Could common diabetes pills help Parkinson's and dementia?
NCT ID NCT06263673
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested whether two diabetes medications, sitagliptin and dapagliflozin, are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 participants took either a drug or a placebo daily for a short time. The goal was to see if these drugs could help control symptoms, not cure the diseases.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sitagliptin and dapagliflozin (diabetes medications)
What this could lead to
If successful, these common diabetes drugs could offer a new, well-tolerated option to help manage symptoms of Parkinson's disease and Lewy body dementia.
What could go wrong
This is a very small, early-phase trial with only 18 participants, so results may not apply to everyone. The drugs are not expected to cure these conditions, only possibly ease symptoms.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States