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New study aims to perfect dosing of Parkinson's rescue drug

NCT ID NCT07145190

Recruiting now Symptom relief Sponsor: Bial - Portela C S.A. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study is testing SL-APO (Kynmobi), a fast-acting film placed under the tongue, to treat OFF episodes in people with Parkinson's disease. OFF episodes are times when Parkinson's symptoms return between medication doses. The study will enroll 90 adults and observe how doctors adjust the dose in real-world settings, aiming to find the most effective and safe dose for each person. The goal is to improve patient satisfaction and treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SL-APO (apomorphine sublingual film, brand name Kynmobi)
What this could lead to
If successful, this study could help doctors find the most effective and tolerable dose of SL-APO for quickly relieving Parkinson's OFF episodes, improving patient satisfaction and daily function.
What could go wrong
This is an early real-world study with only 90 participants, not a large controlled trial. Results may not apply to all patients, and side effects like nausea or dizziness are possible.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Alexianer St. Joseph Berlin-Weißensee GmbH

    SUSPENDED

    Berlin, 13088, Germany

  • Charité - Universitätsmedizin Berlin - Sektion für Bewegungsstörungen und Neuromodulation

    RECRUITING

    Berlin, 10117, Germany

  • Die Nerven Docs

    RECRUITING

    Siegen, 57072, Germany

  • Katholisches Klinikum Bochum gGmbH, Universitätsklinikum St.Josef-Hospital, Klinik für Neurologie

    NOT_YET_RECRUITING

    Bochum, 44791, Germany

  • Klinik am Tharandter Wald

    RECRUITING

    Hetzdorf, 09633, Germany

  • Klinik für Neurologie und Neurologische Frührehabilitation

    RECRUITING

    Osnabrück, 49076, Germany

  • Neurologie am Funkerberg

    RECRUITING

    Wusterhausen, 15711, Germany

  • Neurologische Klinik Sorpesee

    RECRUITING

    Sundern, 59846, Germany

  • Praxis für Neurologie

    RECRUITING

    Berlin, 15366, Germany

  • Praxis für Neurologie und Geriatrie

    RECRUITING

    Ulm, 89073, Germany

  • Praxis für Neurologie und Psychiatrie

    RECRUITING

    Fulda, 36037, Germany

    Contact Email: •••••@•••••

  • UNIVERSITÄTSKLINIKUM FREIBURG - Neurozentrum Klinik für Neurologie und Neurophysiologie im Neurozentrum

    RECRUITING

    Freiburg im Breisgau, D-79106, Germany

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