PARKINSON DISEASE

This study tested a new 'adaptive' brain stimulation system for Parkinson's disease patients who experience freezing of gait—sudden, temporary inability to walk. The device monitors brain signals and movement, then automatically adjusts stimulation levels in real-time instead of …

This study tested a new daily pill called IkT-148009 in people recently diagnosed with Parkinson's disease who were not yet taking other Parkinson's medications. Over 12 weeks, researchers compared three different doses of the drug to a placebo (a pill with no medicine) to see if…

This study tested whether a drug called deferiprone could slow the progression of Parkinson's disease. The drug works by removing excess iron from the brain, which researchers believe may contribute to the disease. The trial involved 372 adults with early-stage Parkinson's who we…

This study tested whether injections of a patient's own banked stem cells could help control the symptoms of Parkinson's disease. It was a small, Phase 2 trial where 24 participants with early to moderate Parkinson's were randomly assigned to receive either the stem cell treatmen…

This study compared two ways to perform deep brain stimulation surgery for advanced Parkinson's disease. Researchers tested whether surgery performed while patients are asleep under general anesthesia (without brain recordings during surgery) works as well as the traditional meth…

This study tested whether focused ultrasound could safely reduce Parkinson's disease motor symptoms like tremor and stiffness. Thirty-six participants with one-sided symptoms were randomly assigned to receive either the real ultrasound treatment or a sham procedure. Researchers c…

This small, early-stage study tested the safety of giving a drug called Leukine to people with Parkinson's disease for three years. Researchers wanted to see if this drug, which affects the immune system, was safe and tolerable at a lower dose schedule. They also checked if the t…

This study tested whether infusing a special solution containing tiny oxygen and hydrogen bubbles could help people with Parkinson's disease. It involved 35 patients and looked at whether the treatment could reduce disease severity, improve memory and thinking, and enhance qualit…

This study tested whether metformin, a common diabetes medication, could help control Parkinson's disease. It involved 60 patients already taking standard Parkinson's medication. Researchers measured changes in Parkinson's symptoms and blood markers to see if metformin provided a…

This study tested whether adding an experimental drug called UCB0022 to standard Parkinson's medication could help people with advanced disease. It involved 207 participants who still experienced daily periods where their medication wore off and symptoms returned. The main goal w…

This study tested whether using immersive virtual reality (VR) or computer-based brain training games could help slow down memory and thinking problems in people with Parkinson's or Huntington's disease. It compared these high-tech approaches to a more traditional music therapy p…

This small, early-stage study tested a new method to get medicine into the brain for Parkinson's disease. Researchers used focused ultrasound guided by an MRI to temporarily open the brain's protective barrier in four patients. They delivered a drug called Cerezyme three times to…

This study tested a new drug called tavapadon to see if it could help people with early Parkinson's disease. Over 300 participants took either the drug or a placebo for 27 weeks to measure improvements in movement and daily activities. The main goal was to see if tavapadon was sa…

This study tested if two modified ketogenic diets are safe for the gut health of people with Parkinson's disease. Fifty-two participants with Parkinson's tried each diet for eight weeks to see if they could get potential benefits without causing gut inflammation or imbalance. Res…

This small study tested whether focused ultrasound waves could safely treat Parkinson's disease movement problems without surgery. Six people who had already received one-sided brain treatment received the same treatment on the other side. Researchers measured whether this non-in…

This study tested the long-term safety and effectiveness of a medication called tavapadon for people with Parkinson's disease. Nearly 1,000 participants who had already completed earlier trials took flexible doses of the drug for 58 weeks. Researchers measured how well it control…

This small study tested a new training method to help people with Parkinson's disease improve their balance and prevent falls. Researchers had 12 participants practice recovering their balance from unexpected pushes while walking on a treadmill. The goal was to see if this specif…

This study tested whether taking the antidepressant citalopram for over two years could slow the buildup of harmful brain plaques linked to thinking problems in Parkinson's disease. Researchers compared citalopram to a placebo pill in 58 older Parkinson's patients without depress…

This study tested which of two specific brain areas is better for deep brain stimulation to control tremors in Parkinson's disease. Twenty-seven patients with tremor-dominant Parkinson's had electrodes implanted in both brain areas and tried each stimulation type in a blinded, ra…

