University Of Chicago

This study aimed to see if taking Myfembree (a combination pill) daily after fibroid removal surgery could delay the return of fibroids and improve quality of life. It was designed for premenopausal women with uterine fibroids who had surgery. However, the trial was withdrawn bef…

This study tests a 24-week lifestyle physical activity program designed for Black women with asthma. Participants are randomly assigned to either the activity program (group sessions, activity tracking, and text support) or an asthma education control group. The goal is to see if…

This early-stage study tests whether adding a drug called acetazolamide to standard chemotherapy (temozolomide) is safe for people with a newly diagnosed, aggressive brain cancer (glioblastoma). Ten adults will take both drugs daily for 21-day cycles. The main goal is to find any…

This study tests the safety and effectiveness of combining the experimental drug AVUTOMETINIB (VS-6766) with cetuximab in people with advanced colorectal cancer that has a KRAS mutation. It is for those whose cancer worsened after prior treatments or who cannot tolerate them. The…

This study tests two experimental vaccines (HB-201 and HB-202) given with standard chemotherapy drugs (carboplatin and paclitaxel) to people with HPV16-positive oropharyngeal cancer. The goal is to see if this combination can shrink tumors enough to allow less intensive follow-up…

This study tests a combination of four drugs (daratumumab, carfilzomib, lenalidomide, and dexamethasone) as the first treatment for people newly diagnosed with multiple myeloma. The goal is to see how many patients achieve a very deep response, including no detectable cancer cell…

This study looks at whether people with multiple myeloma who have no signs of cancer after a stem cell transplant and at least one year of maintenance therapy can safely stop taking their medication. Researchers will use advanced imaging and lab tests to detect even tiny amounts …

This pilot trial tests whether using a patient's genetic profile to determine the dose of irinotecan (a chemotherapy drug) can improve outcomes for people with advanced stomach or esophageal cancer. The study combines chemotherapy before and after surgery, with the goal of increa…

This early-stage trial tests a precise type of radiation (IMTMI) given with chemotherapy before a second donor stem cell transplant for people with advanced blood cancers that have returned. The goal is to find the safest dose and see if it can reduce side effects and prevent the…

This phase 2 trial is testing whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy drug docetaxel can shrink or control advanced thyroid and salivary gland cancers that are not responding to standard treatments. About 46 participants will receiv…

This study tests whether a 6-month exercise and personalized diet plan can help patients with obesity (BMI 40-44) lose weight so they can become active on the kidney transplant waiting list. Ten adults who are currently listed as 'inactive' due to their weight will follow a fitne…

This early-stage trial is for people with stage IV non-small cell lung cancer. It tests whether giving targeted radiation before or at the same time as two immunotherapy drugs (nivolumab and ipilimumab) is safe. The goal is to find the best radiation dose for different tumor loca…

This study tests whether adding two more drugs (carfilzomib and dexamethasone) to the standard maintenance drug lenalidomide after a stem-cell transplant can keep multiple myeloma from coming back longer. About 180 adults who have already had a transplant and are in stable condit…

This phase 3 trial tests whether a newer three-drug combination (carfilzomib, lenalidomide, dexamethasone, or KRd) works better than the current standard (bortezomib, lenalidomide, dexamethasone, or VRd) for people newly diagnosed with multiple myeloma. About 250 participants wil…

This study compares two biologic techniques used during meniscal tear surgery: a bone marrow venting procedure (BMVP) that releases stem cells, and a platelet-rich plasma (PRP) injection from the patient's own blood. About 146 participants aged 16 and older with specific meniscal…

This early-phase study tests the safety of combining venetoclax with decitabine in 26 adults with high-risk acute myeloid leukemia (AML). Participants have hard-to-treat forms of the disease, such as relapsed or genetically complex AML. The goal is to find the best dose and under…

This study looks at whether taking oral antibiotics for 6 extra days after getting a penile implant can lower the chance of infection. Researchers are following 800 men for one year after surgery. The goal is to see if this simple step reduces the need for another surgery to remo…

This Phase 2 trial is testing a combination of two drugs—docetaxel (chemotherapy) and trastuzumab (a targeted therapy)—in 53 Nigerian women with HER2-positive breast cancer. The goal is to see how many women have no cancer left after treatment (called a complete response). The st…

