University Of Chicago

This study is testing a targeted cancer drug called trastuzumab deruxtecan (Enhertu) in people newly diagnosed with advanced HER2-positive stomach or esophageal cancer who are too frail for standard combination chemotherapy. The main goal is to see how well the drug shrinks tumor…

This study aims to see if a medication called aripiprazole can help adults who struggle with compulsive hair pulling or skin picking. Over 6 weeks, 100 participants will take either the real medication or a placebo pill, and researchers will measure changes in their symptoms and …

This study is testing if taking lactulose, a type of sugar, can change the gut bacteria in a way that makes immunotherapy more effective for people with advanced cancer. It will involve about 55 adults with specific cancers who are already scheduled to receive immunotherapy. Rese…

This small, early-stage study is testing if a weekly injection of semaglutide (sold as Wegovy for weight loss) can help adults with trichotillomania, a disorder that causes strong urges to pull out one's own hair. Ten participants will receive the drug for eight weeks to see if i…

This study is testing if adding a new drug called fianlimab to a standard immunotherapy (cemiplimab) and chemotherapy works better for shrinking tumors in adults with advanced HPV-positive head and neck cancer. It will compare the two-drug combo to the single drug to see which le…

This study is for adults with HPV-positive head and neck cancer who have finished their main treatment but still have tiny traces of cancer in their blood. It will test if adding a new drug called fianlimab to an existing immunotherapy (cemiplimab) works better than the single dr…

This study is testing whether daily text message reminders can help teenagers and young adults with acute lymphoblastic leukemia (ALL) remember to take their oral chemotherapy pills during long-term maintenance treatment. Researchers will compare medication-taking habits between …

This early-phase study is testing a new personalized treatment for adults with advanced ovarian cancer and other solid tumors that have come back or stopped responding to standard therapies. Doctors will modify a patient's own immune cells in a lab to better recognize and attack …

This study is creating a large database to track the long-term results of a waterjet procedure for men with an enlarged prostate (BPH). It will follow 3,000 men who have the procedure as part of their regular care to see how well it relieves urinary symptoms and improves quality …

This study aims to find the best way to help people living with HIV in Kenya quit smoking and cut back on heavy drinking. It will test a combination of intensive counseling and a medication called cytisine. The goal is to improve long-term health outcomes for 300 participants who…

This study is testing if a small, wearable glucose monitor worn for two weeks after pregnancy can predict a woman's risk of developing diabetes. It aims to provide an easier alternative to the standard lab test, which many new mothers find hard to complete. The research involves …

This study tests whether connecting dementia caregivers with trained peer mentors and personalized community resource lists can improve their well-being. Over 330 caregivers will receive education, resource information, and ongoing text message support for 12 months. Researchers …

This early-stage study tests whether low-dose radiation can safely reduce arthritis pain caused by cancer immunotherapy drugs. The trial will enroll 20 patients who developed joint pain and swelling while receiving immunotherapy for cancer. Researchers will measure pain relief an…

This study is testing whether a medication called valbenazine can safely reduce the severity of obsessive-compulsive disorder (OCD) symptoms. It will involve 30 adults with moderate-to-severe OCD. Each participant will try both the study drug and a placebo for 6 weeks each to see…

This study aims to find out if patients are just as satisfied with telehealth follow-up visits as they are with traditional in-person visits after minimally invasive gynecologic surgery. Researchers will randomly assign 100 women to receive either virtual or in-person postoperati…

This study aims to understand if bacteria in a person's gut at the time of colon cancer surgery might cause the cancer to come back later. Researchers will collect stool, blood, and tissue samples from about 107 patients before and after their surgery to look for specific bacteri…

This study aims to see if taking apple cider vinegar daily for two weeks changes the chemistry of a person's urine. Researchers will enroll 30 adults, including some with a history of kidney stones and some without, to measure specific substances in their urine. The goal is to ga…

This study explores whether creating personalized 3D-printed models of a patient's anatomy can improve their understanding of a complex gender-affirming surgery called peritoneal vaginoplasty. Researchers at the University of Chicago will use these models to help explain the proc…

This study aims to understand if daily physical activity, measured by step count, is linked to how well older and vulnerable men with advanced prostate cancer respond to standard treatment. Researchers will follow 80 participants for 6 to 12 months to see if step counts relate to…