with Parkinson's and chronic nerve pain took one of the drugs or a placebo for 8 weeks, alongside their usu…

This study tested if a one-time, non-invasive foot stimulation treatment (called AMPS) could temporarily improve movement, balance, and heart function in people with Parkinson's disease. 40 participants with mild to moderate Parkinson's were included. The goal was to see if this …

This study tested a program that teaches people with early-stage Parkinson's disease how to add more physical activity into their daily lives. 89 participants either received the program or were placed on a waiting list. Researchers measured their daily moderate-to-vigorous activ…

This study tested whether a self-administered, mild electrical brain stimulation technique (transcranial direct current stimulation) can improve walking in people with Parkinson's disease. Twenty-four participants used the device at home while performing walking tasks, both alone…

This study looked at whether combining exercise training with a ketone ester drink can improve muscle endurance and heart fitness in people with Parkinson's disease. Nineteen participants completed a cycling program while taking the supplement. Researchers measured changes in how…

This study tested an 8-session stress management program for people recently diagnosed with Parkinson's disease and their caregivers. The program teaches relaxation techniques, healthy habits, and ways to change negative thinking. Researchers wanted to see if the program was prac…

This Phase 2 trial tested an experimental drug called UCB0022 in 207 people with advanced Parkinson's disease. The goal was to see if adding UCB0022 to standard treatment could reduce the daily hours spent in the 'OFF' state, when Parkinson's symptoms return. Participants took ei…

This study tested two rhythm-based walking exercises in 74 people with mild-to-moderate Parkinson's disease. Participants walked to music or while singing for 12 weeks. Researchers measured walking speed and brain activity to see which method worked better.

This study tested whether specially designed virtual reality exercises could improve arm and hand function in people with Parkinson's disease. 44 participants completed the program, which focused on matching arm positions. The goal was to see if this approach could help with ever…

This study tested whether adding arm and hand exercises to leg exercises during high-intensity circuit training helps people with Parkinson's disease more than leg exercises alone. Sixty-four participants completed eight exercise classes. Researchers measured changes in reaction …

This study tested whether adding a device that applies pressure to specific points on the feet (automated mechanical peripheral stimulation, or AMPS) to a regular exercise program could improve heart health and movement in people with Parkinson's disease. Forty participants were …

This study tested whether people with Parkinson's disease can use augmented reality glasses (Cue X) to do daily rehabilitation exercises at home. 30 participants used the glasses for 6 weeks, guided remotely by a physiotherapist. The goal was to see if this technology is practica…

This study tested a modified Mediterranean-ketogenic diet in 52 people with Parkinson's disease to see if it is safe for their gut microbiome. The diet limits carbs and emphasizes healthy fats and lean proteins. Researchers measured gut inflammation and other markers to check for…

This study tested whether bright light therapy can help with sleepiness and mood problems in people with Parkinson's disease. 69 participants were randomly assigned to receive bright light, a placebo light, or an active control. The goal was to see if the therapy reduces daytime …

This study tested whether a split-belt treadmill (where each leg moves at a different speed) can reduce freezing of gait during turning in people with Parkinson's disease. 26 participants completed a 4-week training program that included practicing everyday turning scenarios. The…

This study tested a new type of deep brain stimulation (DBS) called adaptive DBS (aDBS) in 25 people with Parkinson's disease. Unlike standard continuous DBS, aDBS adjusts stimulation in real time based on brain signals. The goal was to see if aDBS uses less total electrical ener…

This small study tested whether a spinal cord stimulator (a device that sends mild electrical pulses to the spinal cord) could reduce freezing of gait in people with Parkinson's disease. Ten participants who did not get relief from standard treatments received the implant. Resear…

This study tested a wearable device called PDVibe2 that delivers vibration therapy to improve walking and balance in people with Parkinson's disease. 12 participants with mild to moderate Parkinson's used the device while researchers measured their gait and movement. The goal was…

This study tested whether infusing tiny bubbles of oxyhydrogen gas could help people with Parkinsonism. 35 adults received the infusion alongside their usual care. Researchers measured changes in disease severity, thinking ability, and quality of life. The goal was to see if this…

This small study tested whether donepezil (Aricept), a drug that boosts the brain chemical acetylcholine, could improve walking and balance in 6 people with Parkinson's disease. Researchers also looked at how brain shrinkage in a key area relates to gait problems. The goal is to …

