Could a common diabetes drug ease Parkinson's symptoms?
NCT ID NCT05781711
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested whether metformin, a widely used diabetes medication, could improve symptoms in people with Parkinson's disease. Sixty participants who were already taking levodopa received either metformin or a placebo. Researchers measured changes in movement and daily function using a standard rating scale, and also looked at blood markers like brain-derived neurotrophic factor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metformin
- What this could lead to
- If it works, metformin could become an add-on treatment to help control Parkinson's symptoms better.
- What could go wrong
- This is a small, early-phase trial with only 60 participants. Metformin is not a cure and may not show significant benefit over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PARKINSON DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Faculty of Medicine, Menoufia University
Tanta, Shebeen El-Kom, 32511, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood-flow cuffs may mimic exercise to ease Parkinson's symptoms
- Shake or sync: two therapies put to the test for Parkinson's mobility
- Wearable sensors aim to catch neurodegenerative decline in real time
- Can deep brain stimulation rewire faulty movement circuits? a surgery-time study aims to find out.
- The eyes as a window to the brain: can a simple scan monitor MS, Alzheimer's, and Parkinson's?
- Could a simple bowel rinse ease Parkinson's constipation and movement problems?