University Of Chicago

This study tests whether using a continuous glucose monitor (CGM) with the help of a Patient Navigator can improve diabetes management and quality of life for people with type 1 diabetes. The study includes 150 participants aged 14 to 64 who have had serious diabetes complication…

This study tested whether using a person's genetic information to adjust the dose of a chemotherapy drug (irinotecan) could help patients with advanced stomach or esophageal cancer. The goal was to see if this personalized approach could make surgery more successful by shrinking …

This study looks at whether multiple myeloma patients who have no signs of cancer after a stem cell transplant can safely stop their maintenance therapy. About 68 adults who have been on maintenance drugs for at least a year will be tested using advanced imaging and lab methods t…

This study is for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation, and whose cancer has worsened after standard treatments. The goal is to test the safety of combining two drugs, AVUTOMETINIB and cetuximab, and find the best dose. …

This study compares two drug combinations (KRd and VRd) in 250 people newly diagnosed with multiple myeloma. The goal is to see which combination better delays cancer progression. Participants will receive one of the two treatments, and researchers will track how long they live w…

This phase 2 study tests whether adding the immunotherapy drug pembrolizumab to the chemotherapy drug docetaxel can shrink tumors in people with advanced thyroid or salivary gland cancers that are not responding to standard treatments. About 46 adults with these rare, hard-to-tre…

This study tests a combination of four drugs (daratumumab, carfilzomib, lenalidomide, and dexamethasone) in 75 people newly diagnosed with multiple myeloma. The goal is to see how many achieve a very deep remission (stringent complete response) and have no detectable cancer cells…

This study tests adding a precise type of bone marrow radiation (IMTMI) to standard chemotherapy before a second donor stem cell transplant. It is for people with blood cancers like leukemia that have returned after a first transplant. The goal is to find the safest radiation dos…

This study tests whether virtual group visits can help people with type 2 diabetes and at least one heart-related condition (like high blood pressure or obesity) improve their blood sugar control. About 720 adults with high A1C levels will take part. The main goal is to see if th…

This study tests a telehealth program for adults hospitalized with COPD. After discharge, participants receive a virtual home visit with a pharmacist to learn correct inhaler use. The goal is to improve medication safety and reduce emergency visits and readmissions.

This study compares two treatments for body-focused repetitive behaviors like hair-pulling and skin-picking: a behavioral therapy called ComB and the medication memantine. Twenty-six adults will try memantine for 8 weeks, then switch to therapy for 8 weeks. Researchers want to se…

This study planned to see if taking Myfembree (a daily pill) after fibroid surgery could delay the return of symptoms like heavy bleeding and pelvic pain, compared to usual care. It was designed for premenopausal women with uterine fibroids. However, the study was withdrawn befor…

This study tests adding the drug inotuzumab ozogamicin (InO) to standard treatment for adults newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if this chemotherapy-free approach leads to faster and deeper remission, …

This study tests whether giving two drugs (taxotere and trastuzumab) before surgery can eliminate all signs of invasive cancer in Nigerian women with HER2-positive breast cancer. About 53 women with stage II or III breast cancer who have not had prior chemotherapy will receive th…

This study tests a new way of caring for Medicare patients who are at high risk of being hospitalized. Instead of seeing different doctors in the hospital and clinic, each patient gets one doctor who cares for them in both places. The goal is to improve patient satisfaction and l…

This study compares two ways to help heal a torn meniscus in the knee: a bone marrow venting procedure versus a platelet-rich plasma injection. About 146 participants aged 16 and older with certain types of meniscal tears will be followed after surgery to see which method leads t…

This study looks at whether taking oral antibiotics for 6 extra days after getting a penile implant can lower the chance of infection. About 800 men with erectile dysfunction who are getting a specific type of implant will take part. The goal is to see if the extra pills help pre…

This study tests whether the drug sirolimus can prevent long-term lung scarring (pulmonary fibrosis) in people hospitalized with severe COVID-19 pneumonia. About 60 adults who need extra oxygen will receive sirolimus to see if it reduces the chance of developing fibrosis. The goa…

This study tests whether adding experimental immune-boosting drugs (HB-201 and HB-202) to standard chemotherapy can shrink HPV16-positive throat tumors more effectively. The goal is to reduce the amount of radiation or chemotherapy needed afterward, potentially lowering side effe…

