BORDERLINE PERSONALITY DISORDER

This study tests a new 12-session couple therapy called Sage for people with borderline personality disorder (BPD) and their partners. It aims to reduce BPD symptoms, improve relationship conflict, and support partner mental health better than standard individual therapy. Up to 1…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This study tests whether a special brain training technique, called mindfulness-based neurofeedback, can help adults with borderline personality disorder (BPD) get more out of their regular talk therapy. Researchers will use real-time brain scans to help participants learn to con…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, such as depression, anxiety, or PTSD, and assign them to practi…

This study tests whether adding a case manager and family meetings to standard care helps people with borderline personality disorder. About 100 adults will be randomly assigned to the new program or usual care. The goal is to see if the approach is practical and improves daily f…

This study tests whether combining a nasal spray (oxytocin) with a 5-week self-compassion training program can reduce symptoms like self-criticism, shame, and emotional instability in people with borderline personality disorder (BPD). About 80 adults with BPD will receive either …

This study tests whether Eye Movement Desensitization and Reprocessing (EMDR), a therapy proven for PTSD, can help people with borderline personality disorder (BPD). Researchers will give 56 adults 14 weekly EMDR sessions and measure changes in emotional and behavioral symptoms. …

This study tests whether real-time brain training (amygdala neurofeedback) can help people with borderline personality disorder (BPD) feel less intense negative emotions. Participants will either receive real feedback from their own brain activity or a fake (sham) signal while vi…

This study looks at how well a 20-week therapy called Dialectical Behavior Therapy for Adolescents (DBT-A) works for teens aged 13-18 who self-harm or have suicidal behavior. Researchers will track self-harm episodes, suicide attempts, depression, and quality of life right after …

This small study at Yale is testing whether a single dose of MDMA (the drug in ecstasy) can improve social cognition—like reading emotions and feeling sociable—in adults with borderline personality disorder. Ten participants will take the drug and complete tasks and surveys. It's…

This study tests a new type of mental training for people with borderline personality disorder (BPD). The training teaches a skill called 'reappraisal-by-distancing' to help control emotions. Researchers will use brain scans to see if the training changes brain activity and will …

This study tests a 10-week therapy program called SINTYA for young adults aged 16-25 with borderline personality disorder (BPD). The program combines group and individual sessions to reduce impulsivity and related symptoms like emotional distress, self-harm, and suicide risk. Res…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce symptoms of borderline personality disorder (BPD). Up to 30 adults with BPD will receive either real or sham TMS over several weeks. Researchers will trac…

This study tests whether group schema therapy, which uses self-recorded videos as part of treatment, can help teens with borderline symptoms. 64 participants will be randomly assigned to either the therapy or usual care. The therapy includes 30 group sessions, 8 individual sessio…

This study tests a new idea: that Borderline Personality Disorder (BPD) may be a form of addiction to close relationships, similar to substance use disorders. Researchers will give a special questionnaire to 194 people—those with BPD, those with bipolar disorder, and healthy volu…

This study looks at how gender affects the way people with borderline personality disorder (BPD) see themselves and their relationships. Researchers will interview 15 people with BPD of different gender identities and use special tests to measure hidden thoughts. The goal is to b…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study looks at how often dissociative identity disorder (DID) occurs in adults who experienced childhood trauma and have borderline personality disorder, functional dissociative crises, or early psychosis. Researchers will use interviews and questionnaires with 350 participa…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study follows 688 adults with borderline personality disorder (BPD) for 5 years to see if feeling shame can predict suicide attempts. Researchers will also look for biological markers and protective treatments. No new drug or therapy is being tested—this is purely an observa…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…