This small pilot study tested whether a weekly hula dance program is practical and enjoyable for people with Parkinson's disease. Fifteen participants took hula classes for three months, and researchers measured how many completed the program and assessed changes in movement and …

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants used either bright-white or dim-red light boxes at different times of day. The goal was to find the most effective dose to ease slee…

This early study tested a new drug called Lu AF28996 in 57 people with Parkinson's disease. The main goal was to see if the drug is safe and how the body handles it. Researchers measured side effects and drug levels in the blood. This is a first step to see if the drug might help…

This study tested whether a non-invasive magnetic stimulation of the spinal cord, combined with treadmill walking, could improve gait problems in people with Parkinson's disease. 76 participants with moderate Parkinson's and walking difficulties received either real or sham stimu…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve balance and walking in people with Parkinson's disease. 21 participants received both low- and high-frequency stimulation in a double-blind …

This study tested whether a 6-month in-home cycling program, combined with social engagement and coaching calls, can improve daily function and sleep in people with Parkinson disease. Fourteen participants cycled at home with staff support and received follow-up calls. The goal w…

This study looked at whether inner ear problems cause balance issues in Parkinson's disease and if a headset that stimulates the inner ear can help. 72 people with Parkinson's took part. They received a 20-minute stimulation session while researchers measured freezing of gait and…

This completed phase 2 trial tested whether a non-invasive magnetic coil placed on the upper back could improve walking in 42 Parkinson's patients who already have deep brain stimulation but still have gait problems. Participants received either active or placebo stimulation in a…

This Phase 2 trial tested whether insulin sprayed into the nose is safe for people with Parkinson's disease. Over 3 weeks, 31 participants received either intranasal insulin or a placebo. Researchers monitored safety events like low blood sugar and weight loss, and also looked at…

This study tested whether low-intensity focused ultrasound (LIFUP) can safely improve motor symptoms like tremor and stiffness in people with Parkinson's disease. 31 participants received either real or sham ultrasound to a specific brain area. The goal was to see if this non-inv…

This study tested a drug called suvecaltamide for people with Parkinson's disease who still have moderate to severe tremor despite taking other medications. Over 17 weeks, 169 participants received either the drug or a placebo, with doses adjusted for best effect. The goal was to…

This study tested whether weekly improvisational dance classes could improve thinking and daily function in people with Parkinson's disease. Twenty participants were randomly assigned to either take the 12-week dance class or continue their usual routine. Researchers measured cha…

This study tested whether a virtual reality treadmill (C-Mill) could improve walking and balance in people with Parkinson's disease better than standard physical therapy. Twenty patients aged 60-80 with mild to moderate Parkinson's were randomly assigned to either VR treadmill re…

This study tested whether adding Baduanjin, a gentle mind-body exercise, to standard physical therapy helps older adults with Parkinson's disease. 27 people in a nursing home took part, doing either standard therapy alone or standard therapy plus Baduanjin for 12 weeks. Researche…

This study looked at whether nutritional supplements, specifically N-acetyl cysteine (NAC) given orally and intravenously, could support brain function in people with Parkinson's disease. The researchers measured dopamine activity and markers of inflammation in the brain using sp…

This study looked at whether a gentle electrical stimulation of the vagus nerve through the ear, combined with physical therapy, can help people with Parkinson's disease move better and feel better. Twenty-five adults with Parkinson's who could walk without help took part. The go…

This study tested whether Erickson hypnosis can reduce chronic pain in people with Parkinson's disease. 33 participants were split into two groups: one received weekly hypnosis sessions for 2 months, the other got usual care. The main goal was to see if pain intensity changed fro…

This trial tested a wearable device called STAT-ON, which automatically records when Parkinson's patients have trouble moving ('Off' periods) and when they move well ('On' periods). The goal was to see if giving this detailed information to doctors helps them adjust medication mo…

This study tested whether playing a special video game that involves movement could improve walking and balance in people with Parkinson's disease. Twenty-five patients with stubborn gait problems played either the active game or a placebo game without movement. Researchers measu…

This completed study tested a smart electric vehicle designed to detect and improve walking problems in 120 people aged 60-85 with Parkinson's disease or dementia. The vehicle uses artificial intelligence to monitor gait, provide feedback, and assist with balance. The main goal w…

This study tested whether online dance classes or online therapeutic exercises, both with music, could improve quality of life for people with Parkinson's disease. Forty adults with mild to moderate Parkinson's took part. The goal was to see if these social, online programs could…