This study tests whether adding two extra drugs (carfilzomib and dexamethasone) to standard lenalidomide maintenance therapy after a stem-cell transplant can delay the return of multiple myeloma. About 180 adults who have already had a transplant and are in stable condition will …

This study looks at whether a supervised physical fitness program can help people with a high body mass index (40-44) lose weight so they can become active on the kidney transplant waiting list. Ten adults who are currently listed as inactive due to obesity will take part. The ma…

This study tests the safety of transplanting donor islet cells into people with difficult-to-control type 1 diabetes. The goal is to see if the cells can help stabilize blood sugar and reduce the need for insulin injections. Participants also receive anti-rejection drugs to prote…

This early-stage trial is for people with stage IV non-small cell lung cancer. It tests whether giving immunotherapy drugs (nivolumab and ipilimumab) together with precise, high-dose radiation (SBRT) is safe. Participants are split into two groups: one gets radiation first, then …

This study tests whether a blood test that tracks tumor DNA can help doctors decide when to add short bursts of chemotherapy to standard immunotherapy for people with head and neck cancer that has returned or spread. About 30 adults will receive the immunotherapy drug pembrolizum…

This early-phase study tests the safety of combining the experimental drug venetoclax with a 10-day course of decitabine in adults with high-risk acute myeloid leukemia (AML). The 26 participants have AML that is relapsed, resistant, or has certain genetic markers. The main goal …

This study tests whether giving the immunotherapy drug pembrolizumab for one year after standard treatment can delay cancer recurrence in 100 people with high-risk head and neck cancer. Participants receive either pembrolizumab or a placebo, and researchers track how long they li…

This study looks at whether combining mammograms and breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the scr…

This pilot study tests whether a guideline-based heart health program can prevent heart dysfunction in African American women who had preeclampsia. Twenty women will be followed for 3 months after giving birth to see if the program improves heart strain and blood markers. The goa…

This study looks at whether adding CPAP (a machine that helps you breathe during sleep) to a lifestyle program can improve blood sugar and blood pressure more than lifestyle changes alone. Researchers are studying 174 overweight or obese adults with prediabetes and sleep apnea. T…

This study tests whether listening to nature sounds during a breast core needle biopsy can lower pain and anxiety compared to standard supportive conversation. About 200 patients will be randomly assigned to one of the two groups. Researchers will measure stress levels using ques…

This study tests a 24-week physical activity program designed specifically for Black women with asthma. The goal is to see if the program improves asthma control and quality of life compared to standard asthma education. About 224 women will take part, and researchers will also c…

This study tests whether tolcapone, a drug currently used for Parkinson's disease, can safely reduce symptoms in adults with moderate to severe obsessive-compulsive disorder (OCD). About 49 participants will receive either tolcapone or a placebo to see if it improves OCD severity…

This study tests if shorter courses of radiation are safe for people with lymphoma that has returned or not responded to treatment. About 30 participants will receive different shortened radiation schedules to find the safest dose. The goal is to reduce treatment time while contr…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depression who were actively suicidal. Ho…

This study aimed to see if a single 60-minute session of inhaled nitrous oxide (laughing gas) could reduce pain in people with fibromyalgia. It planned to enroll adults aged 18-75 with moderate to severe pain. However, the study was withdrawn before any participants were enrolled…

This study planned to test whether nitrous oxide (laughing gas) could help people with major depression. It was withdrawn before any participants enrolled, so no results are available. The goal was to find the best dose and schedule for future research.

This study tests whether a voice-activated app called EngAGE can improve physical and social function in frail, homebound adults aged 60 and older with at least two chronic conditions. Participants use the app at home to guide exercises and social activities, and researchers comp…

This early-stage study tests whether adding the drug acetazolamide to standard chemotherapy (temozolomide) is safe for people with a specific type of aggressive brain cancer called glioblastoma. Ten adults with newly diagnosed, MGMT-methylated tumors will receive the combination.…

This study looks at whether changing from lying flat to sitting up improves oxygen levels in patients with respiratory failure who are on a breathing machine. Researchers will measure oxygen and carbon dioxide in the blood to see if position makes a difference. The study involves…

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study aimed to find out whether using smaller or larger stitches during robotic prostate surgery helps men regain bladder control sooner. It was designed for men with prostate cancer undergoing robotic prostate removal. However, the study was withdrawn before enrolling any p…

