Magic mushroom compound tested as One-Time depression fix for cancer patients

NCT ID NCT06319378

Recruiting now Symptom relief Sponsor: Section for Affective Disorders; Northern Stockholm Psychiatry Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single 25 mg dose of psilocybin can relieve major depression in 100 adults with cancer, compared to a very low 1 mg dose. Participants must be 20–80 years old, have had depression for at least a month after their cancer diagnosis, and stop other antidepressants before the trial. The main goal is to measure changes in depression scores 42 days after the dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If successful, this could point toward a new, fast-acting treatment for depression in people with cancer, potentially easing severe mood symptoms with just one dose.
What could go wrong: This is a Phase 2 trial with only 100 participants, so results are preliminary. Psilocybin can cause temporary anxiety, confusion, or nausea, and its long-term safety in this population is not yet known.

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Conditions

The condition(s) this trial relates to.

cancer endogenous depression major depressive disorder neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MDD

Contacts and locations

Locations

Norra Stockholms Psykiatri
RECRUITING

Stockholm, Stockholm County, Sweden
Psykiatriska Kliniken, Akademiska Sjukhuset
RECRUITING

Uppsala, Uppsala County, Sweden
region Västra Götaland
RECRUITING

Gothenburg, Göteborg, Sweden
Örebro sjukhus
RECRUITING

Örebro, Örebro County, Sweden

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