Gene therapy trial hopes to ease Parkinson's symptoms
NCT ID NCT06285643
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This Phase 2 study tests whether a single dose of AAV2-GDNF gene therapy, delivered directly into the brain, can improve motor function in adults with moderate Parkinson's disease. About 127 participants will receive either the gene therapy or a sham surgery. The main goal is to see if the treatment increases 'good on time' without troublesome side effects over 18 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AAV2-GDNF gene therapy
- What this could lead to
- If successful, this could lead to a new gene therapy that helps control Parkinson's symptoms and reduces the need for daily medications.
- What could go wrong
- This is an early Phase 2 trial with only 127 participants, so results may not apply to everyone. The sham surgery control group helps test safety, but there are risks from the surgical procedure and the gene therapy itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CenExel Rocky Mountain Clinical Research (Neurology)
RECRUITINGEnglewood, Colorado, 80113, United States
Contact Phone: •••-•••-••••
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Charité - Universitätsmedizin Berlin (Surgical)
ACTIVE_NOT_RECRUITINGBerlin, Germany
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Cleveland Clinic Lou Ruvo (Neurology)
RECRUITINGLas Vegas, Nevada, 89106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Copernicus Podmiot Leczniczy, Szpital św. Wojciecha (Neurology)
RECRUITINGGdansk, Poland
Contact Email: •••••@•••••
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Duke Neurosurgery (Surgical)
ACTIVE_NOT_RECRUITINGDurham, North Carolina, 27705, United States
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Duke University (Neurology)
RECRUITINGDurham, North Carolina, 27710, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University (Surgical)
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30322, United States
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EvergreenHealth Research Department (Neurology)
RECRUITINGKirkland, Washington, 98034, United States
Contact Email: •••••@•••••
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Georgetown University (Neurology)
RECRUITINGWashington D.C., District of Columbia, 20057, United States
Contact Email: •••••@•••••
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Houston Methodist (Neurology)
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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Houston Methodist (Surgical)
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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Loma Linda University (Neurology)
RECRUITINGLoma Linda, California, 92354, United States
Contact Email: •••••@•••••
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Loma Linda University (Surgical)
ACTIVE_NOT_RECRUITINGLoma Linda, California, 92354, United States
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Massachusetts General Hospital (Neurology)
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Email: •••••@•••••
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Massachusetts General Hospital (Surgical)
ACTIVE_NOT_RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic
NOT_YET_RECRUITINGPhoenix, Arizona, 85054, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mazowiecki Szpital Bródnowski (Neurology)
RECRUITINGWarsaw, Poland
Contact Email: •••••@•••••
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Mazowiecki Szpital Bródnowski (Surgical)
ACTIVE_NOT_RECRUITINGWarsaw, Poland
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Michigan State University (Neurology)
RECRUITINGEast Lansing, Michigan, 48824, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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North Bristol NHS Trust - Southmead Hospital (Neurology)
RECRUITINGBristol, United Kingdom
Contact Email: •••••@•••••
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Ohio State University (Surgical)
ACTIVE_NOT_RECRUITINGColumbus, Ohio, 43210, United States
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Orlando Health Neuroscience Institute
RECRUITINGOrlando, Florida, 32806, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Parkinson's Disease Treatment Center of Southwest Florida (Neurology)
RECRUITINGPort Charlotte, Florida, 33980, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Parkinson's Disease and Movement Disorders Center of Boca Raton (Neurology)
RECRUITINGBoca Raton, Florida, 33486, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Philipps-Universität Marburg (Neurology)
RECRUITINGMarburg, Germany
Contact Email: •••••@•••••
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Quest Research Institute (Neurology)
RECRUITINGFarmington Hills, Michigan, 48334, United States
Contact Email: •••••@•••••
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Rush University Medical Center (Neurology)
RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-••••
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Samodzielny Publiczny Szpital Kliniczny im. Prof. W. Orłowskiego CMKP (Neurology)
RECRUITINGWarsaw, Poland
Contact Email: •••••@•••••
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Specjalistyczna Praktyka Lekarska Prof. Grzegorz Opala (Neurology)
RECRUITINGKatowice, Poland
Contact Email: •••••@•••••
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Texas Movement Disorder Specialists
NOT_YET_RECRUITINGGeorgetown, Texas, 78628, United States
Contact Email: •••••@•••••
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UCI Alpha Clinic (Neurology)
RECRUITINGIrvine, California, 92697, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital of Wales (Surgical)
ACTIVE_NOT_RECRUITINGCardiff, United Kingdom
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University of California San Francisco (Neurology)
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
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University of Florida
NOT_YET_RECRUITINGGainesville, Florida, 32608, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Medical Center (Neurology)
RECRUITINGKansas City, Kansas, 66103, United States
Contact Email: •••••@•••••
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University of Miami
NOT_YET_RECRUITINGMiami, Florida, 33125, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of North Carolina (Neurology)
RECRUITINGChapel Hill, North Carolina, 27514, United States
Contact Email: •••••@•••••
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University of Pennsylvania (Neurology)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of San Francisco (Surgical)
ACTIVE_NOT_RECRUITINGSan Francisco, California, 94143, United States
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University of Utah
NOT_YET_RECRUITINGSalt Lake City, Utah, 84132, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Wisconsin (Neurology)
RECRUITINGMadison, Wisconsin, 53705, United States
Contact Email: •••••@•••••
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Universitätsklinikum Tübingen (Neurology)
RECRUITINGTübingen, Germany
Contact Email: •••••@•••••
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Universitätsklinikum Tübingen (Surgical)
ACTIVE_NOT_RECRUITINGTübingen, Germany
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Universitätsklinikum Würzburg (Neurology)
RECRUITINGWürzburg, Germany
Contact Email: •••••@•••••
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Vanderbilt University (Neurology)
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Shake or sync: two therapies put to the test for Parkinson's mobility
- Wearable sensors aim to catch neurodegenerative decline in real time
- Can deep brain stimulation rewire faulty movement circuits? a surgery-time study aims to find out.
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