PARKINSON DISEASE

This early-phase study tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The goal was to see if the vaccine is safe and helps the body make antibodies against a harmful protein linked to these brain diseases. The study focused on safe…

This study tested a new way to treat movement problems in Parkinson's disease using focused sound waves (ExAblate) to target a small area in the brain. 36 people with Parkinson's took part, and some received the real treatment while others had a fake (sham) procedure. The goal wa…

This early-phase study tested whether a drug called Leukine (Sargramostim) is safe for people with Parkinson's disease when taken for 36 months. Seven participants received a weight-based dose 5 days a week, with 2-day breaks. Researchers monitored side effects, immune system cha…

This study tested whether amantadine, given early in Parkinson's disease, can prevent or delay the involuntary movements (dyskinesia) caused by the standard drug L-DOPA. About 210 people with early-stage Parkinson's who had been on L-DOPA for less than a year took either amantadi…

This study tested whether a drug called rivastigmine, already used for memory problems in Parkinson's, can also prevent falls. 600 people with Parkinson's who had fallen in the past year received either the drug or a placebo patch for 12 months. The goal was to see if the drug co…

This early-phase study tested whether injecting human neural stem cells into the brain is safe for people with Parkinson's disease. Twelve participants received the cell therapy at different doses. The main goal was to check for side effects, not to cure the disease, so ongoing P…

This study tested whether a person's own stem cells (called HB-adMSCs) could help control Parkinson's disease symptoms. 24 adults with early to moderate Parkinson's received either stem cells or a placebo over 32 weeks. The main goal was to see if the treatment improved daily liv…

This study tested whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can slow the progression of early Parkinson's disease. Over 400 people with early-stage Parkinson's took either the supplement or a placebo for one year. Researchers measured changes …

This study tested a new way to perform deep brain stimulation (DBS) for Parkinson's disease. The new method puts patients to sleep and uses brain scans to guide the surgery, avoiding the need for awake testing. The trial involved 128 people with advanced Parkinson's and compared …

This study tested two different spots in the brain for deep brain stimulation (DBS) to see which one better controls tremors in people with Parkinson's disease. 27 participants received stimulation in both the posterior subthalamic area (PSA) and the subthalamic nucleus (STN) in …

This study tested a new way to deliver dopamine directly into the brain using a pump for people with advanced Parkinson's disease who have severe movement ups and downs. Twelve participants received either the brain pump or their usual oral medications for one month, then switche…

This study tested a new drug called TJ0113 in 149 people with early-stage Parkinson's disease. The goal was to see if it improves motor symptoms like movement and coordination compared to a placebo. The trial was double-blind, meaning neither patients nor doctors knew who got the…

This small pilot study tested a drug called allopregnanolone in 10 people with Parkinson's disease. The goal was to see if a larger study is possible, if the drug is safe, and if it shows any signs of improving symptoms. Participants received weekly infusions for 12 weeks, and ev…

This study tested whether a single type of donated stem cell (HB-adMSCs) could help people with Parkinson's disease. 60 adults aged 45-80 received either the stem cells or a placebo. The goal was to see if the treatment improved movement and daily living skills, and to check for …

This study tested whether taking citalopram for 26 months could slow the buildup of harmful amyloid plaques in the part of the brain that controls vision and thinking in people with Parkinson's disease. The trial involved 58 older adults with mild to moderate Parkinson's. Researc…

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow the worsening of Parkinson's disease. 372 adults with early Parkinson's took either the drug or a placebo for 9 months. Researchers measured changes in movement and non-movemen…

This study looked at whether two types of diabetes medications (DPP4 and SGLT2 inhibitors) are safe and helpful for people with Parkinson's disease or Lewy body dementia who also have mild diabetes or pre-diabetes. 18 participants took the drugs for 4 weeks, and researchers measu…

This small study tested the safety of using focused ultrasound to treat movement problems in people with Parkinson's disease. Six participants who had already received one side of the treatment got the other side treated. The goal was to see if it was safe and if it could improve…

This study tested the long-term safety and effectiveness of tavapadon, an experimental drug, in nearly 1,000 people with Parkinson's disease over 58 weeks. Participants took flexible doses of the drug, and researchers monitored side effects, movement symptoms, and quality of life…

