OSTEOPOROSIS

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This study aimed to see if romosozumab (Evenity) could improve bone density and muscle mass in postmenopausal women with osteoporosis undergoing lumbar spine surgery. Participants would have received monthly injections of romosozumab or weekly alendronate pills for 12 months. How…

This study tests whether taking teriparatide (a bone-building drug) for one month before lumbar fusion surgery helps surgeons place screws more securely in patients with osteoporosis. About 192 participants will be randomly assigned to receive either the drug or no pretreatment. …

This study looks at whether taking teriparatide (Forteo) for 24 months can improve bone structure in 100 men and women with osteoporosis. Researchers will use a special CT scan to see changes in bone thickness and microarchitecture at the wrist and shin. The goal is to understand…

This study looks at how teriparatide, a bone-building drug for severe osteoporosis, affects bone structure in postmenopausal women. Researchers will use a special scanner to see changes in bone thickness and tiny connecting rods at the wrist and ankle over 24 months. The goal is …

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study looks at 40 adults with osteoporosis who already completed a year of treatment with either Alendronate or Teriparatide. In this follow-up, participants will switch to the other drug for another year to see which works better for bone loss. The goal is to find a more pe…

This study tests whether a year of monthly injections of romosozumab, followed by an infusion of zoledronic acid, can improve bone density and prevent fractures in women aged 65 and older with osteoporosis who live in long-term care facilities. The goal is to find a treatment tha…

This study looks at how well the drug Prolia works for men with osteoporosis in mainland China. About 102 men aged 30 to 90 with weak bones will receive Prolia injections. The main goal is to see if bone density in the lower spine improves after 12 months of treatment.

This early-stage trial is testing a new stem cell treatment called HMM910 in 9 postmenopausal women with osteoporosis who are at high risk of breaking a bone. The stem cells are given through an IV drip. The main goal is to see if the treatment is safe and tolerable, not yet to p…

This study tests whether a new drug called SAL023 works like the approved osteoporosis medicine Evenity. It involves 118 healthy Chinese adults who get a single dose of either SAL023 or Evenity. The goal is to compare how the body processes the drug, its safety, and any immune re…

This early study tests a drug called romosozumab in 10 postmenopausal women who have both multiple myeloma and osteoporosis. The goal is to see if it safely improves bone formation and reduces bone breakdown caused by the cancer. Researchers will measure bone health markers and w…

This study looks at whether giving zoledronate infusions can prevent bone loss in postmenopausal women who have stopped taking denosumab for osteoporosis. About 200 women who took denosumab for at least two years will receive zoledronate at different times. The goal is to find th…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This study was designed to see if a special bone scanner (bone mineral analyser) could predict how well osteoporotic women would respond to a zoledronic acid infusion. The plan was to measure bone texture and density before and one year after treatment. However, the study was wit…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study tests a handheld device called the Osteoprobe that measures bone strength by pressing on the shinbone. Researchers want to see if it can identify women at risk for hip and wrist fractures better than standard bone density scans. About 190 women with recent fractures an…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This study tests whether a supervised resistance exercise program can reduce the risk of osteoporosis and osteoarthritis in women aged 50-70 who have gone through menopause. Participants will do leg and core exercises twice a week for 30-40 minutes. Researchers will measure chang…

This study compares three care models to prevent falls and fractures in older adults recovering from a broken bone in a skilled nursing facility. About 3,780 participants across 42 facilities will receive either medication reduction, bone health management, or both. The goal is t…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study looks at how bone contributes to citrate levels in urine, which may help explain why some people have low urine citrate. Researchers will study 25 adults with untreated osteoporosis, giving them potassium citrate and measuring changes in urine citrate and bone markers.…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study tests whether sending information letters to doctors and patients after a fracture can improve osteoporosis care. Over 4,200 older adults in Manitoba who had a hip, spine, arm, or wrist fracture are included. The goal is to see if these notifications increase bone dens…

This study looks at whether common osteoporosis medications also improve muscle health in adults aged 65 and older. Researchers will measure changes in muscle mass, strength, and walking speed over time. The goal is to better understand the link between bone and muscle health in …

This study was designed to test whether adding arm exercises to a standard osteoporosis medication could improve bone density in the wrist. It was planned for postmenopausal women at high fracture risk. However, the study was withdrawn before enrolling any participants, so no res…

This study aimed to see if a web-based fracture liaison service (e-FLS) could help more older adults start osteoporosis treatment after a fracture compared to standard in-person services. It planned to include men and women over 60 in France who had a low-trauma fracture. However…