New brain scan could end misdiagnosis of Parkinson's and tremor

NCT ID NCT04265209

Completed Diagnosis Sponsor: GE Healthcare Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new PET scan tracer, [18F] LBT-999, to see if it can distinguish Parkinson's disease from essential tremor as well as the current standard SPECT scan. Researchers compared the two imaging methods in 152 patients. If the PET scan works equally well, it could offer a more precise and potentially faster diagnosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [18F] LBT-999 (a radioactive tracer for PET imaging)
What this could lead to: If successful, this could provide a more accurate and accessible way to diagnose Parkinson's disease versus essential tremor, helping patients get the right treatment sooner.
What could go wrong: This is a completed Phase 3 study, but the new PET tracer may not prove as effective as the standard SPECT method. Also, PET scanners are less widely available than SPECT, limiting real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential tremor Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL TREMOR PARKINSON DISEASE

Contacts and locations

Locations

CHRU Hôpital Bretonneau

Tours, 37044, France
CHU Bordeaux

Bordeaux, 33076, France
CHU La Pitié Salpêtrière

Paris, 75013, France
CHU La Timone

Marseille, 13005, France
CLCC Georges-François Leclerc C.G.F.L

Dijon, 21000, France
Centre Eugène Marquis / CHU Pontchaillou

Rennes, 35000, France
Centre Hospitalier Universitaire de Nîmes

Nîmes, 30029, France
Centre Jean PERRIN / Hôpital Gabriel Montpied (CHU)

Clermont-Ferrand, 63000, France
Hospices Civils de Lyon

Lyon, 69500, France
Hôpital Avicenne

Bobigny, 93000, France
Hôpital Brabois / Hôpital Central (CHRU Nancy)

Nancy, France
Hôpital Henri Mondor

Créteil, 94010, France
Hôpital Laennec (CHU Nantes)

Nantes, 44093, France
Hôpital Pierre Paul Riquet - Purpan (CHU)

Toulouse, 3100, France
Hôpital Roger Salengro (CHRU de Lille)

Lille, 59037, France
Institut de cancérologie Strasbourg Europe

Strasbourg, 67033, France

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