This study tested whether a culturally tailored program using a fitness tracker and a peer partner could help older Latino adults with Parkinson's disease become more active. Ten participants wore activity monitors, watched educational videos, met weekly with a peer online, and j…

This completed study tested whether low-frequency magnetic stimulation (rTMS) on the cerebellum could help people with Parkinson's disease. Forty participants received either real or sham stimulation daily for two weeks. Researchers measured changes in movement, brain activity, a…

This study tested whether a mild electrical current applied to the front of the brain (tACS) could improve speech and thinking in people with Parkinson's disease. 28 participants received either real or fake (sham) stimulation for 20 minutes daily over two weeks. Researchers meas…

This study tested whether adding video-based games to standard exercise could improve arm movement, balance, and quality of life in people with Parkinson's disease. Thirty participants aged 50-80 with mild to moderate Parkinson's and a stooped posture took part. One group did sta…

This study tested whether using immersive virtual reality or computer-based brain training could improve thinking and memory in people with Parkinson's or Huntington's disease who have mild cognitive problems. Sixty-four participants were randomly assigned to one of three groups:…

This study tested whether music therapy can prevent hospital-related confusion (delirium) in people with Parkinson's disease or Lewy body dementia. 30 hospitalized adults took part, receiving either music therapy sessions, self-directed music listening, or standard care. Research…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This study looked at how partnered tango dancing affects brain activity in people with Parkinson's disease. Researchers measured brain signals during leg movements before and after dance training. The goal was to see if dance could improve motor control by changing how brain regi…

This study tested whether a walker that provides visual and auditory cues (lights and sounds) can help people with Parkinson's disease who experience freezing of gait. Thirty participants walked on a 7-meter path with and without the cueing walker. The goal was to see if the cues…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This pilot study tested whether an 8-week mindfulness meditation program could reduce embarrassment from tremor in 21 people with Parkinson's disease. Participants wore a smartwatch to track tremor during daily life. The study aims to see if this approach is worth testing in a la…

This small study tested an experimental drug called SAGE-718 in 18 people with Parkinson's disease who also had mild thinking and memory problems. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it might help with thinking, mood, an…

This study tested a drug called SAGE-718 in 86 people with Parkinson's disease who have mild memory or thinking problems. Participants took either the drug or a placebo pill for a set time. The main goal was to see if SAGE-718 could improve processing speed, measured by a symbol-…

This study tested whether a gait re-education program using a sequential square treadmill (Tapiz Fisior) could help people with mild-to-moderate Parkinson's disease walk better and reduce fall risk. Fifty-two participants were randomly assigned to either the treadmill program plu…

This study tested whether a high-intensity functional training (HIFT) program could improve both thinking and physical abilities in people with Parkinson's disease. Fifteen participants with early-stage Parkinson's completed the program, which included strength and coordination e…

This study tested whether learning Argentine tango can improve thinking, mood, and movement in people with mild-to-moderate Parkinson's disease. Forty-five participants took either tango lessons or did general walking and stretching twice a week for six weeks. Researchers measure…

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study looked at 69 people with Parkinson's disease to see if sleep quality is linked to thinking skills and disease severity. Participants completed tests of sleep, memory, attention, and movement in one session. The goal is to better understand how these factors relate, whi…

This completed study from France examined perfectionism, depression, and anxiety in 59 people with Parkinson's disease. Participants filled out standard questionnaires about perfectionism, mood, and anxiety. The goal was to better understand how these psychological factors relate…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study used body-worn sensors to track movement in 132 people with early, untreated Parkinson's disease over 12 months. The goal was to see if digital measurements could accurately measure disease progression and match standard clinical assessments. The findings may help deve…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This study looked at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants received either an alcoholic drink or a non-alcoholic placebo on separate days. Researchers measured tremor changes using a motion sensor and clini…

This study looked at 733 people with Parkinson's disease to see if certain genetic variations in the AQP4 gene are linked to worse motor, cognitive, and sleep symptoms. Participants provided blood samples, wore sleep monitors, and completed online tests. The goal is to better und…

This study looked at 158 people with Parkinson's disease to see if different thinking patterns are linked to differences in brain structure and activity. Researchers grouped participants based on their cognitive profiles and compared brain scans and EEG readings. The goal was to …

