New brain scan reveals how DBS rewires Parkinson's patients' brains
NCT ID NCT04922411
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study used a special brain imaging technique called HD-DOT to see how deep brain stimulation (DBS) changes brain network activity in 49 people with Parkinson's disease. Researchers compared scans with DBS turned on and off, while participants did motor and cognitive tests. The goal is to understand why DBS helps movement but can also cause mood or thinking side effects, which could lead to better DBS tuning and new treatment targets.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
deep brain stimulation (DBS) device
What this could lead to
If successful, this could help doctors fine-tune DBS settings more efficiently and identify new brain targets for less invasive treatments.
What could go wrong
This is a small, early-stage observational study (49 participants) using a new imaging technique, so results may not apply broadly or lead directly to clinical changes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University School of Medicine
St Louis, Missouri, 63110, United States