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New drug targets stubborn tremors in Parkinson's

NCT ID NCT05642442

Completed Symptom relief Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called suvecaltamide for people with Parkinson's disease who still have moderate to severe tremor despite taking other medications. Over 17 weeks, 169 participants received either the drug or a placebo, with doses adjusted for best effect. The goal was to see if the drug could reduce tremor and improve daily activities like eating and dressing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
suvecaltamide
What this could lead to
If it works, this could lead to a new option for controlling stubborn tremor in Parkinson's disease that standard medications don't fully manage.
What could go wrong
This is an early Phase 2 trial with only 169 people, so results may not apply broadly. The drug may not prove more effective than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

movement disorder Parkinson disease Tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE TREMOR

Contacts and locations

Locations

  • Albany Medical College

    Albany, New York, 12208, United States

  • Central Texas Neurology Consultants

    Round Rock, Texas, 78681, United States

  • Centrum Medyczne Plejady

    Krakow, 30-363, Poland

  • Clinical Neuroscience Solutions, Inc.

    Jacksonville, Florida, 32256, United States

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

  • Curiositas-ad-sanum Beratungs-und Studien GmbH

    Haag in Oberbayern, 83527, Germany

  • Dent Neurologic Institute

    Amherst, New York, 14226, United States

  • Deutsche Klinik fur Diagnostik Helios Klinik Wiesbaden

    Hessen, 65191, Germany

  • ETG Neuroscience Sp. z o.o.

    Warsaw, 02-777, Poland

  • EverGreenHealth Neuroscience Institute

    Kirkland, Washington, 98034, United States

  • Gabinety Lekarskie Rivermed Sp. z o.o.

    Poznan, 61-441, Poland

  • Hawaii Pacific Health

    Honolulu, Hawaii, 96817, United States

  • Hospital Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Cruces

    Barakaldo, 48903, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Keck School of Medicine of University of Southern California (USC)

    Los Angeles, California, 90033, United States

  • Maxxmed Centrum Zdrowia i Urody w Lublinie

    Lublin, 20-080, Poland

  • Movement Disorders Center of Arizona

    Scottsdale, Arizona, 85258, United States

  • NeuroTrials Research Inc.

    Atlanta, Georgia, 30328, United States

  • Neurologia Slaska Centrum Medyczne

    Katowice, 40-689, Poland

  • Neurology of Central Florida Research Center LLC

    Altamonte Springs, Florida, 32714, United States

  • Niepubliczny Zaklad Opieki Zdrowotnej Neuromed M.i M. Nastaj Spólka Partnerska

    Lublin, 20-064, Poland

  • Northwestern Medical Group, Department of Neurology

    Chicago, Illinois, 60611, United States

  • Parkinson's Disease and Movement Disorder Center of Boca Raton

    Boca Raton, Florida, 33486, United States

  • Pharmakologisches Studienzentrum Chemnitz GmbH

    Chemnitz, 091111, Germany

  • South Shore Neurologic Associates PC

    Patchogue, New York, 11772, United States

  • The Nene and Jamie Koch Comprehensive Movement Disorders Center

    Albuquerque, New Mexico, 87106, United States

  • USF Parkinson's Disease and Movement Disorders Center

    Tampa, Florida, 33613, United States

  • University of Cincinnati Gardner Neuroscience Institute (UCGNI)

    Cincinnati, Ohio, 45219, United States

  • University of Colorado Hospital Anschutz Outpatient Pavilion

    Aurora, Colorado, 80045, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Kentucky, College of Medicine, Department of Neurology

    Lexington, Kentucky, 40536, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Velocity Clinical Research Germany GmbH, Location Wiesbaden

    Wiesbaden, 65189, Germany

  • Zentrum f. klinische Forschung Dr. I. Schöll

    Bad Homburg, 61350, Germany

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