Can a $2 freeze spray take the ouch out of joint shots?
NCT ID NCT06651788
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether spraying a numbing coolant (ethyl chloride) on the skin before a corticosteroid injection reduces pain and anxiety. 300 adults receiving their first joint or soft-tissue injection will be randomly assigned to get either the freeze spray or a placebo cold saline spray. Researchers will measure pain scores and patient satisfaction to see if the spray makes a real difference.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ethyl chloride (freeze spray)
What this could lead to
If it works, this could provide a simple, low-cost way to make common joint injections less painful and anxiety-provoking.
What could go wrong
This is a small, early-stage trial testing a temporary numbing spray. The effect may be small or no better than a placebo spray.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••