Parkinson's gene study links sleep problems to worse symptoms

NCT ID NCT04553185

Completed Knowledge-focused Sponsor: University of Exeter Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 733 people with Parkinson's disease to see if certain genetic variations in the AQP4 gene are linked to worse motor, cognitive, and sleep symptoms. Participants provided blood samples, wore sleep monitors, and completed online tests. The goal is to better understand how genes and sleep problems relate to Parkinson's progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify genetic markers that predict worse symptoms in Parkinson's disease, potentially guiding personalized care.
What could go wrong: This is an observational study, not a treatment trial. It only looks for associations, so it cannot prove cause and effect or lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

East Kent University Hospitals NHS Foundation Trust

Ashford, United Kingdom
Lewisham and Greenwich NHS Foundation Trust

London, United Kingdom
Prince Phillip Hospital

Llanelli, United Kingdom
University of Exeter

Exeter, SE16 7RJ, United Kingdom

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