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Which oxygen device best prevents Re-Intubation in High-Risk ICU patients?

NCT ID NCT07133698

Completed Disease control Sponsor: Assiut University Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests three breathing support methods—high-flow nasal cannula, high-velocity nasal insufflation, and noninvasive ventilation—in ICU patients at high risk of breathing failure after being taken off a ventilator. The goal is to see which approach helps patients breathe on their own for at least 48 hours without needing the ventilator again. The study enrolls adults who have been on a ventilator for more than 24 hours and meet readiness criteria.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
High-flow nasal cannula, high-velocity nasal insufflation, noninvasive ventilation
What this could lead to
If one method works best, it could reduce the need for re-intubation and improve survival in ICU patients at high risk of breathing failure after a ventilator.
What could go wrong
This is a single-center trial with 105 participants, so results may not apply to all ICU patients. The devices may not significantly differ in effectiveness.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WEANING FROM MECHANICAL VENTILATION

Contacts and locations

Locations

  • Assiut University hospital

    Asyut, 71515, Egypt

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