APATHY

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This study tested a 12-week diet and exercise program in 40 older adults with insulin resistance and apathy, a motivation disorder. Participants received all meals and supervised exercise. The goal was to see if the program improves insulin sensitivity and reduces apathy, and whe…

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia. Researchers monitored 14 participants' movements and behaviors in real-life situations. The goal was to see if technology could provide a more objective way to a…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study tested whether methylphenidate (a drug used for ADHD) changes how healthy adults make decisions, put in effort, and learn from rewards. 35 participants completed tasks while on the drug or a placebo. The goal was to understand motivation, not to treat any condition.

This completed study looked at how apathy (lack of motivation) influences different forms of fatigue in 57 older adults with mild cognitive disorders. Participants wore an activity tracker for a week and completed tests like a 6-minute walk and questionnaires. The goal was to com…

This early-stage study tested a new drug called IRL757 in 12 healthy volunteers aged 65 to 89. The goal was to see how the drug is processed in the body and check for any safety issues. No treatment for any disease was given; this is a first step to gather information for future …