This study tests whether a video call with a pharmacist shortly after hospital discharge can help COPD patients use their inhalers correctly and avoid return trips to the hospital. About 218 adults hospitalized for a COPD flare-up will take part. The goal is to see if this telehe…

This study tests a new way of caring for Medicare patients who are at high risk of being hospitalized. Instead of seeing different doctors in the hospital and clinic, each patient gets one doctor who cares for them in both places. The goal is to improve patient satisfaction and l…

This study tests whether the drug sirolimus can prevent lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. About 60 adults who need extra oxygen will receive sirolimus to see if it reduces the chance of long-term lung damage. The goal is to find a way…

This study tests if transplanting donor islet cells into the liver can safely help people with difficult-to-control type 1 diabetes achieve normal blood sugar levels without insulin. Up to 50 adults aged 18-58 who have had diabetes for at least 5 years and still struggle with blo…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This study looks at whether a blood test can detect if cancer comes back after surgery for colorectal or appendix cancer that spread to the abdomen. Researchers will collect blood samples from 55 patients before and after surgery to measure DNA changes. The goal is to see if this…

This study looks at whether combining mammograms with breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the sc…

This study tests whether a computer program that spots early signs of acute kidney injury can improve patient care. Hospitalized adults at risk are randomly assigned to get an early kidney specialist visit or standard care. The goal is to see if early specialist advice can preven…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This pilot study tests whether remote monitoring and guideline-directed therapy can prevent heart dysfunction in African American women who had preeclampsia. Twenty participants will use a tablet, blood pressure cuff, and scale at home for three months after delivery. The goal is…

This study compares two treatments for body-focused repetitive behaviors like hair-pulling (trichotillomania) and skin-picking disorder. 26 adults will first take memantine (a drug) for 8 weeks, then receive 8 weeks of behavioral therapy. Researchers want to see which approach re…

This study tests whether tolcapone, a drug used for Parkinson's disease, can reduce symptoms of obsessive-compulsive disorder (OCD) in adults. About 49 people with moderate to severe OCD will receive either tolcapone or a placebo. The main goal is to see if the drug safely lowers…

This study tests a voice-activated app called EngAGE that lets care partners send encouraging messages to frail, homebound older adults. The goal is to see if this simple technology can improve physical function (like standing up from a chair) and reduce loneliness. The study inv…

This study aimed to see if a one-hour session of inhaled nitrous oxide (laughing gas) could reduce pain in people with fibromyalgia. It was designed for adults aged 18-75 with moderate to severe pain. However, the study was withdrawn before any participants were enrolled, so no r…

This study aimed to see if nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. Participants would have received four weekly sessions of the gas or a placebo. However, the study was withdrawn before any …

This study tests whether listening to nature sounds (like birds or water) during a breast core biopsy can lower pain and anxiety. About 200 participants will be randomly assigned to either hear nature sounds or receive standard supportive conversation. The goal is to see if natur…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively sui…

This study tests whether a shorter course of radiation (over 2-3 weeks instead of the usual 5-6 weeks) is safe for people with Hodgkin or Non-Hodgkin lymphoma that has returned or not responded to treatment. About 30 participants will receive different radiation doses to find the…

This study looks at whether taking DHA (an omega-3 fatty acid) supplements during pregnancy can improve maternal health, reduce stress, and lead to better birth and brain development outcomes for babies. Researchers are giving 168 low-income African American women either DHA or a…

This study follows 96 people with end-stage kidney disease who need a brachiocephalic fistula for dialysis. Researchers collect data from exams, blood tests, and imaging to track changes in the vein over time. The goal is to learn what causes cephalic arch stenosis, a common narr…

This study looks at whether specific brain wave patterns on an EEG can predict how well the drug fenfluramine works for people with Lennox-Gastaut Syndrome (LGS), a severe form of epilepsy. Researchers will follow 20 children and adults aged 2 to 35 who are already taking fenflur…

This study looks at whether giving doctors a patient's genetic information can help them personalize chemotherapy doses and reduce serious side effects. About 860 adults with certain cancers (like breast, stomach, or head and neck) will be randomly assigned to have their doctors …

This study looks at different ways to reach out to African American patients and their doctors to see if it helps more of them join early phase cancer treatment trials. About 134 people will take part. The goal is to find better methods to make cancer research more inclusive.

