New drug combo may protect bones after spinal cord injury
NCT ID NCT05101018
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adults aged 18-55 who have had a spinal cord injury for less than 6 months. Researchers will measure bone mineral density using X-ray scans to see which approach works best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Romosozumab (Evenity) and Denosumab (Prolia)
- What this could lead to
- If successful, this could point toward a better treatment sequence to prevent severe bone loss and fractures after spinal cord injury.
- What could go wrong
- This is a small early-phase trial with only 40 participants, so results may not apply to everyone. Romosozumab carries heart risks, and the study excludes people with heart disease or stroke history.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
James J. Peters VA Medical Center
The Bronx, New York, 10468, United States
-
Kessler Institute for Rehabilitation
West Orange, New Jersey, 07052, United States
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