This early-stage study tested a new drug called Lu AF28996 in people with Parkinson's disease who experience 'off' periods where their regular medications wear off. The main goals were to check if the drug was safe, how well people could tolerate it, and how their bodies processe…

This small, early-stage study tested the safety and immune response of an experimental vaccine called UB-312 in people with Parkinson's disease or multiple system atrophy. The goal is to see if the vaccine can safely train the body's immune system to target harmful proteins in th…

This study tested whether gentle, focused ultrasound pulses could improve movement symptoms like tremors and stiffness in people with Parkinson's disease. Researchers used MRI to guide the ultrasound to specific brain areas while measuring brain activity and movement performance.…

This study tested whether a wearable device that automatically tracks movement could help doctors better adjust medication for people with moderate Parkinson's disease. The device, worn during daily life, aimed to provide more accurate information than patient diaries or memory a…

This study tested whether infusions of donor stem cells could help control Parkinson's disease. Sixty participants with early to moderate Parkinson's received either six stem cell treatments or a placebo over 20 weeks. Researchers measured changes in movement, daily activities, a…

This study tested whether lixisenatide, a drug used for type 2 diabetes, could slow the worsening of movement problems in people with early Parkinson's disease. 156 participants received either the drug or a placebo as a daily injection for one year, in addition to their standard…

This large, completed study tested whether a daily supplement called nicotinamide riboside (a form of vitamin B3) could slow down the worsening of early Parkinson's disease. Over 400 people with recently diagnosed Parkinson's took either the supplement or a placebo pill for a ful…

This study investigated whether nutritional supplements with antioxidant properties could help support brain function in people with Parkinson's disease. Researchers tested an oral and intravenous supplement called N-acetyl cysteine (NAC) in 51 patients with early-stage Parkinson…

This study tested whether pimavanserin, a medication already approved for Parkinson's psychosis, could help control impulse control disorders in people with Parkinson's disease. These disorders can cause harmful compulsive behaviors like gambling, binge eating, or hypersexuality.…

This early-stage study tested whether injecting human neural stem cells into specific brain areas is safe for people with moderate to severe Parkinson's disease. Twelve participants received one of three different doses of the experimental cell therapy. The main goal was to check…

This study tested a new oral capsule called TJ0113 to see if it could help control the movement symptoms of early Parkinson's disease. About 150 people with early-stage Parkinson's took either TJ0113 or a placebo pill for 12 weeks. The main goal was to measure changes in movement…

This study tested new patterns of deep brain stimulation (DBS) for Parkinson's disease. Researchers wanted to see if using stimulation in short, timed bursts could control movement symptoms as well as the current method of constant stimulation, but with less impact on a patient's…

This study tested whether gently stimulating a specific part of the brain with magnets could help control Parkinson's disease symptoms. 40 participants with Parkinson's received either real or fake (sham) magnetic stimulation. Researchers measured changes in symptoms, brain activ…

This Mayo Clinic study explored whether two common diabetes medications could help control symptoms of Parkinson's disease and Lewy body dementia. The trial involved 18 patients who had these brain conditions along with mild diabetes or blood sugar issues. Researchers tested if t…

This study tested a new type of brain scan (called a PET scan) to see if it works as well as a standard scan (called a SPECT scan) for telling Parkinson's disease apart from essential tremor. It involved 152 adults with either condition. The goal was to see if the new scan could …

This study aimed to develop an artificial intelligence (AI) tool to better predict which people with Parkinson's disease are at high risk of falling. Researchers tested 30 participants with Parkinson's using standard balance tests and new 'dual-task' tests that combine walking wi…

This large UK trial tested whether a drug patch normally used for memory problems could prevent falls in people with Parkinson's disease. 600 participants who had experienced a fall in the past year were randomly assigned to wear either the real drug patch or a dummy patch for 12…

This small pilot study tested whether music therapy could prevent delirium (sudden confusion) in hospitalized patients with Parkinson's disease or Lewy body dementia. Thirty patients were randomly assigned to receive either personalized music therapy sessions, generic music playl…

