Sound waves vs. Parkinson's: new trial tests Non-Invasive brain procedure

NCT ID NCT06584383

Ongoing Disease control Sponsor: InSightec Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a procedure called focused ultrasound (Exablate) that uses sound waves to target a small area in the brain involved in Parkinson's disease. It involves 67 people with early-stage Parkinson's who will either receive the ultrasound treatment or continue with standard medication. The goal is to see if the ultrasound can safely improve movement symptoms better than medication alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exablate MR-guided focused ultrasound (MRgFUS) subthalamotomy
What this could lead to: If successful, this could offer a non-invasive procedure to control motor symptoms in early Parkinson's, potentially delaying the need for stronger medications.
What could go wrong: This is a small, early-stage trial (67 people) testing a procedure that may not work for everyone. Risks include side effects from brain targeting, and the study does not aim to cure Parkinson's.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

Clinica Universidad de Navarra

Pamplona, 31008, Spain
HM CINAC- Hospital Universitario HM Puerta del Sur

Móstoles, 28938, Spain
Pontificia Universidad Catolica de Chile

Santiago, Chile
Universitätsklinikum Schleswig-Holstein, Campus Kiel (UKSH)

Kiel, 24105, Germany

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