OSTEOPOROSIS

This study looks at whether taking a bone-strengthening drug called teriparatide for one month before lumbar fusion surgery helps surgeons place screws more securely in patients with osteoporosis. The trial involves 192 participants and measures screw tightness during surgery, as…

This study compares two osteoporosis medications—romosozumab followed by denosumab versus denosumab alone—in 40 adults with a spinal cord injury that happened less than six months ago. The goal is to see which approach better maintains bone density around the knee over two years.…

This study looks at how teriparatide, a bone-building drug, affects the inner structure of bones in 100 men and women with osteoporosis over 24 months. Researchers use a special 3D scanner to see changes in bone thickness and shape at the wrist and shin, beyond just bone density.…

This study looks at a way to help older adults get tested and treated for osteoporosis after they break a bone. Many people don't realize a fracture can be a sign of weak bones, and they miss out on care that could prevent more breaks. The researchers are testing a system that no…

This study looks at how teriparatide, a drug that builds new bone, changes bone structure in 60 postmenopausal women with severe osteoporosis over two years. Researchers want to see if the drug affects bone thickness differently at the wrist versus the ankle, which could help pre…

This early-phase study tests whether romosozumab, a drug that builds bone, is safe and effective for postmenopausal women who have both multiple myeloma and osteoporosis. The study involves 10 participants and measures changes in bone formation markers. It aims to find a new way …

This study tests whether giving older women (65+) in long-term care a monthly injection of romosozumab for one year, followed by an annual infusion of zoledronic acid, can improve bone density and prevent fractures. The goal is to find a more effective treatment sequence for oste…

This study tests whether switching osteoporosis patients from one drug to another after one year improves bone loss. It involves 40 adults aged 45 and older who already completed a related trial. Participants will take either Alendronate or Teriparatide for one year, then switch …

This early-stage study tests the safety of a new stem cell treatment called HMM910 for postmenopausal women with severe osteoporosis who are at high risk of breaking a bone. Nine women aged 45 to 85 will receive the injection and be monitored for side effects. The goal is to see …

This study looks at how well the drug Prolia works and how safe it is for Chinese men with osteoporosis. About 102 men aged 30 to 90 with low bone density or a history of fractures will receive Prolia injections. The main goal is to see if bone density in the lower spine improves…

This early-stage study tests whether a new drug called SAL023 works the same as the approved drug Evenity for osteoporosis. It involves 118 healthy Chinese adults aged 18-45. The main goal is to compare how the body processes each drug and to check for side effects. This is not a…

This study was designed to see if a web-based fracture liaison service (e-FLS) helps more people over 60 start osteoporosis treatment within a year after a low-trauma fracture, compared to standard fracture liaison services. The study was withdrawn before enrolling any participan…

This study looks at whether different types of resistance exercise (like lifting weights) can help prevent osteoporosis (weak bones) and osteoarthritis (joint disease) in women aged 50 to 70 who have gone through menopause. Researchers will measure changes in bone density, muscle…

This study looks at three different care models to help older adults (65+) avoid falls and broken bones after they've already had a fracture. About 3,780 people in skilled nursing facilities will take part. The goal is to see which approach works best: reducing risky medications,…

This study aimed to see if a special bone assessment technique could predict how well bone health improves after treatment with zoledronic acid in women with osteoporosis. It planned to measure bone texture and density before and after the infusion. However, the study was withdra…

This study looks at whether a new, minimally invasive tool can measure bone tissue properties to better identify women at risk for hip and wrist fractures. Researchers will compare these measurements with standard bone density tests in 190 women, including those with recent fract…

This study looks at whether common osteoporosis medications also improve muscle health in adults aged 65 and older who have both osteoporosis and low muscle mass (sarcopenia). Researchers will measure changes in muscle mass, strength, walking speed, and bone density over time. Th…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong use medical services more wisely and feel more in control of their health. About 1,728 women will either receive the nurse coaching or general health advice. The goal is to see if …

This study looks at how bone health influences citrate levels in urine, which is important for preventing kidney stones. Researchers will measure bone density and turnover in 25 people with untreated osteoporosis before and after they receive standard osteoporosis medications. Th…