MDD
Clinical trials for MDD explained in plain language.
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Brain training with real-time fMRI shows promise for depression relief
Symptom relief CompletedThis study tested a new therapy that uses real-time brain scans to help people with major depression shift their attention away from negative thoughts. 71 adults participated, and the approach aimed to reduce depression severity by retraining brain patterns. The therapy is non-in…
Matched conditions: MDD
Phase: NA • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated May 17, 2026 05:32 UTC
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Zapping the brain to feel joy again: new study tests personalized TMS for anhedonia
Symptom relief CompletedThis study tested a noninvasive brain stimulation technique called accelerated intermittent theta burst stimulation (aiTBS) in 60 adults with anhedonic depression—a type of depression where people lose interest or pleasure in things. Participants were randomly assigned to receive…
Matched conditions: MDD
Phase: NA • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated May 15, 2026 11:57 UTC
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VR headset boosts depression therapy in small trial
Symptom relief CompletedThis study tested whether using an extended reality (XR) headset to do behavioral activation therapy could help people with major depressive disorder. 26 adults with depression tried either XR-based therapy or standard real-life therapy. The goal was to see if the XR approach was…
Matched conditions: MDD
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated May 14, 2026 12:03 UTC
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Generic depression patch tested against brand in small study
Knowledge-focused CompletedThis study tested a generic version of the selegiline skin patch (6 mg/24 hours) against the brand-name EMSAM in 12 healthy adults. The goal was to see if the generic patch delivers the same amount of medicine into the body and to check for skin irritation. This was a pilot study…
Matched conditions: MDD
Sponsor: Corium Innovations, Inc. • Aim: Knowledge-focused
Last updated May 17, 2026 05:36 UTC