University Of Chicago

This study tests whether adding fianlimab to the standard drug cemiplimab can better prevent cancer from returning in people with HPV-positive head and neck cancer who have tiny amounts of cancer still detectable after initial treatment. About 68 adults will receive either cemipl…

This study looks at whether adding a medication called cytisine to intensive counseling helps people with HIV in Kenya quit smoking and stop heavy drinking. About 300 participants will be followed to see if they can stay smoke-free and avoid heavy alcohol use. The goal is to impr…

This study tests whether adding fianlimab to standard cemiplimab and chemotherapy can better shrink advanced head and neck cancers in adults with HPV-positive disease. About 90 participants will receive either the two-drug or three-drug combination before radiation. The goal is t…

This study looks at how daily step counts change in 80 vulnerable adults with metastatic hormone-sensitive prostate cancer who are taking darolutamide plus standard hormone therapy. Researchers want to see if physical activity levels relate to treatment safety and quality of life…

This study tests whether pharmacy technicians can help more people with HIV receive long-acting injectable medication at community health centers in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to make it easier for patients…

This study tests whether lactulose, a type of sugar, can make immunotherapy more effective for people with advanced cancer. About 55 participants will take lactulose alongside their standard immunotherapy. Researchers will check if lactulose increases helpful gut bacteria and imp…

This early-phase study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are genetically modified to better recognize and attack cancer cells,…

This study tests the drug Enhertu in people with newly diagnosed HER2-positive advanced cancer of the esophagus, stomach, or gastroesophageal junction who have limited physical function (ECOG score of 2). The goal is to see how well the drug shrinks tumors and what side effects o…

This study tests whether giving young people living with HIV a guaranteed income of $500 per month for 18 months helps them stay in care and achieve viral suppression. About 304 participants aged 18-35 who have faced financial hardship will be randomly assigned to receive either …

This study looks at whether a continuous glucose monitor (CGM) can spot blood sugar issues in women who had gestational diabetes after they give birth. About 50 women will wear a CGM for a few days and then take a standard glucose drink test 4-12 weeks after delivery. The goal is…

This study looks at whether a trained peer mentor, along with text messages over 12 months, can help caregivers of people with dementia feel less lonely and more confident finding end-of-life resources. About 330 caregivers will take part. The goal is to improve caregiver well-be…

This study tests whether aripiprazole, a medication already used for other conditions, can reduce the urges and severity of hair-pulling (trichotillomania) and skin-picking (dermatillomania) in adults. About 100 participants will take either aripiprazole or a placebo for 6 weeks,…

This study tests whether a once-weekly injection of semaglutide (Wegovy) can reduce the urge to pull hair in people with trichotillomania. Ten adults aged 18-75 with daily hair-pulling will receive the drug for several weeks. Researchers will measure changes in hair-pulling sever…

This study tests if low-dose radiation can safely relieve joint pain and swelling caused by immunotherapy cancer treatment. About 20 adults with cancer who have developed arthritis from their immunotherapy will receive radiation to up to 3 affected joints. The main goal is to che…

This study looks at whether text message reminders can help adolescents and young adults (ages 15-39) with acute lymphoblastic leukemia (ALL) stick to their daily oral chemotherapy schedule during the maintenance phase. About 38 participants will either receive frequent text remi…

This study tests whether the drug valbenazine can safely reduce obsessive-compulsive disorder (OCD) symptoms in adults with moderate to severe OCD. Thirty participants will receive both valbenazine and a placebo at different times, without knowing which they are taking. The goal …

This study looks at whether follow-up visits by video or phone are as good as in-person clinic visits for women after minimally invasive gynecologic surgery. About 100 women will be randomly assigned to either a telehealth or in-person follow-up. The main goal is to see if patien…

This study looks at whether certain bacteria in the stool can help predict if colorectal cancer will come back after surgery. Researchers will collect stool and blood samples from 107 adults before and after their surgery. The goal is to see if bacteria or their byproducts play a…

This study creates a database to track how well Aquablation (a waterjet procedure) works for men with an enlarged prostate (BPH). Researchers will review medical records of 3000 patients who have had or will have the procedure. The goal is to understand long-term safety and effec…

This study looks at how the bacteria in your gut (microbiome) might influence diarrhea and other stomach issues caused by the breast cancer drug abemaciclib. It involves 20 adults with HR+/HER2- breast cancer. First, researchers will collect stool samples to study gut bacteria. T…

This study will test whether taking apple cider vinegar every day for a short time changes the chemistry of urine in adults. Researchers want to see if it can increase citrate (a natural stone blocker) and reduce substances that form kidney stones. The study includes 30 adults, s…

This study tests whether personalized 3D-printed models of a patient's own anatomy can help transgender individuals better understand peritoneal vaginoplasty surgery. Researchers will enroll 20 adults seeking gender-affirming vaginoplasty at the University of Chicago. The goal is…