New brain surgery technique for Parkinson's could be just as effective without keeping patients awake

NCT ID NCT04884412

Completed Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new way to place deep brain stimulation electrodes in people with Parkinson's disease. Instead of the usual method that requires patients to be awake for testing, the new approach uses MRI scans and a computer model to guide the surgery under general anesthesia. The trial involved 128 adults with advanced Parkinson's and compared motor improvement one year after surgery between the two methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deep brain stimulation surgery with a new MRI-based targeting method (PARKEO_2) under general anesthesia, without micro-electrode recordings
What this could lead to: If successful, this could make deep brain stimulation surgery more comfortable and consistent for Parkinson's patients by avoiding awake testing and reducing variability between centers.
What could go wrong: This is a completed trial with 128 participants, but the new method may not be as effective as the standard procedure, and results may not apply to all patients or centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PARKINSON DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

CHU Amiens

Amiens, France
CHU Marseille

Marseille, 13005, France
CHU de Bordeaux

Bordeaux, France
CHU de Nice

Nice, France
CHU de Rouen

Rouen, France
CHU de Strasbourg

Strasbourg, France
CHU de Toulouse

Toulouse, France
Hospices Civils de Lyon

Lyon, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.