This study compares different outreach strategies to see which works best for enrolling African American patients into early-phase cancer treatment trials. About 134 patients and their doctors will take part, with some receiving special outreach and others standard care. The goal…

This study looks at whether certain brain wave patterns (EEG markers) can predict how well the drug fenfluramine works for people with Lennox-Gastaut Syndrome (LGS), a severe form of epilepsy. Researchers will track 20 children and adults aged 2 to 35 over 6 months to see if chan…

This study looks at how sleep apnea might cause prediabetes in overweight or obese adults. Researchers will measure stress hormones in the blood to understand the connection. The goal is to learn more about why people with sleep apnea are at higher risk for diabetes.

This study looks at whether people who have had general anesthesia many times (more than 20) are more likely to be aware and remember things during surgery. Researchers will survey and review medical records of 1,000 patients aged 7 and older. The goal is to help doctors improve …

This study follows 800 young adults who drink alcohol regularly to understand why some people develop drinking problems. Participants complete questionnaires about how they feel after drinking alcohol and using other common substances. Researchers then check in with them for at l…

This study explores how different parts of the brain work together to form memories. Researchers will use brain stimulation and EEG recordings in 44 adults to see which brain signals are important for remembering. The goal is to better understand memory, which could help develop …

This study tests body-worn sensors to measure how well people with spinocerebellar ataxia (a rare brain disorder) can move and keep their balance. About 600 adults with and without the condition will wear the sensors while doing simple coordination tests. The goal is to see if th…

This study looks at the genes of 1,200 adults to find out why some people get chronic sinusitis. Participants must have a recent CT scan showing either normal sinuses or sinus disease. The goal is to identify genetic variations linked to the condition, which may lead to better un…

This early-phase study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-protective protein called BDNF in people with multiple sclerosis, long-COVID, or acute leukemia (in remission) who also have obesity and memory or thinking problems. …

This study looks at whether a blood test can detect signs of cancer returning after surgery for colorectal or appendix cancer that has spread to the abdomen. Researchers will collect blood samples from 55 patients before and after surgery to measure special markers in the blood. …

This study follows 500 adults who were in the ICU with breathing failure—some had COVID-19, some did not. Researchers want to see if COVID-19 leads to different long-term mental and physical problems. The goal is to better understand and treat these lasting effects.

This study tests a home visiting program for low-income families with toddlers aged 13-16 months. The program teaches parents how talking, interacting, and responding more can help their child's language and brain development. Researchers will follow 206 families for years to see…

This study tests a new way to screen for substance use disorders in people with HIV using an online patient portal, instead of only during clinic visits. The goal is to make screening easier and more accessible, especially for those who may face barriers. About 900 adults with HI…

This study looks at people with end-stage kidney disease who need a special vein connection (called a brachiocephalic fistula) for dialysis. The goal is to understand why this vein often narrows over time, which can cause problems with dialysis. Researchers will use imaging and c…

This study was designed to see if when you eat changes natural body chemicals that control eating for pleasure and energy use. Researchers planned to track healthy adults' hunger, blood sugar, and insulin over 24 hours. However, the study was withdrawn before enrolling anyone, so…

This study looks at how a gentle, noninvasive brain stimulation method affects memory. Researchers will record brain activity from electrodes already placed inside the skull for medical reasons. The goal is to learn more about how the brain supports memory, which could one day le…

This study tracks 500 adults admitted to the intensive care unit to see how their microbiome (the collection of bacteria in the body) changes during critical illness. Researchers will look at whether these changes are linked to survival, length of hospital stay, and long-term rec…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, or healthy sinuses. Researchers want to see if certain bacteria cause inflammation that leads to long-term sinus problems. The goal is to gather basic knowledge that could…

This study looks at how the timing of meals impacts the body's ability to use energy (metabolism) and insulin sensitivity in overweight adults aged 30 to 75. Researchers will track 200 participants to see if eating at certain times of day affects risk for type 2 diabetes and hear…

This study looks at how a type of brain stimulation called TMS affects memory and seizure activity in people with mesial temporal lobe epilepsy. About 34 adults will have memory tests, brain scans, and EEG before and after TMS. The goal is to see if targeting a specific brain net…