Brain scans reveal clues about Parkinson's and serotonin

NCT ID NCT05916625

Completed Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study examined how a specific serotonin receptor (5-HT4) is expressed in the brains of people with mild to moderate Parkinson's disease compared to healthy older adults. Researchers used PET scans and a special tracer to measure receptor levels, alongside cognitive and motor tests. The goal was to better understand how changes in this receptor relate to both movement and non-movement symptoms. No treatment was given; it was purely an observational imaging study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help researchers better understand the role of serotonin receptors in Parkinson's disease, potentially pointing toward new targets for symptom management.
What could go wrong: This is an early exploratory study with only 40 participants, so results may not apply to all Parkinson's patients. It does not test any treatment, so no direct benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

CERMEP

Bron, 69500, France
Hôpital des Charpennes Centre de Recherche Clinique "Vieillissement-Cerveau-Fragilité"

Lyon, France

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