New drug cocktail aims to shrink tough prostate tumors before surgery

NCT ID NCT05726292

First seen Apr 06, 2026 · Last updated May 14, 2026 · Updated 10 times

Summary

This study tests whether adding a drug called relacorilant to standard hormone therapy and enzalutamide can better shrink high-risk prostate cancer before surgery. About 90 men with advanced, localized prostate cancer that hasn't spread will take the combination for 24 weeks, then have their prostate removed to check for remaining cancer. The goal is to see if the new combo leads to fewer cancer cells left behind, potentially lowering the chance of the cancer coming back.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Chicago Comprehensive Cancer Center

    RECRUITING

    Chicago, Illinois, 60453, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

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