This study tested a remote exercise program designed to help people with Parkinson's disease practice doing two things at once, like walking while thinking. Thirty participants tried either this dual-task training or standard exercises through video calls. Researchers measured if…

This small study looked at whether a combination of exercise training and a ketone ester supplement could help people with Parkinson's disease. Researchers wanted to see if this approach could improve muscle strength, endurance, and heart and lung fitness. Twenty participants wit…

This study tested whether a non-invasive magnetic device placed on the back could improve walking and balance in people with Parkinson's disease. It focused on patients whose walking problems persisted despite taking medication and having a deep brain stimulator implanted. Resear…

This study tested whether specially designed virtual reality exercises could improve arm and shoulder movement in people with Parkinson's disease. Forty-four participants with Parkinson's performed VR-based position-matching games aimed at their upper limbs. Researchers measured …

This small pilot study tested whether a non-invasive magnetic brain stimulation technique could improve balance and mobility in people with Parkinson's disease. Researchers compared different frequencies of stimulation in 21 participants to see effects on walking, reaching, and m…

This small pilot study tested whether adjusting the settings on an existing deep brain stimulator could help Parkinson's patients with a severe walking problem called freezing of gait. Ten patients who already had the brain implant tried three different stimulation patterns over …

This study tested the safety and side effects of an experimental drug called SAGE-718 in people with Parkinson's disease who have mild thinking and memory problems. Eighteen participants with early to moderate Parkinson's took the drug to see how well they tolerated it and whethe…

This study tested whether Argentine tango dancing could help people with mild to moderate Parkinson's disease. Researchers enrolled 45 participants to see if regular tango sessions could improve their thinking skills, mood, and physical movement. The goal was to understand if thi…

This study tested whether group drumming classes could help people with Parkinson's or Huntington's disease. Eighteen participants attended drum lessons twice a week for 12 weeks. Researchers measured changes in movement, mood, and overall well-being to see if the music therapy p…

This study tested whether online group dance classes or online therapeutic exercise classes work better for improving quality of life in people with Parkinson's disease. Forty participants with Parkinson's were randomly assigned to either dance or exercise groups that met online.…

This small study tested whether a non-invasive, focused ultrasound procedure could safely reduce severe hand and arm tremor in people with Parkinson's disease whose shaking doesn't respond well to medication. Ten participants had ultrasound waves precisely aimed at a small area i…

This study tested if adding 'action observation therapy'—watching videos of people performing movements—to standard physical therapy helps people with Parkinson's disease walk more easily. It involved 42 participants to see if this combined approach could reduce episodes of 'free…

This study tested whether adjusting the shape of electrical currents in deep brain stimulation could help Parkinson's patients with walking and balance problems. Researchers worked with 19 patients who already had brain implants to see if directing the stimulation more precisely …

This study tested whether a simple mobile device could help older hospital patients be more active. About 130 patients with conditions like COPD, heart failure, or frailty were randomly assigned to either use the device or not. The device gave visual feedback on their movement, a…

This small study explored whether a drug called donepezil (Aricept) could help improve walking and balance in people with Parkinson's disease. Researchers tested five participants to see if the drug's effect was linked to the size of a specific brain area involved in movement. Th…

This study tested whether combining a gentle, non-invasive electrical stimulation to the ear (targeting the vagus nerve) with supervised physical therapy could improve movement, balance, and daily life for people with Parkinson's disease. Twenty-five participants were randomly as…

This study tested whether a gentle, non-invasive brain stimulation technique could improve speech and thinking problems in people with Parkinson's disease. For two weeks, 28 participants received either real or fake stimulation to see if it helped with word-finding, memory, and s…

This study tested whether a nasal spray containing insulin is safe for people with Parkinson's disease. Over three weeks, 31 participants tried different doses or a placebo spray. Researchers mainly checked for safety issues like low blood sugar, but also looked for any changes i…

This study compared two types of rehabilitation for people with Parkinson's disease: a standard physical therapy program and a program using a virtual reality treadmill system. Twenty participants, aged 60-80, were split into two groups to see which method better improved their w…

