Brain pump delivers dopamine directly to fight Parkinson's fluctuations
NCT ID NCT04332276
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tested a new approach for people with advanced Parkinson's disease who have severe motor fluctuations despite optimized oral medication. A pump placed in the abdomen delivered a special form of dopamine (A-dopamine) directly into the brain's fluid spaces, aiming to provide steady symptom control. Only 12 participants were enrolled, and the study compared this brain pump to optimized oral treatment over two one-month periods.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
A-dopamine (dopamine stored in anaerobia, delivered into brain ventricles)
What this could lead to
If it works, this could offer a new way to control severe motor ups and downs in Parkinson's with fewer daily pills.
What could go wrong
This is a very early, small study (12 people) testing an invasive brain procedure. It may not prove safe or effective, and risks include infection or pump problems.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hopital Roger Salengro, CHU Lille
Lille, 59037, France