This study tested a new way to treat hand tremors in people with Parkinson's disease. It used focused ultrasound waves to target a small area in the brain. Ten adults with tremors that did not improve with medication took part. The goal was to see if the treatment is safe and if …

This study tested whether metformin, a drug used for diabetes, can help people with Parkinson's disease. 60 adults with Parkinson's who were already taking levodopa took part. The goal was to see if metformin could improve movement and daily function, and to check changes in bloo…

This study tested whether lixisenatide, a drug used for diabetes, could slow the worsening of movement problems in people with early Parkinson's disease. 156 participants received either the drug or a placebo alongside their usual Parkinson's medications. The goal was to see if l…

This study tested a new 'adaptive' deep brain stimulation (aDBS) system for people with Parkinson's disease. The device is designed to sense the brain's activity and automatically adjust its electrical stimulation, aiming to provide symptom control while using less battery power …

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures how well a person can move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or amput…

This study tested whether a new type of PET scan can tell the difference between Parkinson's disease and essential tremor as well as the current standard SPECT scan. 152 adults with either condition received both scans. The goal was to see if the newer method is at least as accur…

This study created and tested a simple questionnaire called the 3PDQ to help doctors identify pain that is directly caused by Parkinson's disease, rather than other conditions. Researchers worked with 227 French-speaking Parkinson's patients who had chronic pain. The goal is to m…

This study tested whether adding a foot massage-like device (automated mechanical peripheral stimulation) to regular exercise could improve movement and heart health in people with Parkinson's disease. 40 participants were split into two groups: one got the real device plus exerc…

This study tested a video-based exercise program for the arms and hands in 30 people with Parkinson's disease. Participants played interactive games designed to improve movement, balance, and quality of life. The goal was to see if this fun, low-cost approach could help with ever…

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants received either bright-white or dim-red light at different times of day. The goal was to find a safe, effective way to ease sleep tr…

This study tested a gait re-education program using a special square treadmill (Tapiz Fisior) in 52 people with mild to moderate Parkinson's disease. Participants were split into two groups: one received the treadmill program plus standard physical therapy, and the other received…

This study tested whether people with Parkinson's disease can use augmented reality glasses (called Cue X) to do daily rehab exercises at home. 30 participants used the glasses for 6 weeks, guided remotely by a physiotherapist. The goal was to see if this approach is practical an…

This study tested a non-invasive magnetic stimulation of the spinal cord to improve walking in 42 people with Parkinson's disease who already have a deep brain stimulator. The goal was to see if this treatment could help with gait problems that don't respond to standard therapies…

This study tested whether low-frequency magnetic stimulation (rTMS) on the cerebellum could improve symptoms in people with Parkinson's disease. Forty adults aged 40–80 with mild to moderate Parkinson's took part. Researchers measured changes in movement, brain scans, and blood m…

This study tested whether specially designed virtual reality exercises could improve arm and hand function in people with Parkinson's disease. 44 participants completed the program. The goal was to see if these exercises help with coordination and daily tasks.

This study tested whether adding action observation therapy (watching videos of movements) to standard physical therapy helps people with Parkinson's disease who experience freezing of gait. 42 participants aged 50-80 with mild to moderate Parkinson's took part. The goal was to s…

This small study tested whether people with Parkinson's disease can safely use a brain-stimulation device called tDCS at home. Six participants aged 40 to 70 used the device for 20 minutes each day for a week, with video call support. The main goal was to see if it was practical …

This study tested whether music therapy can prevent hospital-acquired delirium (sudden confusion) in patients with Parkinson's disease or Lewy body dementia. Thirty hospitalized adults were assigned to music therapy sessions, self-directed music listening, or standard care. Resea…

This study tested an 8-week stress management and resiliency program for people recently diagnosed with Parkinson's disease and their caregivers. The program teaches relaxation skills, healthy habits, and ways to cope with stress. Researchers measured whether the program was prac…

This study tested a new drug called IkT-148009 in 137 people with early Parkinson's disease who were not yet on other treatments. Participants took one of three doses or a placebo daily for 12 weeks. The main goals were to check safety and see if the drug helps with movement and …

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve balance and walking in people with Parkinson's disease. Twenty-one participants received both low- and high-frequency stimulation in a doubl…