This study looked at why people with Parkinson's disease often gain weight after deep brain stimulation of the subthalamic nucleus. Researchers measured energy use and metabolism in 20 patients before and after treatment. The goal was to understand if weight gain is due to change…

This study aims to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers will first study patients' health profiles and balance, then test a simple exercise program called OTAGO to see if it prevents falls. The goal …

This study looked at 70 Parkinson's patients to see if their personality, coping style, and social support could predict how much their quality of life improved after six months of continuous apomorphine infusion. Researchers measured personality traits before treatment and compa…

This study tested whether using a special scanner (O-ARM) in the operating room is as good as standard imaging done before surgery for placing brain electrodes in Parkinson's patients. 24 people took part, and researchers measured how accurately the electrodes were placed. The go…

This study looked at whether it's possible and safe for people with early-stage Parkinson's disease to stop their medication for one week while being monitored with brain scans and wearable sensors. Twenty participants were followed to see how their symptoms and brain activity ch…

This study looked at whether a special workshop about Parkinson's medications could change how patients think about their drugs. 24 people with Parkinson's took part. The goal was to see if learning more about their medicines helps them manage treatment better.

This study tested whether wearable sensors can reliably measure movement problems in people with Parkinson's disease. Fifty participants wore sensors while performing tasks like finger tapping and walking. The goal was to see if these sensors could provide objective data to help …

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…

This study used MRI scans to look at brain activity in people with Parkinson's disease while they moved their arms and legs. The goal was to understand how the brain changes affect motor symptoms. 40 people took part, including those with Parkinson's and healthy volunteers.

This study looked at pain thresholds in people with multiple system atrophy (MSA) and Parkinson's disease. Researchers tested how levodopa, a common Parkinson's drug, affects pain perception. The goal is to better understand the causes of pain in MSA and improve future treatment.

This study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…

This study looked at how a gentle electrical current applied to the scalp (tDCS) affects brain signals in 20 people with Parkinson's disease. Researchers measured brain activity during a reaching task to see exactly how tDCS changes movement-related signals. The goal was to bette…

This completed study tested whether low-intensity focused ultrasound aimed at a brain area called the zona incerta (ZI) can reduce tremors in 20 people with Parkinson's disease. Researchers compared this approach to the standard target (Vim) and used brain scans to understand how…

This study looked at whether simple eye-tracking tests can help measure how Parkinson's disease changes over time. About 300 people with early-stage Parkinson's had their eye movements recorded and compared with standard clinical exams. The goal was to see if eye tests could dete…

This study tested whether a daily probiotic supplement called Bacillus subtilis can change certain gut bacteria and blood markers in people with Parkinson's disease. Twenty-six participants took either the probiotic or a placebo for a period. The goal was to see if the supplement…

This study tested how accurately a robot system called Neurolocate helps place electrodes in the brain during deep brain stimulation surgery. It involved 18 adults with Parkinson's disease, dystonia, or tremor. The goal was to see if the robot could improve precision, reduce surg…

This completed study looked at how common muscle loss (sarcopenia) is in people with Parkinson's disease. Researchers compared 43 Parkinson's patients (early and moderate stages) with 22 healthy adults. They used ultrasound to measure thigh muscle thickness, handgrip strength, an…

This study looked at back tissue thickness, trunk flexibility, and hand dexterity in people with Parkinson's disease. Researchers compared 80 participants aged 50-80 with mild to moderate Parkinson's to healthy individuals. They used ultrasound and physical tests to measure diffe…

This study looked at how forced and voluntary exercise change brain signals and thinking skills in 25 people with Parkinson's disease who have a brain pacemaker (DBS). Participants did one session of each exercise type while off their usual medications and DBS. The goal was to fi…

This study looked at whether a special balance training called protective step training can help people with Parkinson's disease react better to trips or pushes. Twelve participants completed the training, which involved standing and walking while being gently disturbed to test t…

This study adapted the Parkinson's Disease Quality of Life 7 (PDQoL7) questionnaire into Turkish and tested its reliability and validity with 129 Parkinson's patients. Participants completed the PDQoL7 along with other standard questionnaires. The goal was to ensure the Turkish v…

This completed study looked at 129 people with Parkinson's disease to understand what factors are linked to fatigue. Researchers measured fatigue, sleep, mood, and physical function using questionnaires and a walking test. The goal was to identify which aspects of Parkinson's mos…

