ANHEDONIA

This study is observing how esketamine nasal spray works for people with severe, treatment-resistant depression in real-world clinics. It aims to see who benefits most from the treatment and how it affects their daily life, work, and social functioning. Researchers will also look…

This study is testing a digital platform called Vira to help prevent suicide in high-risk teenagers. The app allows therapists to monitor patients' mood, sleep, and behavior patterns through their smartphones. Researchers will compare teens using the app alongside their usual the…

This study is testing if a brief treatment to improve mood and reward processing can make standard exposure therapy more effective for people with social anxiety and a specific fear of public speaking. All 94 participants will receive exposure therapy, but first, they will be ran…

This study is testing whether a smartphone app called Vira, combined with support from a health coach, can help teens with depression feel more enjoyment from daily activities. Researchers want to see if this approach can reduce feelings of depression and suicidal thoughts. Parti…

This study is testing whether a gentle, non-invasive brain stimulation technique (tDCS) can help people with bipolar depression who struggle to feel pleasure or motivation (anhedonia). Researchers will use brain scans to personalize the treatment and see if it changes specific br…

This study is testing whether a gentle, non-invasive brain stimulation technique can help improve mood and emotional regulation in young adults experiencing mild depressive symptoms. Researchers will compare real stimulation to a placebo-like sham treatment to see if it reduces d…

This study is testing if a medication called L-DOPA can help people with depression who also have high inflammation and a specific symptom called anhedonia, which is the inability to feel pleasure. Seventy adults with depression will take either L-DOPA or a placebo for eight week…

This study is testing a two-week smartphone app program designed to help people who struggle to feel pleasure (anhedonia) and experience high stress, anxiety, or depression. Participants are randomly assigned to use an app with daily audio exercises focused on gratitude, positive…

This study is testing a mobile app called TrueBlue that aims to monitor signs of depression and anxiety in pregnant women and new mothers. For 12 weeks, 125 participants in the UK will use the app weekly, reading or speaking while it records their face and voice to generate mood …

This study aims to understand if a specific type of non-invasive brain stimulation can help people with depression who struggle to feel pleasure or motivation. Researchers will test the stimulation on 72 adults with major depression and high anhedonia over five consecutive days. …