This study tested a safe, self-administered brain stimulation technique called transcranial direct current stimulation (tDCS) in 24 people with Parkinson's disease. The goal was to see if it could improve walking, both normally and while doing another task at the same time. Parti…

This study tested if walking on a split-belt treadmill (where each leg moves at a different speed) for four weeks could reduce freezing of gait during turns in people with Parkinson's. 26 participants did either treadmill training with turning practice or treadmill training with …

This study looked at whether a non-invasive device that gently stimulates a nerve in the ear (vagus nerve) can boost the benefits of physical therapy for people with Parkinson's disease. 25 participants completed the study. The goal was to see if this combination could improve mo…

This study looked at whether donepezil (Aricept), a drug that increases a brain chemical called acetylcholine, can improve walking and balance in people with Parkinson's disease. Six adults with Parkinson's and walking problems took the drug for 12 weeks. Researchers measured cha…

This study tested whether pimavanserin, a drug already approved for Parkinson's psychosis, can reduce impulse control disorders like compulsive gambling or eating in people with Parkinson's disease. 117 adults aged 35-75 with moderate symptoms took part. The goal was to see if th…

This study looked at whether nutritional supplements, especially N-acetyl cysteine (NAC), could support brain function in people with Parkinson's disease. 51 adults with early-stage Parkinson's were randomly assigned to receive NAC (orally and intravenously), standard care, or ot…

This study tested two rhythm-based walking exercises—walking to music and walking while singing—in 74 people with mild to moderate Parkinson's disease. Over 12 weeks, participants trained using these rhythms to see if they could improve their walking speed and brain activity. The…

This study looked at whether Ericksonian hypnosis can reduce chronic pain in people with Parkinson's disease. 33 adults with Parkinson's and ongoing pain were split into two groups: one received hypnosis sessions for 2 months, the other continued with their usual care. The main g…

This study looked at vision problems in people with Parkinson's disease and tested simple eye exercises to see if they could help. Researchers compared 160 people with and without Parkinson's to understand their vision issues. Then, some Parkinson's patients did eye movement or p…

This study tested whether a special video game program could help people with Parkinson's disease who have trouble walking and balancing. 25 patients took part in a randomized trial. The program aimed to improve their movement and quality of life through fun, interactive exercise…

This study tested a new way to use deep brain stimulation (DBS) to help with walking and balance problems in people with Parkinson's disease. The researchers used a special electrode that can shape the electrical field more precisely. Nineteen patients who were already getting DB…

This study tested whether a walker that provides visual and auditory cues can improve walking in people with Parkinson's disease who experience freezing of gait. Thirty participants walked with and without the cueing walker, and their gait was measured. The goal was to see if the…

This study tested an experimental drug called SAGE-718 to see if it could improve thinking and memory in people with Parkinson's disease who have mild cognitive impairment. 86 participants took either the drug or a placebo. The main goal was to measure changes in processing speed…

This study tested whether infusing tiny bubbles of oxyhydrogen gas could help people with Parkinsonism. Researchers measured changes in disease severity, thinking ability, and quality of life in 35 adults aged 18-70. The treatment was given as a complementary therapy alongside st…

This study tested if a gentle, non-invasive brain stimulation called tACS could help people with Parkinson's disease think more clearly and speak more easily. 28 adults received either real or fake (placebo) stimulation for 20 minutes daily over two weeks. Researchers measured ch…

This study tested whether bright light therapy can improve daytime sleepiness and mood in people with Parkinson's disease. 69 participants were randomly assigned to receive bright light, a placebo light, or an active control. The goal was to see if this simple, non-drug approach …

This small pilot study tested whether a mindfulness meditation program could reduce embarrassment from tremor in people with Parkinson's disease. Twenty-one participants were split into two groups: one received meditation training, the other did not. Researchers used questionnair…

This study tested whether a nasal spray of insulin is safe and might help with thinking, mood, and movement in people with Parkinson's disease. 31 participants used the spray for 3 weeks. The main goal was to check for side effects like low blood sugar or weight loss, while also …

This study tested whether combining a non-invasive spinal stimulation technique (repetitive transspinal magnetic stimulation) with treadmill walking can improve gait problems in people with Parkinson's disease. 76 participants with moderate Parkinson's and walking difficulties we…

This study tested a program where older Latino adults with Parkinson's disease paired up with a peer partner for 8 weeks. They used activity trackers, watched educational videos, and attended online exercise classes together. The goal was to see if this approach was practical and…

