New pill aims to smooth out Parkinson's motor swings

NCT ID NCT07432958

Recruiting now Symptom relief Sponsor: Appello Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called AP-472 in people with Parkinson's disease who have motor fluctuations—times when their usual levodopa medication stops working well. About 150 participants will take either a low dose, a high dose, or a placebo pill for 8 weeks, added to their regular levodopa. The goal is to see if AP-472 can increase the time they feel good and moving well (ON time) without causing unwanted side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AP-472

What this could lead to

If it works, this could lead to a new add-on treatment that helps Parkinson's patients spend more time in the 'ON' state with fewer movement problems.

What could go wrong

This is an early Phase 2 trial with only 150 people, so results may not apply to everyone. The drug may not reduce OFF time more than a placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Dyskinesias Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Augusta University Medical Center
NOT_YET_RECRUITING

Augusta, Georgia, 30912-0020, United States
Beth Israel Deaconess Medical Center
NOT_YET_RECRUITING

Boston, Massachusetts, 02215-5400, United States
Central Texas Neurology Consultants
RECRUITING

Round Rock, Texas, 78681-3578, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195-0001, United States
Collaborative Neuroscience Network - Los Alamitos- CenExel - PPDS
NOT_YET_RECRUITING

Los Alamitos, California, 90720-3108, United States
Duke Neurological Disorders Clinic
NOT_YET_RECRUITING

Durham, North Carolina, 27705, United States
EvergreenHealth
NOT_YET_RECRUITING

Kirkland, Washington, 98034-3013, United States
Joan and Sanford I. Weill Department of Medicine
NOT_YET_RECRUITING

New York, New York, 10065, United States
Keck Medicine of USC - USC Healthcare Center 2
NOT_YET_RECRUITING

Los Angeles, California, 90033-5310, United States
Kentucky Neuroscience Institute
NOT_YET_RECRUITING

Lexington, Kentucky, 40536-0001, United States
Mount Sinai School of Medicine
NOT_YET_RECRUITING

New York, New York, 10029-6501, United States
Movement Disorder Clinic of Oklahoma PLLC
NOT_YET_RECRUITING

Tulsa, Oklahoma, 74136-7027, United States
Neurology One
NOT_YET_RECRUITING

Orlando, Florida, 32825, United States
North County Neurology Associates
NOT_YET_RECRUITING

Oceanside, California, 92056-4454, United States
Parkinson's Research Centers of America
NOT_YET_RECRUITING

Palo Alto, California, 94301, United States
Quest Research Institute - Alcanza - PPDS
RECRUITING

Farmington Hills, Michigan, 48334-2973, United States
Rocky Mountain Clinical Research - CenExel - PPDS
NOT_YET_RECRUITING

Englewood, Colorado, 80113-2776, United States
The Ohio State University Wexner Medical Center
NOT_YET_RECRUITING

Columbus, Ohio, 43202-4500, United States
The University of Kansas (KU)
NOT_YET_RECRUITING

Kansas City, Kansas, 66103-2078, United States
USF Parkinson's Disease and Movement Disorders Center
NOT_YET_RECRUITING

Tampa, Florida, 33613-4808, United States
University of Arkansas for Medical Sciences
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205-5551, United States
University of Miami
NOT_YET_RECRUITING

Miami, Florida, 33136-1051, United States
University of Michigan Health System (UMHS)
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of New Mexico Health Sciences Center
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87131-0001, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States