This study tested whether a 6-month, at-home cycling program delivered via video call could help people with Parkinson's disease. It focused on reaching people in rural or underserved areas who have trouble accessing group exercise. Researchers wanted to see if regular, socially-…

This study tested whether a special education program could help people in the early stages of Parkinson's disease become more physically active in their daily lives. Researchers compared 89 patients who received the program to those on a waiting list, measuring their activity le…

This small study tested whether spinal cord stimulation could help Parkinson's patients with freezing of gait—sudden episodes where they can't move their feet forward, even with medication. Researchers implanted devices in 10 patients to see if electrical stimulation to the upper…

This study tested whether people with Parkinson's disease could use augmented reality glasses called Cue X to do their rehabilitation exercises at home. Thirty participants wore the glasses daily for six weeks, following a personalized program designed to help with walking, balan…

This study tested whether daily bright light therapy could help people with Parkinson's disease who struggle with severe daytime sleepiness. Researchers compared the light therapy against a fake light device and another inactive treatment in 69 participants. The main goal was to …

This study tested whether a video game-based rehabilitation program could help improve walking and balance in people with Parkinson's disease. Researchers worked with 25 patients who had movement problems that didn't respond well to standard medications. They measured changes in …

This study tested if a smart electric vehicle could help people with Parkinson's disease or dementia walk better. 120 participants aged 60-85 used the vehicle, which provided real-time feedback during a 45-minute walking training session. Researchers measured if this training imp…

This study aimed to find the most effective dose and timing of light therapy to improve sleep for people with Parkinson's disease. Researchers tested bright white light versus dim red light at different times of day with 203 participants over 16 weeks. The goal was to see which a…

This small pilot study explored whether a mindfulness meditation program could help reduce the embarrassment and impact of hand tremors in people with Parkinson's disease. Researchers monitored 21 participants, some practicing mindfulness and others receiving usual care, using sm…

This study tested whether a special treadmill with two independently moving belts could help reduce freezing episodes during turns for people with Parkinson's disease. Twenty-six participants with daily freezing episodes completed a four-week training program. Researchers measure…

This study tested a new approach to help people with Parkinson's disease who have trouble walking. Researchers combined a non-invasive magnetic stimulation treatment on the spine with treadmill training to see if it improved walking speed, balance, and reduced the risk of falls b…

This study tested whether a walker that provides visual and auditory cues could help people with Parkinson's disease walk better, especially those who experience sudden 'freezing' of their gait. Thirty participants walked with and without the special walker to see if it improved …

This study tested whether a 12-week exercise program called 'movement-to-music' (M2M) could improve fitness and well-being in adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. 108 participants were randomly assigned to either start the prog…

This study tested whether adding a special treadmill walking program to standard physical therapy could improve mobility and reduce fall risk in people with Parkinson's disease. Fifty-two participants with mild to moderate Parkinson's were randomly assigned to receive either stan…

This study tested whether adding Baduanjin, a gentle traditional Chinese exercise, to standard physical therapy could help people with Parkinson's disease. It involved 27 older adults living in a nursing home who were split into two groups: one received standard therapy, and the …

This study tested a small experimental device that delivers gentle vibration to see if it could safely help people with Parkinson's disease walk more easily. Twelve participants tried the device during short walking tests to measure if it reduced episodes of 'freezing' and improv…

This small pilot study explored whether a weekly hula dance class could help people with Parkinson's disease. Researchers created a special 3-month hula program designed for people with movement difficulties. The study aimed to see if this enjoyable activity could improve balance…

This study explored whether problems with the inner ear's balance system contribute to walking and balance difficulties in Parkinson's disease. Researchers tested whether a small device that stimulates the inner ear could help improve these symptoms. The study involved 72 partici…

This study tested whether adding video game exercises to standard physical therapy could help people with Parkinson's disease improve their arm movement, balance, and daily function. Thirty participants with Parkinson's were split into two groups: one received standard therapy, a…

This study tested whether Ericksonian hypnosis could help reduce chronic pain in people with Parkinson's disease. Thirty-three participants were divided into two groups: one received a two-month hypnosis program, while the other received standard care. Researchers measured change…

