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Which oxygen device best prevents Re-Intubation in High-Risk ICU patients?

NCT ID NCT07133698

Disease control Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests three breathing support methods—high-flow nasal cannula, high-velocity nasal insufflation, and noninvasive ventilation—in ICU patients at high risk of breathing failure after being taken off a ventilator. The goal is to see which approach helps patients breathe on their own for at least 48 hours without needing the ventilator again. The study enrolls adults who have been on a ventilator for more than 24 hours and meet readiness criteria.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-flow nasal cannula, high-velocity nasal insufflation, noninvasive ventilation
What this could lead to
If one method works best, it could reduce the need for re-intubation and improve survival in ICU patients at high risk of breathing failure after a ventilator.
What could go wrong
This is a single-center trial with 105 participants, so results may not apply to all ICU patients. The devices may not significantly differ in effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

105 people

The number who actually took part.

Started

Feb 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 years) intubated for \>24 hours due to acute respiratory failure, identified as high-risk for extubation failure AND fulfilling standard readiness-to-wean criteria (e.g., resolution of cause of intubation, adequate gas exchange \[P/F ≥150\], hemodynamic stability, spontaneous breathing trial \[SBT\] success) Exclusion Criteria: * Patients with central nervous system disorders unrelated to hypercapnic encephalopathy or hypoxemia. * Patients with post arrest encephalopathy. * Patient with previous tracheotomy. * Patients who received noninvasive ventilation without subsequent intubation. * Patients with end organ failure.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weaning from mechanical ventilation

Contacts and locations

Locations

  • Assiut University hospital

    Asyut, 71515, Egypt

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