Scientists probe brain activity during surgery to unlock Parkinson's cognitive mysteries

NCT ID NCT04715984

Recruiting now Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study aims to learn more about the brain activity behind cognitive impairment in Parkinson's disease. Researchers will record brain signals from 75 people during deep brain stimulation surgery while they perform a gambling task. The goal is to understand how certain brain areas work together and how stimulation affects decision-making.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help researchers understand why some people with Parkinson's develop thinking and memory problems, potentially pointing toward future treatments.
What could go wrong: This is an early observational study, not a treatment trial. It only involves 75 people and measures brain signals during surgery, so results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37212, United States

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