This study tested a new, non-invasive technique called Low-Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can improve motor symptoms in people with Parkinson's disease. 31 participants received the ultrasound while their brain activity was monitored with an MRI. The …

This study tested a wearable device called PDVibe2 that delivers gentle vibrations to improve walking and balance in people with Parkinson's disease. Twelve adults with Parkinson's who had trouble walking, such as freezing or shuffling, tried the device. Researchers measured chan…

This study tested whether a special education program could help people with early-stage Parkinson's disease become more physically active in their daily lives. 89 participants either received the program or were placed on a waiting list. The program focused on changing habits to…

This study looked at whether a modified Mediterranean-ketogenic diet is safe for the gut microbiome in people with Parkinson's disease. Fifty-two adults with mild to moderate Parkinson's tried the diet for 8 weeks. Researchers measured gut inflammation and other gut health marker…

This study tested whether a weekly hula dance program is practical and helpful for people with Parkinson's disease. Fifteen participants took hula classes for three months, and researchers measured their balance, movement, and quality of life before and after. The goal was to see…

This study tested whether spinal cord stimulation (SCS) can help Parkinson's patients who experience freezing of gait (sudden inability to walk) that doesn't improve with medication. Ten adults with Parkinson's received SCS to see if it safely reduces freezing episodes and improv…

This study tested two drugs, oxycodone (a strong painkiller) and levodopa (a Parkinson's medication), against a placebo to see if they could reduce nerve pain caused by Parkinson's disease. 67 people with Parkinson's and chronic nerve pain took one of the three treatments for 8 w…

This study looked at whether combining exercise training with a ketone ester supplement can improve muscle endurance and heart fitness in people with Parkinson's disease. Nineteen participants completed cycling tests before and after the program. The goal was to see if this combi…

This small pilot study tested a new way of using deep brain stimulation in 10 people with Parkinson's disease who still had freezing of gait despite standard treatment. The researchers stimulated two brain areas together instead of one, hoping to reduce walking problems. The stud…

This study looked at whether Argentine tango classes can improve thinking skills, mood, and movement in people with mild-to-moderate Parkinson's disease. Forty-five participants took part in the program, which combined music, movement, and social interaction. Researchers measured…

This study tested whether adding Baduanjin, a gentle mind-body exercise, to standard physical therapy helps older adults with Parkinson's disease. 27 people in a nursing home took part, doing either standard therapy or standard therapy plus Baduanjin for 12 weeks. Researchers mea…

This study tested a drug called suvecaltamide in 169 adults with Parkinson's disease whose hand or arm tremors were still bothersome despite their usual medications. The goal was to see if the drug could reduce tremor severity and improve daily activities like eating and dressing…

This study looked at whether a 6-month in-home cycling program, combined with social support and health coaching, could improve daily activities and sleep for people with Parkinson's disease. Fourteen participants used a stationary bike at home and received guidance from a health…

This study tested a new type of deep brain stimulation (DBS) for people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet while walking. Unlike standard DBS, which delivers constant stimulation, this adaptive system uses brain signals …

This study tested a 12-week exercise program set to music for 108 adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. Participants were randomly assigned to the music exercise group or a waitlist. The goal was to see if the program improved h…

This study looked at whether improvisational dance classes can improve thinking and daily life for people with Parkinson's disease. Twenty participants were randomly assigned to either take weekly dance classes for 12 weeks or continue their normal routine. Researchers measured c…

This study tested if a single session of automated foot stimulation could temporarily improve movement, balance, and heart function in 40 people with mild to moderate Parkinson's disease. Participants received a non-invasive foot massage-like therapy, and researchers measured cha…

This study tested a new medicine called SAGE-718 in 18 people with Parkinson's disease who also have mild memory or thinking problems. The main goal was to see if the drug is safe and tolerable, and to check if it helps with thinking, mood, and movement. The study was completed a…

This study tested whether online dance classes or online therapeutic exercises could improve quality of life for people with Parkinson's disease. Forty participants were split into two groups, both including music. The goal was to see if these social telerehabilitation programs h…

This study tested whether smart electric vehicles can detect and improve walking problems in people with neurodegenerative diseases like Parkinson's or dementia. 120 participants aged 60-85 with mild to moderate walking issues took part. The goal was to see if these vehicles coul…

