Gut check: could your intestines hold clues to Parkinson's and MS?

NCT ID NCT06329453

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and their activity, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal how gut immune cells influence brain diseases, potentially pointing toward new treatment targets.
What could go wrong: This is an early observational study, not a treatment trial. It may not lead directly to therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis Parkinson disease REM sleep behavior disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS PARKINSON DISEASE REM SLEEP BEHAVIOR DISORDER

Contacts and locations

Locations

Yale MS Clinic
RECRUITING

North Haven, Connecticut, 06473, United States

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