This study tested whether a new drug called suvecaltamide could help reduce moderate to severe tremor in people with Parkinson's disease whose shaking is not adequately controlled by their current medications. Over 17 weeks, 169 participants were randomly assigned to receive eith…

This study tested whether a 12-week program of weekly improvisational dance classes could help improve thinking skills, mood, and the ability to perform daily activities for people with Parkinson's disease. Twenty participants were randomly assigned to either start the dance clas…

This study tested whether an investigational drug called SAGE-718 could improve cognitive performance, specifically thinking speed, in people with Parkinson's disease who have mild thinking problems. 86 participants were randomly assigned to receive either the drug or a placebo f…

This small study tested whether a culturally adapted program could help older Latino adults with Parkinson's disease become more physically active. Ten participants used activity trackers, attended online exercise classes, and were paired with a peer partner for weekly virtual ch…

This study tested a new questionnaire designed to measure the mental and mood changes that happen in people with Parkinson's disease as their medication levels change. Researchers enrolled 130 French-speaking Parkinson's patients to see if the questionnaire is reliable and useful…

This study aimed to understand how Parkinson's disease affects the body's connective tissue and movement. Researchers compared 80 people with Parkinson's to healthy adults, using ultrasound scans to measure tissue thickness and simple movement tests. The goal was to gather knowle…

This study aimed to understand how Parkinson's disease affects speech, movement, and brain function over time. Researchers followed 29 Parkinson's patients and compared them to healthy volunteers using brain scans, speech assessments, and movement tests. The goal was to map brain…

This study explored whether delayed feedback helps people with Parkinson's disease learn better than immediate feedback. Researchers tested 40 participants with Parkinson's, having them take a multiple-choice test where feedback was given either right away or after a 25-minute de…

This study aimed to better understand Parkinson's disease by comparing the brains of people with the condition to healthy volunteers. Researchers used PET scans to measure levels of a specific brain receptor (5-HT4) in 40 participants. The goal was to see if changes in this recep…

This study aimed to find biological markers that could identify people at risk for Parkinson's disease long before movement symptoms appear. Researchers followed 89 healthy volunteers and people with specific risk factors (like family history or loss of smell) for up to 7.5 years…

This study aimed to understand how a common Parkinson's treatment called deep brain stimulation (DBS) changes how different parts of the brain communicate. Researchers used a new, cap-based brain scanner on 49 people with Parkinson's to see these brain network changes while the D…

This study used virtual reality to safely trigger freezing of gait episodes in 15 Parkinson's patients who have deep brain stimulators. While patients walked through VR environments, researchers recorded their brain signals to understand what happens in the brain during these fre…

This study aimed to understand how exercise helps people with Parkinson's disease. Researchers measured brain activity in 15 patients with deep brain stimulators while they performed two types of stationary cycling. The goal was to see if exercise changes the abnormal brain patte…

This study aimed to understand what factors are linked to the severe fatigue often experienced by people with Parkinson's disease. Researchers assessed 129 participants with Parkinson's, measuring their fatigue, sleep quality, mood, and physical abilities. The goal was to gather …

This study aimed to gather information to help design future tremor-control devices. Researchers tested a new method using ultrasound imaging to watch hand muscles in real-time and see how they move during a tremor. They combined this with gentle electrical stimulation to see if …

This early-stage study aimed to check if a new drug called PDM608 is safe for people and to see how the body handles it. The trial involved 64 healthy adults who received either the drug or a placebo as a single shot or weekly shots for a month. The main goal was to monitor for a…

This study aimed to understand why people swing their arms while walking and how this movement is connected to balance and energy use. Researchers observed 25 people, including healthy individuals and those with conditions like stroke, Parkinson's, or multiple sclerosis, while th…

This study tested whether special educational workshops could change how people with Parkinson's disease think and feel about their medications. Researchers compared 24 patients who attended a workshop about Parkinson's drugs to a control group who had general discussions. They m…

This study aimed to understand how the brain works during movement in people with Parkinson's disease. Researchers compared brain activity in people with and without Parkinson's while they performed foot-tapping tasks and participated in partnered dance classes. The goal was to l…