This study tested a new drug called tavapadon in 304 people with early Parkinson's disease. The goal was to see if it improves movement and daily living skills compared to a placebo over 27 weeks. Participants took flexible doses of the drug or a dummy pill, and researchers measu…

This early-stage study tested a new drug called Lu AF28996 in 57 people with Parkinson's disease. The main goal was to see if the drug is safe and how the body processes it. Researchers measured side effects and drug levels in the blood. This is a first step to see if the drug mi…

This study tested whether adding arm and hand exercises to leg exercises during high-intensity circuit training helps people with Parkinson's disease more than leg exercises alone. Sixty-four participants completed 8 exercise classes. Researchers measured reaction time, balance, …

This study tested whether doing exercises that combine movement and thinking tasks at home (via video calls) can improve quality of life, balance, and walking in people with Parkinson's disease. Thirty participants completed the program. The goal was to see if this approach works…

This study looked at whether group drum classes could help people with Parkinson's or Huntington's disease feel better and move easier. Eighteen adults aged 18-89 took drum lessons twice a week for 12 weeks. Researchers checked their hand movement, mood, and overall well-being be…

This study tested an experimental drug called UCB0022 in 207 people with advanced Parkinson's disease. The goal was to see if adding UCB0022 to standard treatment (including levodopa) could reduce the daily hours when symptoms return, known as 'OFF' time. Participants were random…

This study tested whether training with rhythmic music (like a steady beat) can help people with Parkinson's disease move their arms better. 38 participants did arm exercises with or without the music for 21 days. Those who trained with the beat showed improved hand speed and dex…

This study tested whether cognitive rehabilitation using immersive virtual reality or computer-based brain games could improve thinking skills in people with mild cognitive impairment from Parkinson's or Huntington's disease. 64 participants were randomly assigned to one of three…

This study compared two types of rehabilitation for people with Parkinson's disease: a standard physical therapy program and a program using a virtual reality treadmill. Researchers worked with 20 patients to see which approach better improved walking, balance, and quality of lif…

This study looked at 300 people with early-stage Parkinson's disease to see if simple eye-tracking tests could measure how the disease changes over time. Researchers compared eye movement patterns with standard clinical exams. The goal was to find a faster, easier way to track Pa…

This study tested how accurately a robot called Neuromate, using its Neurolocate system, can target specific brain areas during deep brain stimulation surgery. Researchers compared the robot's aimed point to the actual point reached in 18 patients with Parkinson's disease, dyston…

This study tested a new questionnaire (the NF-scale) designed to measure sudden mood and thinking changes that can happen in Parkinson's disease. Researchers worked with 130 French-speaking adults who have Parkinson's and experience motor fluctuations. The goal was to confirm tha…

This study looked at whether spending time in nature improves mood and thinking for people with and without Parkinson's disease. About 97 adults aged 40 and older completed online surveys about their connection to nature, mood, sleep, and quality of life. The goal was to understa…

This study looked at why people swing their arms when they walk, especially in people with conditions like multiple sclerosis, stroke, or Parkinson's disease. Researchers had 25 participants walk on a special treadmill to measure how arm movement relates to body motion. The goal …

This study tested whether a mobile app that gives visual feedback and motivational messages can help older adults (60+) with conditions like COPD, heart failure, or Parkinson's become more active during their hospital stay and for three months after going home. Researchers tracke…

This study looked at how common muscle loss and weakness are in people with Parkinson's disease. Researchers compared 43 Parkinson's patients (early and moderate stages) with 22 healthy adults of similar age. They measured muscle thickness with ultrasound, grip strength, and how …

This small pilot study tested whether a focused ultrasound technique could safely open the blood-brain barrier in 4 Parkinson's patients to deliver the drug Cerezyme. The main goal was to see if the barrier opened on MRI scans and to check for side effects. The study did not aim …

This study looked at why Hispanic people with Parkinson's disease may have more thinking and memory problems. Researchers compared 40 participants from California and North Carolina, checking their heart health risks like diabetes, high blood pressure, and obesity. The goal was t…

This study followed 29 people with Parkinson's disease to learn more about speech and movement issues that don't respond to standard medication. Researchers used brain scans (fMRI) and other tests to compare patients with healthy volunteers and people with a similar condition. Th…

