University Of Chicago

This study tests whether a weekly injection of semaglutide (Wegovy), a drug used for weight loss and diabetes, can help people with trichotillomania (hair-pulling disorder). Ten adults aged 18-75 with daily hair pulling will receive the drug for several weeks. Researchers will me…

This study tests whether pharmacy technicians can help people with HIV get long-acting injectable medication more easily at community clinics in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to improve access to modern HIV tr…

This study tests whether giving young people (ages 18-35) living with HIV a monthly payment of $500 for 18 months helps them stay in care and keep the virus under control. About 304 participants who have faced financial hardship will be randomly assigned to receive either the cas…

This study tests whether adding fianlimab to the immunotherapy cemiplimab works better than cemiplimab alone at preventing cancer return in people with HPV-positive head and neck cancer who have signs of leftover cancer after initial treatment. About 68 adults will receive either…

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study tests whether adding fianlimab to the standard cemiplimab plus chemotherapy can better shrink tumors in adults with advanced HPV-positive head and neck cancer. About 90 participants will receive either the two-drug or three-drug combination before radiation. The goal i…

This study tests the drug Enhertu in 43 people with newly diagnosed HER2-positive stomach, esophageal, or gastroesophageal junction cancer that has spread. Participants have a lower physical ability (ECOG 2) and will receive Enhertu by IV every 3 weeks. The main goal is to see ho…

This study looks at whether daily step counts can help monitor how well vulnerable patients with metastatic hormone-sensitive prostate cancer are doing on a combination of darolutamide and standard hormone therapy. About 80 adults who are frail or have other health issues will we…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study tests whether aripiprazole (Abilify) can reduce urges and behaviors in adults with trichotillomania (hair-pulling) or skin-picking disorder. One hundred participants will receive either the drug or a placebo for 6 weeks. Researchers will track symptom changes using sta…

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study tests whether valbenazine can safely reduce symptoms in adults with moderate-to-severe obsessive-compulsive disorder (OCD). About 30 participants will receive either the drug or a placebo in a crossover design, meaning everyone gets both over time. The main goal is to …

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests whether low-dose radiation can safely ease arthritis pain and swelling that some cancer patients get from immunotherapy. About 20 adults with cancer who developed joint inflammation from their treatment will receive six small radiation doses over 2-3 weeks. The m…

This study will test whether a continuous glucose monitor (CGM) worn for 14 days after childbirth can predict which women with a history of gestational diabetes are at risk for developing type 2 diabetes. Fifty participants will wear a blinded CGM device and then take a standard …

This study will collect blood samples, brain scans, and medical information from 270 people with penetrating brain injuries. The goal is to create a large research database that scientists can use to better understand these injuries and improve future treatments. Participants mus…

This study will compare patient satisfaction between telehealth (video or phone) and in-person follow-up visits after minimally invasive gynecologic surgery. About 100 women will be randomly assigned to one of the two follow-up methods. The goal is to see if virtual visits are as…

This study looks at how gut bacteria affect diarrhea and other stomach issues in people with HR+/HER2- breast cancer taking the drug abemaciclib. In the first part, researchers will collect stool samples to track bacteria changes. In the second part, a small group will try eating…

This study will test whether using 3D-printed models of a patient's own anatomy helps transgender individuals better understand peritoneal vaginoplasty surgery. Twenty adults seeking vaginoplasty at the University of Chicago will receive personalized 3D models to aid in education…

This registry will follow 3,000 men with benign prostatic hyperplasia (BPH) who undergo Aquablation, a waterjet-based procedure to remove excess prostate tissue. Researchers will collect data from medical records to evaluate how well the procedure improves urinary symptoms and it…

This study will test whether taking apple cider vinegar every day for a short time changes the chemistry of urine in adults, both those with a history of calcium oxalate kidney stones and healthy volunteers. Researchers will measure levels of citrate, pH, calcium, and calcium oxa…

This study looks at whether certain bacteria in your stool can help predict if colon cancer will come back after surgery. Researchers will collect stool and blood samples from 107 adults before and after their surgery. They want to see if bacteria that break down collagen are lin…