OSTEOPOROSIS

This study is testing whether a daily probiotic/prebiotic supplement can help slow bone loss in women aged 60 and older. Researchers will compare the supplement against a placebo in 220 women over 18 months to see if it improves bone density and strength. The study focuses on die…

This study is testing a new plan to help people safely stop a long-term osteoporosis drug called denosumab (Prolia). When this drug is stopped suddenly, bones can weaken quickly. Researchers want to see if giving a half-dose of the drug for a short time, along with a different bo…

This study aims to find the best schedule for two bone-strengthening drugs (romosozumab and denosumab) for postmenopausal women with severe osteoporosis. Researchers will compare a new alternating 6-month cycle over two years against the standard one-year-each schedule. The goal …

This study is testing whether simple blood tests can show if osteoporosis medications are working much faster than the standard bone density scan. It involves 40 postmenopausal women with osteoporosis who will receive one of two types of bone-strengthening drugs. Researchers will…

This study is testing a new support program for people with osteoporosis or who have broken a bone. The program helps patients manage their bone-strengthening medications and learn about nutrition and fall prevention. Researchers will follow 200 patients for two years to see if t…

This study is investigating whether a common Alzheimer's disease medication, donepezil, might also help improve bone health and reduce fracture risk in older adults. Researchers will measure changes in bone density and bone-related markers in the blood over 12 months in 45 partic…

This study is testing whether having surgeons directly refer osteoporosis patients to bone specialists before hip or knee replacement surgery leads to fewer complications. Researchers will compare this new referral pathway to the current standard of care where patients are told t…

This study is testing whether a medication already approved for treating osteoporosis (denosumab) can also help preserve muscle strength and function in frail older adults living in nursing homes or assisted living. The goal is to see if this drug can reduce the risk of dangerous…

This study aims to find the best way to educate people with osteoporosis to help them manage their condition. It will compare three approaches: standard information, a digital course, and in-person group sessions. Researchers will measure how these programs affect patients' knowl…

This study is testing a new care program called OPTIONS for older adults recovering from a broken hip or leg in a nursing facility. The program provides coordinated support for exercise, healthy eating, and bone-strengthening medication during rehab and after going home. Research…

This study aims to see if drinking dairy milk or plant-based beverages (pea or almond) after strength training helps improve bone health in postmenopausal women and men aged 50+. Over 12 months, 150 participants will do supervised strength training three times a week and drink th…

This study is testing if denosumab, a common osteoporosis medication, can also improve muscle strength and how the body processes sugar (insulin sensitivity) in postmenopausal women with type 2 diabetes. It will involve 40 participants who will receive either the real drug or a p…

This study tests whether connecting patients who recently broke a bone due to osteoporosis with a bone health specialist through a patient navigator helps prevent future fractures better than standard education. It involves over 2,600 adults aged 50+ who have had a fragility frac…

This study is testing whether using two different bone-strengthening medications together works better than either one alone for treating osteoporosis in postmenopausal women. It will involve 90 women who have not recently taken other osteoporosis drugs. Researchers will measure …

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study is testing a new artificial intelligence (AI) system designed to help doctors diagnose and determine the severity of two common age-related conditions: osteoporosis (weak bones) and osteoarthritis (joint wear-and-tear). The AI will analyze X-rays, CT scans, and MRIs fr…

This study is testing a new, portable ultrasound device called POROUS that measures bone density without using X-rays. Researchers want to see if it works as well as the current standard DXA scan, which is a large, stationary X-ray machine. They are enrolling 350 healthy men and …

This study is testing whether a new bone-strengthening procedure can prevent a second hip fracture in older women with osteoporosis who have just broken one hip. During surgery to repair the first broken hip, some participants will also receive the new treatment on their other, u…

This trial is testing whether two existing bone-strengthening drugs, denosumab or zoledronic acid, can prevent bone loss in older adults who have survived a serious illness requiring intensive care. It will involve 450 women aged 50+ and men aged 70+ who spent more than a day in …

This study is testing whether a virtual program led by a chiropractor is a practical way to help people after a spine fracture caused by osteoporosis. The program focuses on pain management, safe movement, exercise, and nutrition through weekly video sessions. The main goal is to…

This study is testing a smart wearable device called gaitQ, which is worn on the legs. It uses gentle vibrations to help people with long-term movement conditions like Parkinson's, stroke, and multiple sclerosis improve their walking, reduce freezing episodes, and potentially low…

This study is testing if adding a specific exercise program called Baduanjin to usual post-surgery care can help elderly patients with osteoporosis and herniated discs in their lower back. Researchers want to see if the exercises reduce pain, build strength, and improve quality o…

This study aims to check the accuracy and consistency of various laboratory tests and research procedures used to study chronic diseases like obesity, diabetes, and heart failure. It will enroll up to 100 adults, both healthy and with certain conditions, to perform tests multiple…

This study aims to see if a new scoring system helps doctors choose the best treatment for spinal fractures caused by osteoporosis. It will enroll 648 older adults with these fractures and compare recovery when doctors follow the score's recommendation versus when they don't. The…

This research aims to understand exactly how osteoporosis makes bones more likely to fracture by looking at microscopic damage. Researchers will analyze small bone samples from 52 adults undergoing hip replacement surgery, using powerful imaging and computer models. The goal is t…

This study aims to learn more about how blood stem cells work in older adults, especially those with common age-related genetic changes. Researchers will collect bone marrow and blood samples from 24 people aged 65+ who are having hip replacement surgery. They will compare the ac…

This study is testing a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5-18. It aims to see how well this method works for kids with various conditions that can weaken bones, like osteoporosis or growth hormone deficiency. The goal …

This study aims to understand what helps or prevents doctors from using a practical guide for managing osteoporosis in frail elderly patients. Researchers will interview about 15 doctors in the Alsace region of France who have had access to the guide. The goal is to learn how to …

This study aims to understand how much older adults know about osteoporosis (bone weakening) and how well they understand health information. Researchers will survey 190 men aged 70+ and women aged 65+ using questionnaires. The goal is to identify factors that influence knowledge…