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Sleep disorder may hold key to predicting Parkinson's before symptoms start

NCT ID NCT07729748

Ongoing Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This study investigates whether a combination of brain MRI scans, sleep recordings, and cognitive tests can track early brain changes in people with idiopathic REM sleep behavior disorder (iRBD), a condition that often precedes Parkinson's disease. Researchers will follow 50 people with iRBD and 50 healthy volunteers for three years, collecting data annually. The goal is to build a model that predicts which individuals are most likely to develop Parkinson's, potentially enabling earlier diagnosis and future preventive treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a way to identify people at high risk of developing Parkinson's disease years before motor symptoms appear, enabling earlier intervention.
What could go wrong
This is an observational study, not a treatment trial. It may not produce a reliable prediction model, and findings may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Nerve Degeneration neurodegenerative disease Parkinson disease REM sleep behavior disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC REM SLEEP BEHAVIOR DISORDER NEURODEGENERATION PARKINSON DISEASE PRODROMAL PARKINSON DISEASE

Contacts and locations

Locations

  • San Raffaele Hospital - Sleep Disorders Center, Department of Neurology, Turro

    Milan, Milano, 20127, Italy

  • San Raffaele Neurology Unit - Neuroimaging Research Unit

    Milan, Milano, 20132, Italy

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