CF Drug's hidden impact on gut and lung bugs revealed
NCT ID NCT05937815
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tracks 253 cystic fibrosis patients starting a new drug combination (elexacaftor/tezacaftor/ivacaftor). Researchers collect sputum, stool, and blood samples at the start, 6 months, and 1 year to see how the drug changes bacteria and inflammation in the lungs and gut. The goal is to understand the drug's full effects beyond just breathing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Elexacaftor/Tezacaftor/Ivacaftor
- What this could lead to
- If successful, this could reveal how the drug improves gut and lung health in cystic fibrosis, guiding better future treatments.
- What could go wrong
- This is an observational study, not a treatment trial. It cannot prove the drug works or is safe, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AP-HM CRCM pédiatrique
RECRUITINGMarseille, France
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AP-HP CRCM Robert debré
RECRUITINGParis, France
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AP-PH Hopital Cochin service de pédiatrie
RECRUITINGParis, France
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APHP Hopital Necker
RECRUITINGParis, France
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CHRU de Lille CRCM Pédiatrique
RECRUITINGLille, France
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CHU de Bordeaux - CRCM pédiatrique
RECRUITINGBordeaux, France
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CHU de Grenoble Alpes CRCM pédiatrique
RECRUITINGGrenoble, France
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CHU de Limoges CRCM Limousin
RECRUITINGLimoges, France
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CHU de Montpellier
RECRUITINGMontpellier, France
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CHU de Nancy
RECRUITINGNancy, France
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CHU de Nice
RECRUITINGNice, France
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CHU de Rouen
RECRUITINGRouen, France
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CHU de Toulouse
RECRUITINGToulouse, France
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Fondation Ildys, Roscoff Centre Hélio Marin - Clinique "Mucoviscidose"
RECRUITINGRoscoff, France
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Hospices Civils de Lyon Service de pédiatrie, allergologie et mucoviscidose
RECRUITINGLyon, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A smartphone tool may help cystic fibrosis patients survive the lung transplant waitlist
- Can a smartphone app reveal how CF treatments really work at home?
- Can a peer coach help young people take control of their chronic illness?
- Could a single antibiotic be enough for cystic fibrosis lung infections?
- Early use of powerful CF drugs may boost growth in young children
- Hands-On therapy may soothe cystic fibrosis pain without drugs