Could a pill cut falls in Parkinson's? new trial investigates

NCT ID NCT05258071

Completed Symptom relief Sponsor: Integrative Research Laboratories AB Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests whether a drug called pirepemat can reduce how often people with Parkinson's disease fall. Participants take the drug or a placebo for 84 days and record falls in a diary. The study includes people aged 55–85 who have had at least two falls in the past month. If it works, pirepemat could offer a new way to manage a common and dangerous symptom of Parkinson's.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pirepemat (also called IRL752)
What this could lead to: If successful, pirepemat could become a new treatment to reduce falls in people with Parkinson's disease, improving safety and quality of life.
What could go wrong: This is an early-phase trial with only 104 participants. The drug may not reduce falls more than a placebo, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

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Locations

CHU Charles Nicolle

Rouen, France
CHU Toulouse - Hôpital Purpan

Toulouse, France
Centrum Medyczne HCP SP Z OO

Poznan, Poland
Centrum Medyczne NeuroProtect

Warsaw, Poland
Charite Universitatsmedizin Berlin - Klinik fuer neurologie mit experimenteller neurologie

Berlin, Germany
Clinica Universitaria de Navarra

Pamplona, Spain
Diamond Clinic sp. z o.o.

Krakow, Poland
ETYKA Osrodek Badan Klinicznych

Olsztyn, Poland
Hopital de la Timone

Marseille, France
Hospital Clinic Barcelona

Barcelona, Spain
Hospital General Universitario de Elche

Elche, Spain
Hospital Infanta Sofia

Madrid, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario del Henares

Madrid, Spain
Hospital de Sant Pau

Barcelona, Spain
Hôpital Laennec - Centre d'investigation clinique de Neurologie

Nantes, France
Hôpital Neurologique Pierre Wertheimer

Bron, France
Institute of Neuroscience and Physiology

Gothenburg, Sweden
Instytut Zdrowia

Oświęcim, Poland
Karolinska Universitetssjukhuset - Neurologiska kliniken

Stockholm, Sweden
Kliniken Kreis Muehldorf a. Inn

Mühldorf, Germany
Klinische Forschung Hamburg GmbH

Hamburg, Germany
Klinische Forschung Schwerin GmbH

Schwerin, Germany
Krakowska Akademia Neurologii Sp. z o.o.

Krakow, Poland
Neuro-Care Clinic

Siemianowice Śląskie, Poland
Philipps-Universitaet Marburg

Marburg, Germany
Pratia MCM Krakow

Krakow, Poland
Praxis Dr.med. Christian Oehlwein Facharzt für Neurologie und Psychiatrie

Gera, Germany
RCMed

Sochaczew, Poland
RKU - Universitäts- und Rehabilitationskliniken Ulm Klinik für Neurologie

Ulm, Germany
Radboud Universitair Medisch Centrum (Radboudumc)

Nijmegen, Netherlands
Silmedic sp. z o.o

Katowice, Poland
Singua Sp. z o.o.

Warsaw, Poland
Skane University Hospital - Division of Neurology

Lund, Sweden
Universitaetsklinikum Leipzig - Klinik und Poliklinik fuer Neurologie

Leipzig, Germany
Universitysklinikum Münster - Klinik für neuroligie

Münster, Germany
Universitätsmedizin Göttingen - Klinik für Neurologie

Göttingen, Germany

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