This study aimed to better understand how the brain controls movement and what causes tremors in conditions like Parkinson's disease and essential tremor. Researchers observed and measured brain activity in 85 participants, including people with tremor and healthy volunteers, usi…

This study aimed to understand the connection between Gaucher disease and Parkinson's disease by looking at how the brain works. Researchers used PET and MRI brain scans to compare people with these conditions, their family members, and healthy volunteers. The goal was to learn a…

This study aimed to understand how common muscle loss and weakness are in people with Parkinson's disease. Researchers compared 43 people with Parkinson's at different stages to 22 healthy individuals, measuring their muscle thickness, grip strength, and ability to stand up from …

This study measured brain activity in 25 Parkinson's patients while they exercised on stationary bikes. Researchers wanted to understand how different types of exercise affect brain function and thinking skills in people with Parkinson's. The goal was to gather information that c…

This study aimed to find better ways to measure how Parkinson's disease changes over time. Researchers tracked 83 people with Parkinson's and related conditions by having them wear special insoles that recorded their walking patterns at home for 10 days. They compared these walki…

This study tested a Turkish version of a questionnaire called the Johns Hopkins In-Room Independence Scale. Researchers gave the questionnaire to 100 adult volunteers with various conditions to see if it reliably measures how well a person can move and care for themselves in thei…

This online study aimed to understand if spending time in natural environments like parks or near water benefits mood, sleep, and thinking skills. Researchers surveyed 97 people, including some with Parkinson's disease and some without, about their nature exposure and well-being.…

This study looked at why Hispanic people with Parkinson's disease may experience more thinking and memory problems than non-Hispanic white patients. Researchers examined 40 people with Parkinson's to understand if heart-related health issues like diabetes, high blood pressure, an…

This study aimed to understand how to help people with Parkinson's disease better remember and retain motor skills they practice. Researchers compared two training methods—practicing a skill alone versus practicing while doing a second mental task—to see which leads to longer-las…

This study aimed to translate and test a short questionnaire designed to assess the risk of falling in people with Parkinson's disease. Researchers worked with 64 Turkish Parkinson's patients to see if the translated 5-question form was reliable and measured what it was supposed …

This study aimed to discover what makes someone more likely to develop Parkinson's disease. Researchers compared over 2,200 people, including those with Parkinson's, other brain conditions, and healthy individuals. They looked for links between genes, lifestyle, environment, and …

This study aimed to understand how deep brain stimulation (DBS) helps people with Parkinson's disease. Researchers measured blood flow in the brains of 15 patients with DBS implants while they performed simple hand movements and decision-making tasks. The goal was to see how turn…

This study tested a special smartwatch system designed to measure movement symptoms in people with Parkinson's disease. It involved 19 people, some with Parkinson's and some healthy, to see if the watch's measurements for things like walking, slowness, and involuntary movements m…

This study used advanced brain imaging (PET scans) to see how the frontal lobe works during thinking tasks. It compared healthy volunteers to people with conditions like schizophrenia and Parkinson's disease to understand brain function differences. The goal was to gather knowled…

This study aimed to understand how the brain changes in Parkinson's disease over time. Researchers used detailed brain scans (MRI) to compare 62 adults with definite Parkinson's, possible early signs, and healthy volunteers. Participants were followed for up to 9 years to see if …

This study aimed to understand how caregivers help people with Parkinson's disease who have difficulty swallowing eat their meals. Researchers filmed and interviewed 22 patient-caregiver pairs during mealtimes to learn about their strategies for balancing safety, nutrition, and e…

This study aimed to understand how gut bacteria are different in people with Inflammatory Bowel Disease (IBD) or Parkinson's Disease. Researchers compared stool and blood samples from 15 patients to see if specific bacteria could be linked to these conditions. The goal was to fin…

This study aimed to translate and test a short, 7-question survey designed to measure quality of life in people with Parkinson's disease. Researchers worked with 129 Turkish-speaking participants who have Parkinson's to see if the translated survey was reliable and measured what …

This study aimed to understand how the brain controls movement by comparing eye movements in different patient groups. Researchers tracked eye movements in 14 participants with dystonia, essential tremor, Parkinson's disease, and healthy volunteers. The goal was to see if differe…