New pill aims to smooth out Parkinson's motor swings

NCT ID NCT07432958

Recruiting now Symptom relief Sponsor: Appello Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This study tests an experimental drug called AP-472 in people with Parkinson's disease who have motor fluctuations—times when their usual levodopa medication stops working well. About 150 participants will take either a low dose, a high dose, or a placebo pill for 8 weeks, added to their regular levodopa. The goal is to see if AP-472 can increase the time they feel good and moving well (ON time) without causing unwanted side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AP-472
What this could lead to: If it works, this could lead to a new add-on treatment that helps Parkinson's patients spend more time in the 'ON' state with fewer movement problems.
What could go wrong: This is an early Phase 2 trial with only 150 people, so results may not apply to everyone. The drug may not reduce OFF time more than a placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dyskinesias Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

Asheville Neurology Specialists, P.A. (Site #229)
RECRUITING

Asheville, North Carolina, 28806, United States
Augusta University Medical Center (Site #212)
NOT_YET_RECRUITING

Augusta, Georgia, 30912-0020, United States
Beth Israel Deaconess Medical Center (Site #211)
NOT_YET_RECRUITING

Boston, Massachusetts, 02215-5400, United States
Central Texas Neurology Consultants (Site #203)
RECRUITING

Round Rock, Texas, 78681-3578, United States
Cleveland Clinic (Site #223)
NOT_YET_RECRUITING

Cleveland, Ohio, 44195-0001, United States
Collaborative Neuroscience Network - Los Alamitos- CenExel - PPDS (Site #217)
RECRUITING

Los Alamitos, California, 90720-3108, United States
Duke Neurological Disorders Clinic (Site #210)
NOT_YET_RECRUITING

Durham, North Carolina, 27705, United States
EvergreenHealth (Site #219)
RECRUITING

Kirkland, Washington, 98034-3013, United States
Horizon Clinical Research: Gill Neuroscience - Houston (Site #232)
NOT_YET_RECRUITING

Cypress, Texas, 77429, United States
Joan and Sanford I. Weill Department of Medicine (Site #224)
RECRUITING

New York, New York, 10021, United States
Josephson Wallack Munshower Neurology PC (Site #231)
NOT_YET_RECRUITING

Indianapolis, Indiana, 46256, United States
Keck Medicine of USC - USC Healthcare Center 2 (Site #221)
NOT_YET_RECRUITING

Los Angeles, California, 90033-5310, United States
Kentucky Neuroscience Institute (Site #213)
RECRUITING

Lexington, Kentucky, 40536-0001, United States
Mount Sinai School of Medicine (Site #209)
RECRUITING

New York, New York, 10029-6501, United States
Neurology One (Site #205)
RECRUITING

Orlando, Florida, 32825, United States
Parkinson's Disease & Movement Disorders Center of Boca Raton (Site #227)
RECRUITING

Boca Raton, Florida, 33486, United States
Parkinson's Research Centers of America (Site #218)
RECRUITING

Palo Alto, California, 94301, United States
Profound Research LLC (Site #222)
RECRUITING

Carlsbad, California, 92011, United States
Quest Research Institute - Alcanza - PPDS (Site #201)
RECRUITING

Farmington Hills, Michigan, 48334-2973, United States
Rocky Mountain Clinical Research - CenExel - PPDS (Site #215)
RECRUITING

Englewood, Colorado, 80113-2776, United States
The Ohio State University Wexner Medical Center (site #207)
RECRUITING

Columbus, Ohio, 43210, United States
The University of Kansas (KU) (Site #216)
RECRUITING

Kansas City, Kansas, 66160, United States
UM-UHealth at Boca Raton (Site #226)
RECRUITING

Boca Raton, Florida, 33486, United States
USF Parkinson's Disease and Movement Disorders Center (Site #206)
RECRUITING

Tampa, Florida, 33613-4808, United States
University of Arkansas for Medical Sciences (Site #208)
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205-5551, United States
University of Miami (Site #220)
RECRUITING

Miami, Florida, 33136-1051, United States
University of Michigan Health System (UMHS) (Site #202)
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of New Mexico Health Sciences Center (Site #225)
RECRUITING

Albuquerque, New Mexico, 87106, United States
Vanderbilt University Medical Center (Site #204)
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Velocity Clinical Research - Hallandale Beach (Site #228)
RECRUITING

Hallandale, Florida, 33009, United States

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