Could ecstasy help people with borderline personality disorder connect better?

NCT ID NCT06683014

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small study at Yale is testing whether a single dose of MDMA (the drug in ecstasy) can improve social cognition—like reading emotions and feeling sociable—in adults with borderline personality disorder. Ten participants will take the drug and complete tasks and surveys. It's an early, open-label trial, so results are preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MDMA (3,4-methylenedioxymethamphetamine)
What this could lead to: If it works, this could point toward a new way to help people with borderline personality disorder feel more connected and read emotions better.
What could go wrong: This is a very small, early-phase trial with only 10 people and no placebo group. The results may not apply to everyone, and MDMA can have side effects like increased heart rate or anxiety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

borderline personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BORDERLINE PERSONALITY DISORDER

Contacts and locations

Locations

Connecticut Mental Health Center
RECRUITING

New Haven, Connecticut, 06519, United States

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