This study looked at whether a probiotic called Bacillus subtilis can change certain markers in the gut and blood of people with Parkinson's disease. 26 participants took the probiotic or a placebo to see how it affected their gut bacteria, blood fats, inflammation, and other hea…

This completed study used PET scans to watch brain activity while people performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to learn how the frontal lobe works during thinking and how certain drugs might aff…

This early-stage study tested a new drug called PDM608 in 64 healthy adults to see if it is safe and how the body processes it. The goal was to check for side effects and measure drug levels, not to treat Parkinson's disease yet. Results will help decide if further testing in pat…

This study looked at brain activity when people with and without Parkinson's disease move their legs. Researchers also tested whether two types of partnered dance change brain activity. About 87 adults aged 40-70 took part. The goal was to learn more, not to treat the disease.

This study looked at how a single session of exercise changes brain activity in 25 people with Parkinson's disease who have a deep brain stimulation (DBS) device. Participants did both fast and voluntary cycling while off their usual medications and DBS. The goal was to understan…

This study watched and interviewed 22 pairs of people with Parkinson's disease (who have trouble swallowing) and their caregivers during meals. The goal was to describe the verbal and non-verbal strategies used to help the person eat safely and with pleasure. No new treatments we…

This study looked at whether inner ear problems contribute to poor balance in people with Parkinson's disease. Researchers tested a small device that stimulates the inner ear to see if it could improve balance and walking. The study involved 72 participants with Parkinson's and u…

This study looked at 15 people with Parkinson's disease who have a deep brain stimulation device. Researchers used a special brain imaging technique to measure changes in brain blood flow while participants did a hand movement task and an impulse control task, both with the stimu…

This study looked at whether measuring how people with Parkinson's disease walk at home can help track how their condition changes over time. Researchers used special insoles to record walking data from 83 participants over 10-day periods. The goal was to see if these home-based …

This study used MRI scans to look at brain activity in people with Parkinson's disease while they moved their arms and legs. The goal was to understand how the brain changes cause movement symptoms. 40 adults took part, including some without Parkinson's for comparison.

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, like family history or loss of smell. Participants underwent tests such as brain scans, blood draws, and spinal taps, and were followed for several years. The go…

This study aimed to learn more about why people have tremors by observing brain activity and movement in 85 adults with tremor conditions like Parkinson's disease or essential tremor, as well as healthy volunteers. Participants underwent tests such as MRI scans, brain wave record…

This study aimed to find genes and environmental factors that raise the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including those with Parkinson's, related brain diseases, and healthy volunteers. No treatment was g…

This study looked at whether a special workshop about Parkinson's medications could change how patients think about their drugs. 24 people with Parkinson's took part. The goal was to see if learning more about their medicines could improve how they manage them.

This study aimed to translate a short, 7-question survey called PDQoL7 into Turkish and check if it works well for people with Parkinson's disease. Researchers tested it on 129 Turkish-speaking Parkinson's patients to see if the results were reliable and accurate. The goal is to …

This study looked at how people with dystonia, essential tremor, or Parkinson's disease adapt their eye movements compared to healthy volunteers. Researchers measured changes in eye movement speed and accuracy before and after a task. The goal was to learn more about how the cere…

This study looked at whether it's possible and safe for people with early-stage Parkinson's disease to stop their medication for one week while being monitored at home. Researchers used wearable motion sensors and special brain scans to measure changes in movement and brain activ…

This study used a special brain imaging technique called HD-DOT to understand how deep brain stimulation (DBS) affects brain networks in people with Parkinson's disease. The goal was to learn why DBS helps movement but can also cause mood or thinking side effects. The study invol…

This study tested a wearable device called the Parkinson Holter (STAT-ON) that automatically tracks movement ups and downs in people with moderate to severe Parkinson's disease. The goal was to see if giving doctors detailed, objective data from the device helps them adjust medic…

This study aims to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers worked with 11 seniors to test their balance and walking using special tools and a simple exercise program. The goal is to reduce falls and mak…

This study looked at how a gentle electrical current applied to the scalp (tDCS) affects brain signals in 20 people with Parkinson's disease. Researchers measured brain activity during a reaching task to see which signals improve movement. The goal was to learn more about how tDC…