This study looked at why Hispanic people with Parkinson's disease may have more thinking and memory problems. Researchers checked 40 participants for heart-related risks like diabetes, high blood pressure, and obesity. The goal was to understand how these factors might contribute…

This study looked at how different types of exercise change brain activity in 15 people with Parkinson's disease who have a brain pacemaker (deep brain stimulation). Participants cycled while off their medication, and researchers measured brain signals and movement skills. The go…

This study tested a new questionnaire called the NF-scale, designed to measure sudden mood and thinking changes (neuropsychiatric fluctuations) that can occur in Parkinson disease. 130 French-speaking participants with Parkinson disease and motor fluctuations filled out the quest…

This study looked at how people with Parkinson's disease who have trouble swallowing and their caregivers work together during meals. Researchers filmed 22 patient-caregiver pairs and interviewed them to understand the verbal and non-verbal strategies used to make eating safer an…

This study followed 29 people with Parkinson's disease, along with healthy volunteers and people with a similar condition, to better understand speech and movement issues that don't respond to standard Parkinson's medication. Researchers used brain scans, breathing tests, and wal…

This study used a special brain imaging technique called HD-DOT to see how deep brain stimulation (DBS) changes brain network activity in 49 people with Parkinson's disease. Researchers compared scans with DBS turned on and off, while participants did motor and cognitive tests. T…

This study looked at whether practicing a fine motor task while doing a second task (like counting lights) helps people with Parkinson's disease remember the motor skill better. Eighty participants, including people with Parkinson's and healthy controls, practiced a finger moveme…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study followed 83 people with Parkinson's disease and healthy volunteers to see if daily walking patterns measured at home can track how the disease progresses. Participants wore special insoles for 10 days at a time to record their gait. The goal was to find simple, real-wo…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…

This study investigated why humans swing their arms during walking, a common but poorly understood movement. Researchers had 25 participants, including healthy individuals and those with conditions like stroke or Parkinson's disease, walk on a force-sensing treadmill. They measur…

This study used virtual reality to recreate situations that cause freezing of gait in people with Parkinson's disease who have a deep brain stimulator. Fifteen participants walked through a virtual home and grocery store while their brain signals were recorded. The goal was to be…

This study tested whether ultrasound imaging can help understand and suppress tremors in people with Parkinson's disease or essential tremor. Researchers used ultrasound to watch hand muscles during grasping motions and developed models to predict tremor. They then used mild elec…

This study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…

This completed study examined how a specific serotonin receptor (5-HT4) is expressed in the brains of people with mild to moderate Parkinson's disease compared to healthy older adults. Researchers used PET scans and a special tracer to measure receptor levels, alongside cognitive…

This study tested new ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease. Instead of constant stimulation, researchers tried intermittent patterns to see if they could control movement symptoms while causing fewer thinking or memory problems. Sixte…

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, such as family history, loss of smell, blood pressure drops, or a sleep disorder. Participants underwent brain scans, spinal taps, and other tests over several y…

This study looked at how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Fifteen patients who already had a DBS device implanted performed movement and impulse control tasks while their brain activity was measured using a special light-base…

This study tested whether artificial intelligence (AI) could better predict fall risk in people with Parkinson's disease by analyzing walking tests under single and dual-task conditions. Thirty participants completed balance and mobility assessments while being recorded on video.…

This completed online study looked at whether natural environments like parks, gardens, and lakesides can improve mood and cognition in people with and without Parkinson's disease. 97 participants filled out surveys about their connection to nature, depressive symptoms, sleep, an…

This completed study examined gut bacteria in 15 people with inflammatory bowel disease (IBD) or Parkinson's disease, comparing them to healthy individuals. Researchers analyzed stool and blood samples to see if bacteria from the gut move into the bloodstream. The goal was to und…

This study looked at whether giving feedback after a delay, instead of immediately, helps people with Parkinson's disease learn better. Forty participants completed a computer task where they got either instant or 25-minute-delayed feedback. The goal was to see if delayed feedbac…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This completed study used eye-tracking to explore how the brain adapts movements in people with dystonia, essential tremor, or Parkinson disease. Researchers measured eye movements before and after a task to look for signs of cerebellar dysfunction. The study included 14 particip…

This study tested whether a short questionnaire about falls, called the Dresden Falls Questionnaire, works well for Turkish-speaking people with Parkinson's disease. Researchers asked 64 patients to fill out the questionnaire along with other surveys during rehab sessions. The go…