Gene-Guided chemo aims to boost surgery success in stomach cancer
NCT ID NCT02366819
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot trial tests whether using a patient's genetic profile to determine the dose of irinotecan (a chemotherapy drug) can improve outcomes for people with advanced stomach or esophageal cancer. The study combines chemotherapy before and after surgery, with the goal of increasing the chance of a complete tumor removal. It involves 36 participants and is currently suspended.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Chemotherapy drugs (oxaliplatin, leucovorin calcium, irinotecan hydrochloride, fluorouracil) plus surgery
- What this could lead to
- If successful, this could show that tailoring chemo doses based on a patient's genes reduces side effects and improves the chance of successful surgery.
- What could go wrong
- This is a small pilot trial (36 people) that has been suspended, so results are uncertain. The approach may not work for all patients or may still cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ESOPHAGEAL ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kellogg Cancer Center - Evanston Hospital
Evanston, Illinois, 60201, United States
-
NorthShore University HealthSystem
Evanston, Illinois, 60201, United States
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can AI-Guided home training boost recovery from gastric cancer surgery?
- Can switching cancer therapy early extend life in stomach cancer?
- Can a new drug combo shrink Hard-to-Treat tumors?
- Can immunotherapy outperform chemo after stomach cancer surgery?
- Could a smartphone program supervised by AI boost recovery after stomach cancer surgery?
- Can a swallowed balloon unlock the genetic secrets of esophageal cancer?