This study looks at how sleep apnea might cause prediabetes to turn into diabetes. Researchers will use CPAP machines and niacin infusions in 300 overweight, prediabetic adults with sleep apnea to measure changes in blood chemicals. The goal is to understand the biological steps …

This study tests whether a home visiting program called Thirty Million Words can help low-income parents talk and interact more with their young children, boosting language development. About 206 families with children aged 13-16 months are taking part. Researchers measure change…

This study examines how young adults who regularly binge drink respond to alcohol, caffeine, and Benadryl. Researchers want to see if these responses can predict future drinking patterns. About 800 participants will complete lab sessions and be followed for at least two years.

This pilot study tests whether liraglutide (Saxenda), a weight-loss drug, can raise levels of a brain-protective protein called BDNF in 30 people with multiple sclerosis, long-COVID, or leukemia who are overweight and have memory or concentration problems. Participants will injec…

This study tests a new program to make it easier for people living with HIV to get screened for substance use disorders. The program uses online patient portals and in-clinic tools to find those who need help and connect them to treatment. Researchers will track how many people g…

This study was designed to test whether using smaller or larger stitches during robotic prostate surgery helps men regain bladder control faster. It planned to enroll men with prostate cancer undergoing robotic prostate removal. However, the trial was withdrawn before any partici…

This study uses brain recordings and gentle magnetic stimulation to see how memory works. Twelve adults will have their brain activity measured while performing memory tasks. The goal is to understand the brain signals behind memory, which could help develop future treatments for…

This study uses small body-worn sensors to measure movement during simple coordination tests in people with spinocerebellar ataxia, a condition that affects balance and walking. Researchers aim to see if these sensors can accurately track disease severity and progression. The stu…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, and healthy individuals. By analyzing tissue samples from 285 participants, researchers hope to identify which bacteria are linked to long-term inflammation. The goal is t…

This study looks at the genes of 1,200 adults to find out why some people get chronic sinusitis. Participants must have a CT scan showing either normal sinuses or sinus disease. The goal is to identify genetic variations linked to the condition, which could lead to better underst…

This study uses brain stimulation and EEG recordings to understand how different brain areas work together to form memories. Researchers will test 44 adults to see if stimulating certain brain regions changes memory performance. The goal is to map the brain's memory network, whic…

This study aimed to understand how the timing of meals changes daily patterns of natural chemicals in the body that influence eating for pleasure and energy use. It planned to enroll healthy adults without sleep or metabolic disorders. However, the study was withdrawn before any …

This study looks at whether moving from lying flat to sitting upright improves oxygen levels in patients with respiratory failure who are on breathing machines. Researchers will measure oxygen and carbon dioxide levels in the blood. The study involves 16 adults and aims to unders…

This study looks at whether people who have had general anesthesia many times (more than 20) are more likely to be aware and remember things during surgery compared to those who have had it fewer than 5 times. Researchers will survey and review medical records of 1000 patients ag…

This study follows 500 ICU patients to compare long-term mental and physical health between those with and without COVID-19. Researchers use surveys and tests to measure quality of life, thinking skills, and emotional well-being. The goal is to identify specific problems caused b…

This study follows 500 adults admitted to the intensive care unit to see how their gut bacteria (microbiome) change during critical illness. Researchers will track deaths and recovery up to one year later. The goal is to understand whether these bacterial shifts affect short- and…

This study tests whether a Patient Navigator can help 150 people with type 1 diabetes use their continuous glucose monitors more effectively. The goal is to reduce health disparities and improve outcomes. Participants will receive extra support while using their standard CGM devi…

This study looks at how the timing of meals changes the way your body uses energy, especially in overweight adults aged 30 to 75. Researchers will compare eating most calories early versus late in the day, and test how this affects insulin sensitivity and metabolism. The goal is …

This pilot study at the University of Chicago is testing whether a non-invasive brain stimulation technique called TMS can improve memory and reduce seizure-related brain activity in people with mesial temporal lobe epilepsy (MTLE). Thirty-four adults with drug-resistant MTLE wil…