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Can breathing exercises help ICU patients break free from the ventilator?

NCT ID NCT02855619

Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests three different inspiratory muscle training programs in intensive care patients who have failed a first attempt to breathe on their own. The training uses a threshold device to strengthen the diaphragm and other breathing muscles. Researchers compare the programs to see which one best improves inspiratory strength and endurance, aiming to shorten the weaning period and increase the chance of successful ventilator removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Inspiratory muscle training using a threshold-based device, performed in three different protocols
What this could lead to
If one program proves better, it could offer a standard way to strengthen breathing muscles and help ICU patients leave the ventilator faster.
What could go wrong
The trial is small and not blinded, so results may be influenced by expectations. Training may not improve weaning success for all patients, and some may not tolerate the sessions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Oct 2016

Finished

Mar 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient ventilated more than 18h in a controlled mode; * First single breathe trial of 2 hours failure; * Presence of sevrability criterias definied by the European consensus conference in 2007 an usually used: * diminution of the sedfative agents, * Patients with spontaneous beath in VAC mode or patient ventilated in a VSAI-PEP mode, * PaO2/FiO2 ≥150, * Absence d'inotropes ou de vasopresseurs à forte dose ou dose croissante (\<1mg/h), * SaO2 \> 90% with FiO2 ≤ 50%, * PEP ≤ 8cmH2O, * Corporal température between 36°C and 39°C, * Glasgow Score ≥ 8. Exclusion Criteria: * Age \< 18 years ; * medically unstable; * Poor vital pronostic at very short term; * Cardiac arrest with a poor neurological prognostic; * Neuromuscular disease ; * Pneumothorax non drained ; * Tracheostomy ; * Current pregnancy ; * Patients with guardianship or trusteeship.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weaning from mechanical ventilation

Contacts and locations

Locations

  • Réanimation Médicale

    Bordeaux, 33076, France

  • Réanimation Médicale

    Lyon, 69004, France

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