Surgical fix for heartburn? new trial tests hiatal closure
NCT ID NCT06280664
First seen Dec 30, 2025 · Last updated Jun 19, 2026 · Updated 24 times
Summary
This study tests whether surgically closing the hiatal opening can control gastroesophageal reflux disease (GERD) in people with early-stage disease. Researchers will enroll 40 adults aged 18-50 with a small hiatal defect and confirmed acid reflux. The main goal is to see if the procedure alone can stop GERD, measured by pH testing.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
surgical procedure (hiatal closure)
What this could lead to
If successful, this could offer a surgical option to control GERD without long-term medication for people with early-stage disease.
What could go wrong
This is a small, early-phase trial with only 40 participants. The procedure may not work for everyone, and surgery always carries risks like infection or complications.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.