This study looked at 24 people with Parkinson's disease who needed brain surgery to place electrodes. It compared using a special scanner in the operating room versus the usual method of scanning before surgery. The goal was to see which method places the electrodes more accurate…

This study looked at how two common treatments for low blood pressure upon standing—a medication called midodrine and an abdominal compression binder—affect heart health markers. Researchers measured things like pulse wave velocity and central blood pressure in 31 adults with aut…

This study looked at why people with Parkinson's disease often feel very tired. Researchers measured fatigue, mood, sleep, and physical function in 129 adults with Parkinson's. The goal was to find out which factors are most linked to fatigue, helping doctors better understand an…

This study tested whether using low-intensity focused ultrasound on a brain area called the zona incerta (ZI) can reduce tremors in people with Parkinson's disease. Twenty participants completed the study, which compared this new target to the standard target. The goal was to und…

This study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease, Parkinson's disease, or a family history of these conditions, against healthy volunteers. Researchers aimed to detect early brain changes linked to glucocerebrosidase gene mutatio…

This study involved 15 people with Parkinson's disease who had a deep brain stimulator (DBS) implanted. They walked through a virtual reality environment designed to trigger freezing of gait while their brain signals were recorded. The goal was to better understand what happens i…

This study tested whether wearable sensors can reliably measure movement issues in people with Parkinson's disease. 50 participants wore sensors while performing standard motor tasks. The goal was to see if these sensors could provide objective data to help monitor the disease.

This study aims to adapt the Dresden Falls Questionnaire (DREFAQ) for Turkish-speaking people with Parkinson's disease. Researchers will check if the Turkish version is accurate and reliable by comparing it to other fall and quality-of-life scales. 64 participants will answer que…

This study tested new ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease. The goal was to see if intermittent stimulation patterns could control movement symptoms as well as standard continuous stimulation, but with fewer effects on thinking and me…

This study looked at how Parkinson's disease affects walking and the ability to react to balance challenges. Researchers tested a type of training called protective step training in 12 people with Parkinson's. The goal was to see if this training could quickly improve their balan…

This study looked at a specific serotonin receptor (5-HT4) in the brains of people with mild to moderate Parkinson's disease compared to healthy volunteers. Using PET scans, researchers measured receptor levels and checked how they relate to movement, thinking, and mood symptoms.…

This study used brain imaging to track changes in people with Parkinson disease over up to 9 years. Researchers compared brain scans of people with definite or possible Parkinson to healthy volunteers. The goal was to better understand why dopamine-producing brain cells stop work…

This study tested whether artificial intelligence (AI) could better predict fall risk in people with Parkinson's disease by analyzing walking tests that involve thinking at the same time (dual-tasking). Thirty participants completed balance and stepping tests while being recorded…

This study looked at whether people with Parkinson's disease learn better when feedback on a test is delayed by 25 minutes instead of given right away. Researchers think delayed feedback may work through brain pathways not affected by Parkinson's. 40 participants completed a mult…

This study looked at the gut bacteria of 15 people with inflammatory bowel disease (IBD) or Parkinson's disease and compared them to healthy individuals. Researchers collected stool and blood samples to see which bacteria were present and whether bacteria were leaking from the gu…

This study tested whether a special watch called the Personal KinetiGraph (PKG) can accurately measure movement problems in people with Parkinson's disease. Researchers compared the watch's readings to standard medical tests and video recordings in 19 volunteers, including both p…

This study tested whether ultrasound imaging can detect and measure hand tremors in people with Parkinson's disease or essential tremor. Researchers also explored using mild electrical stimulation to suppress tremors during grasping tasks. The goal was to gather data to design be…

This study looked at 80 people (ages 55-80) to see how Parkinson's disease changes the thickness of a back tissue called the thoracolumbar fascia, along with trunk flexibility and hand dexterity. Researchers compared Parkinson's patients to healthy volunteers using ultrasound, mo…

This study looked at how different types of exercise change brain activity in people with Parkinson's disease who have a deep brain stimulator. Fifteen participants cycled while their brain signals were recorded. The goal was to understand why exercise can improve movement, which…

This study aimed to understand how to help people with Parkinson's disease better remember and retain practiced motor skills, like those used on a tablet or smartphone. Researchers compared two training methods—practicing a single task versus practicing while doing a second task—…