Magic mushroom compound shows promise for Tough-to-Treat depression and BPD

NCT ID NCT05399498

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 23 times

Summary

This small study tested a single dose of psilocybin, the active ingredient in magic mushrooms, in 9 adults with both major depression and borderline personality disorder. Researchers measured changes in depression and BPD symptoms over time to see if the treatment was safe and helpful. The goal was to explore whether this approach could ease symptoms in people with these overlapping conditions.

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Contacts and locations

Locations

  • University of Chicago

    Chicago, Illinois, 60637, United States

Conditions

Explore the condition pages connected to this study.