Free drug access for Parkinson's patients with specific gene mutation

NCT ID NCT07522606

NO_LONGER_AVAILABLE Disease control Sponsor: Bial R&D Investments, S.A. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This program offers continued free access to the experimental drug BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and have already completed the ACTIVATE study. Participants take one 60mg pill daily. The goal is to provide ongoing treatment while more data is collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BIA 28-6156 (a drug taken orally once daily)
What this could lead to: If it works, this could provide ongoing symptom control for people with a specific genetic form of Parkinson's disease.
What could go wrong: This is a small compassionate-use program, not a formal trial, so results may not apply broadly. The drug's long-term benefits and risks are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

central nervous system disorder GBA1-related Parkinson disease, susceptibility movement disorder neurodegenerative disease Parkinson disease parkinsonian disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

A.O.U. San Giovanni di Dio Ruggi d'Aragona Centro Parkinson- Piano Rialzato Corpo QT

Salerno, 84125, Italy
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Hospital Ruber Internacional

Madrid, 28034, Spain
Hospital Senhora da Oliveira de Guimaraes

Guimarães, 4835-044, Portugal
Hospital Universitaio de La Princesa

Madrid, 28006, Spain
Hospital Universitari Germans Trias i Pujol

Badalona, 08916, Spain
Hospital Universitario Cruces

Barakaldo, 48903, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital Vall D´Hebron

Barcelona, 08035, Spain
Hospital de la Santa Creu I Sant Pau

Barcelona, 08025, Spain
IRCCS Istituto Delle Scienze Neurologiche DI

Bologna, Italy
IRCSS San Raffaele Pisana

Roma, 163, Italy
Inland Northwest Research

Spokane, Washington, 99202, United States
Intermountain Healthcare

Salt Lake City, Utah, 84107, United States
King's College London - David Goldberg Centre

London, United Kingdom
MUSC

Charleston, South Carolina, 29425, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
NHS Tayside-Ninewells Hospital and Medical School

Dundee, United Kingdom
Northwestern University

Chicago, Illinois, 60611, United States
Ospedale Antonio Perrino

Brindisi, 72100, Italy
Park Nicollet Struther's Parkinson's Center (Struthers Parkinsons Center at HealthPartners)

Saint Paul, Minnesota, 55427, United States
Parkinson's Center and Movement Disorders of Boca Raton

Boca Raton, Florida, 33486, United States
Spedali Civilia di Brescia

Brescia, 25123, Italy
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital

Newcastle upon Tyne, United Kingdom
Universita degli Studi della Campania Luigi Vanvitelli - Clinica Neurologia I

Naples, 80138, Italy
Universita degli Studi di Padova - Azienda Ospedaliera di Padova - Clinica Neurologica

Padova, 35128, Italy
University Hospitals Plymouth NHS Trust

Plymouth, United Kingdom
University of Colorado

Aurora, Colorado, 80045, United States
University of Kansas Medical Center

Kansas City, Kansas, 66103, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Miami, Dept. of Neurology

Miami, Florida, 33136, United States
University of Washington

Seattle, Washington, 98195, United States
Vanderbilt Medical Center

Nashville, Tennessee, 37232, United States

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